帕金森病靜止性震顫腦功能連接的功能磁共振成像研究
發(fā)布時(shí)間：2018-07-17 20:46
【摘要】：背景： 隨著我國人口老齡化速度的加快,帕金森病(PD)的發(fā)病率和患病率越來越高。目前PD的發(fā)病機(jī)制尚未明確,但它嚴(yán)重影響著人們的生活質(zhì)量。臨床上采用多種方法治療PD,但效果仍不理想,因此實(shí)現(xiàn)對(duì)PD的診斷是十分重要的。功能磁共振(fMRI)由于具有較高的時(shí)間和空間分辨率,且具有無創(chuàng)性,成為目前診斷PD的重要手段之一。 目的： 利用fMRI研究靜息狀態(tài)下PD震顫患者與健康對(duì)照者之間的腦部功能連接的差異,初步探討PD震顫患者靜息狀態(tài)下的腦功能活動(dòng)特點(diǎn)。 方法： 選擇19例PD震顫患者與20例健康對(duì)照者進(jìn)行靜息態(tài)腦功能磁共振成像,采用Siemens Avanto1.5T磁共振,使用標(biāo)準(zhǔn)正交頭顱線圈。 磁共振頭部橫軸位掃描,定位線置于眉弓連線水平,解剖圖像采用T1加權(quán)三維快速擾相梯度翻轉(zhuǎn)恢復(fù)(3D-SPGR)序列,參數(shù)為TR/TE=24ms/6ms, FA350,層厚0.9mm, FOV=240mm×240mm,矩陣=256×256；fMRI掃描序列采用T2*-EPI-GRE序列,參數(shù)為TR/TE=2000ms/30ms, FA90°,層厚4mm,間隔1mm,FOV=240mm×240mm,矩陣=64×64；掃描時(shí)間為6min。 數(shù)據(jù)處理采用統(tǒng)計(jì)參數(shù)圖(SPM8)、靜息態(tài)fMRI數(shù)據(jù)分析工具包(REST)、靜息態(tài)功能磁共振數(shù)據(jù)處理助手(DPARSFA)等軟件對(duì)功能數(shù)據(jù)進(jìn)行預(yù)處理和統(tǒng)計(jì)學(xué)分析。分別以雙側(cè)蒼白球?yàn)榉N子點(diǎn),采用功能連接(FC)的方法,分析PD震顫患者和健康者腦部FC的差異。 結(jié)果： PD震顫患者中,與右側(cè)蒼白球存在功能連接的腦區(qū)包括小腦扁桃體、左側(cè)額中葉、右側(cè)額中回、中央前回、右側(cè)扣帶回。PD震顫患者中,與左側(cè)蒼白球存在功能連接的腦區(qū)包括額下回、腹前核、雙側(cè)扣帶回、右側(cè)輔助運(yùn)動(dòng)區(qū)。 健康對(duì)照組中,與右側(cè)蒼白球存在功能連接的腦區(qū)包括右側(cè)顳下回、顳中回、額核、腹外側(cè)核、右側(cè)緣上回。健康對(duì)照組中,與左側(cè)蒼白球存在功能連接的腦區(qū)包括邊緣葉、左側(cè)顳下回、右側(cè)丘腦、額中回、左側(cè)中央后回。 與健康對(duì)照組相比,PD震顫患者中的左側(cè)額中眶回與右側(cè)蒼白球存在功能連接增強(qiáng)；與健康對(duì)照組相比,PD震顫患者中與右側(cè)蒼白球功能連接減弱的腦區(qū)包括右側(cè)尾狀核、左側(cè)額上回。與健康對(duì)照組相比,PD震顫患者中與左側(cè)蒼白球功能連接減弱的腦區(qū)包括右側(cè)距狀皮層、左側(cè)島葉、左側(cè)頂下小葉。 結(jié)論： 本研究發(fā)現(xiàn)PD震顫患者組腦內(nèi)神經(jīng)活動(dòng)的功能連接與健康對(duì)照組之間存在差異；PD震顫患者的默認(rèn)網(wǎng)絡(luò)(DMN)和支配運(yùn)動(dòng)的腦區(qū)存在異常。
[Abstract]:Background: with the rapid aging of population in China, the incidence and prevalence of Parkinson's disease (PD) are increasing. At present, the pathogenesis of PD is not clear, but it seriously affects people's quality of life. Many clinical methods are used to treat PD, but the effect is still not satisfactory, so it is very important to realize the diagnosis of PD. Functional magnetic resonance (fMRI) has become one of the most important methods for the diagnosis of PD because of its high spatial and temporal resolution and noninvasive. Objective: to study the difference of brain functional connections between patients with PD tremor and healthy controls with fMRI, and to explore the characteristics of brain function in patients with PD tremor at rest. Methods: 19 patients with PD tremor and 20 healthy controls were selected for resting brain functional magnetic resonance imaging. Siemens Avanto 1.5T magnetic resonance imaging and standard orthogonal head coil were used. Magnetic resonance head axial scan and location line were placed at the level of the line of the eyebrow arch. T1-weighted 3D fast phase gradient inversion recovery (3D-SPGR) sequence was used in the anatomical images. The parameters were TRR / TEN 24ms / 6ms, FA350mm, slice thickness 0.9mm, FOVN 240mm 脳 240mm, matrix 256 脳 256fMRI using T2D- EPI-GRE sequence. The parameters are TRR / T 2000 Ms / 30ms, FA 90 擄, layer thickness 4mm, interval 1mm FOV 240mm 脳 240mm, matrix 64 脳 64, scanning time 6 min. Statistical parameter map (SPM8), rest fMRI data analysis kit (rest) and rest functional magnetic resonance data processing assistant (DPARSFA) were used to preprocess and analyze the data. Using bilateral globus pallidus as seed point, functional junction (FC) was used to analyze the difference of FC in brain between PD tremor patients and healthy subjects. Results: in patients with PD tremor, functional connections with the right globus pallidus included the cerebellar tonsil, left middle frontal lobe, right middle frontal gyrus, precentral gyrus, right cingulate gyrus. The functional connections with the left globus pallidus include subfrontal gyrus, ventral anterior nucleus, bilateral cingulate gyrus, and right auxiliary motor area. In the control group, the functional connections with the right globus pallidus included the right inferior temporal gyrus, middle temporal gyrus, frontal nucleus, ventrolateral nucleus and right superior marginal gyrus. In the healthy control group, functional connections with the left globus pallidus included the marginal lobe, the left subtemporal gyrus, the right thalamus, the middle frontal gyrus, and the left posterior central gyrus. The functional connections between the left middle frontal orbital gyrus and the right globus pallidus were enhanced in PD tremor patients compared with the healthy controls, and the regions of the brain with reduced functional connections with the right globus pallidus included the right caudate nucleus in PD tremors compared with the healthy controls. Left superior frontal gyrus. In PD tremors patients with PD tremors, the areas with reduced functional connections to the left globus pallidus included the right talocortex, the left insular lobe, and the left inferior parietal lobule. Conclusion: this study found that there were differences between the functional connections of neural activity in PD tremor group and the healthy control group. The default network (DMN) of PD tremor patients and the regions of brain innervated motion were abnormal.
【學(xué)位授予單位】：廣州中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R742.5;R445.2
[Abstract]:Background: with the rapid aging of population in China, the incidence and prevalence of Parkinson's disease (PD) are increasing. At present, the pathogenesis of PD is not clear, but it seriously affects people's quality of life. Many clinical methods are used to treat PD, but the effect is still not satisfactory, so it is very important to realize the diagnosis of PD. Functional magnetic resonance (fMRI) has become one of the most important methods for the diagnosis of PD because of its high spatial and temporal resolution and noninvasive. Objective: to study the difference of brain functional connections between patients with PD tremor and healthy controls with fMRI, and to explore the characteristics of brain function in patients with PD tremor at rest. Methods: 19 patients with PD tremor and 20 healthy controls were selected for resting brain functional magnetic resonance imaging. Siemens Avanto 1.5T magnetic resonance imaging and standard orthogonal head coil were used. Magnetic resonance head axial scan and location line were placed at the level of the line of the eyebrow arch. T1-weighted 3D fast phase gradient inversion recovery (3D-SPGR) sequence was used in the anatomical images. The parameters were TRR / TEN 24ms / 6ms, FA350mm, slice thickness 0.9mm, FOVN 240mm 脳 240mm, matrix 256 脳 256fMRI using T2D- EPI-GRE sequence. The parameters are TRR / T 2000 Ms / 30ms, FA 90 擄, layer thickness 4mm, interval 1mm FOV 240mm 脳 240mm, matrix 64 脳 64, scanning time 6 min. Statistical parameter map (SPM8), rest fMRI data analysis kit (rest) and rest functional magnetic resonance data processing assistant (DPARSFA) were used to preprocess and analyze the data. Using bilateral globus pallidus as seed point, functional junction (FC) was used to analyze the difference of FC in brain between PD tremor patients and healthy subjects. Results: in patients with PD tremor, functional connections with the right globus pallidus included the cerebellar tonsil, left middle frontal lobe, right middle frontal gyrus, precentral gyrus, right cingulate gyrus. The functional connections with the left globus pallidus include subfrontal gyrus, ventral anterior nucleus, bilateral cingulate gyrus, and right auxiliary motor area. In the control group, the functional connections with the right globus pallidus included the right inferior temporal gyrus, middle temporal gyrus, frontal nucleus, ventrolateral nucleus and right superior marginal gyrus. In the healthy control group, functional connections with the left globus pallidus included the marginal lobe, the left subtemporal gyrus, the right thalamus, the middle frontal gyrus, and the left posterior central gyrus. The functional connections between the left middle frontal orbital gyrus and the right globus pallidus were enhanced in PD tremor patients compared with the healthy controls, and the regions of the brain with reduced functional connections with the right globus pallidus included the right caudate nucleus in PD tremors compared with the healthy controls. Left superior frontal gyrus. In PD tremors patients with PD tremors, the areas with reduced functional connections to the left globus pallidus included the right talocortex, the left insular lobe, and the left inferior parietal lobule. Conclusion: this study found that there were differences between the functional connections of neural activity in PD tremor group and the healthy control group. The default network (DMN) of PD tremor patients and the regions of brain innervated motion were abnormal.
【學(xué)位授予單位】：廣州中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R742.5;R445.2
【參考文獻(xiàn)】
相關(guān)期刊論文 前10條
1 倫學(xué)慶,張春芬,章翔;實(shí)驗(yàn)性帕金森病血漿及紋狀體興奮性氨基酸變化及其意義[J];濟(jì)寧醫(yī)學(xué)院學(xué)報(bào);1998年01期
2 王嵐;孫圣剛;;帕金森病發(fā)病機(jī)制研究進(jìn)展[J];臨床內(nèi)科雜志;2006年06期
3 張克忠;蔣雨平;丁新生;;應(yīng)用蛋白酶體抑制劑Lactacystin建立有Lewy體的帕金森病大鼠模型[J];臨床神經(jīng)病學(xué)雜志;2006年05期
4 楊輝;左O ;劉雯;;Parkin、PINK1、DJ-1和線粒體功能障礙與帕金森病[J];生命科學(xué);2010年10期
5 曾文雙,褚曉凡;震顫的生理機(jī)制及診斷和肌電圖特點(diǎn)[J];中國臨床康復(fù);2005年33期
6 李飛平;沈加林;許建榮;劉佳;陳增愛;趙子周;;彌散張量成像對(duì)早期帕金森病的研究?jī)r(jià)值[J];中國醫(yī)學(xué)計(jì)算機(jī)成像雜志;2010年04期
7 張冬齊;徐江平;;抗氧化劑對(duì)帕金森病的保護(hù)作用及機(jī)制的進(jìn)展[J];醫(yī)學(xué)綜述;2006年02期
8 黃桂平;;帕金森病的臨床研究及展望[J];醫(yī)學(xué)綜述;2008年13期
9 鄭旭寧,朱雄超,阮凌翔,張玲菊,袁敏,商德勝,柳揚(yáng);MRS study on lentiform nucleus in idiopathic Parkinson's disease with unilateral symptoms[J];Journal of Zhejiang University Science;2004年02期
10 熊s，
本文編號(hào)：2130888
本文鏈接：http://sikaile.net/yixuelunwen/shenjingyixue/2130888.html
最近更新
教材專著
