【摘要】：目的觀察急性缺血性腦卒中患者血清正五聚蛋白3(PTX3)水平變化,并分析其與患者神經(jīng)功能缺損和近期預(yù)后的關(guān)系。方法選取急性缺血性腦卒中患者100例為病例組,來院體檢的志愿者100例為對照組。分別于入院第1、7、14天檢測兩組血清PTX3,進(jìn)行美國國立衛(wèi)生院神經(jīng)功能缺損評分(NHISS評分)以評價神經(jīng)功能缺損情況。對病例組隨訪3個月,采用改良Rankin量表(mRS)評分評價近期預(yù)后,比較不同程度殘疾患者血清PTX3水平。分析血清PTX3水平與急性缺血性腦卒中患者NHISS評分、mRS評分的相關(guān)性。結(jié)果病例組入院第7天血清PTX3水平高于入院第1、14天,且病例組入院第1、7、14天血清PTX3水平均高于對照組(P均0.05)。病例組患者血清PTX3水平與NHISS評分呈正相關(guān)關(guān)系(r=1.483,P0.01);血清PTX3水平與mRS評分呈正相關(guān)關(guān)系(r=1.299,P0.01)。隨訪3個月,病例組殘疾30例(mRS評分≥2分,輕度12例、重度8例、中重度6例、重度4例)、非殘疾(mRS評分2分)70例,末次隨訪時殘疾亞組血清PTX3水平高于非殘疾亞組(P0.01)。入院第7天不同殘疾程度患者血清PTX3水平均高于入院第1、14天(P均0.05);入院第7天時重度殘疾者、中重度殘疾者與中度殘疾者血清PTX3水平高于輕度殘疾者(P均0.01);重度殘疾者入院第1、7、14天血清PTX3水平均高于輕度殘疾者(P均0.05)。結(jié)論急性缺血性腦卒中患者血清PTX3水平升高,且與NHISS評分、mRS評分均呈正相關(guān)關(guān)系;血清PTX3水平越高,急性缺血性腦卒中患者的神經(jīng)功能缺損程度越嚴(yán)重、近期預(yù)后越差。
[Abstract]:Objective to observe the changes of serum normal pentagglutinin 3 (PTX3) levels in patients with acute ischemic stroke, and to analyze the relationship between PTX3 levels and neurological deficit and short-term prognosis. Methods 100 patients with acute ischemic stroke were selected as case group and 100 volunteers as control group. Serum PTX3 was measured on the 1st day and 14th day after admission. The neurological deficit score (NHISS) of the National Institutes of Health (NIH) was used to evaluate the neurological impairment. The patients were followed up for 3 months to evaluate the short-term prognosis with modified Rankin scale (Mrs) and to compare the serum PTX3 levels in patients with different degrees of disability. To analyze the correlation between serum PTX3 level and NHISS score and Mrs score in patients with acute ischemic stroke. Results the serum PTX3 level on the 7th day after admission was higher than that on the 1st day of admission, and the serum PTX3 level of the case group was higher than that of the control group on the 1st day of admission (P 0.05). There was a positive correlation between serum PTX3 level and NHISS score (r = 1.483, P 0.01), and a positive correlation between serum PTX3 level and Mrs score (r = 1.299, P 0.01). 30 cases of disability (Mrs score 鈮，

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