急性腦梗死患者血清視黃醇結(jié)合蛋白水平與頸動(dòng)脈粥樣硬化斑塊的相關(guān)性研究
發(fā)布時(shí)間：2018-07-16 19:23
【摘要】：目的探討急性腦梗死(ACI)患者頸動(dòng)脈粥樣硬化性斑塊與視黃醇結(jié)合蛋白(RBP)含量的關(guān)系。方法選取96例ACI患者(ACI組)和95例正常對(duì)照者(對(duì)照組),檢測(cè)血清RBP水平;同時(shí)檢測(cè)ACI組和對(duì)照組患者血清尿酸(UA)和血漿D-二聚體(DD)、纖維蛋白原(FIB)水平。對(duì)于ACI患者結(jié)合其頸動(dòng)脈超聲檢查結(jié)果,分為無(wú)斑塊組(41例)、頸動(dòng)脈穩(wěn)定斑塊組(28例)和頸動(dòng)脈不穩(wěn)定斑塊組(27例);比較各組血清RBP水平。結(jié)果 ACI組血清RBP水平顯著高于正常對(duì)照組(P0.05)。在ACI患者中,頸動(dòng)脈穩(wěn)定斑塊組和不穩(wěn)定斑塊組的血清RBP水平較無(wú)斑塊組明顯升高(均P0.05);頸動(dòng)脈不穩(wěn)定斑塊組血清RBP水平顯著高于穩(wěn)定斑塊組(P0.05)。線性相關(guān)分析表明,RBP水平和UA、DD和FIB水平無(wú)明顯相關(guān)性(r=0.192,r=0.088,r=0.096,均P0.05)。Logistic回歸分析結(jié)果顯示,RBP是發(fā)生頸動(dòng)脈粥樣斑塊的危險(xiǎn)因素(OR=2.769,95%CI 0.007-0.722)。結(jié)論血清RBP可能是動(dòng)脈硬化形成的一個(gè)重要標(biāo)志物,并且可能與ACI患者動(dòng)脈粥樣硬化斑塊的穩(wěn)定性密切相關(guān)。
[Abstract]:Objective to investigate the relationship between carotid atherosclerotic plaque and retinol binding protein (RBP) in patients with acute cerebral infarction (ACI). Methods Serum RBP levels, serum uric acid (UA), plasma D-dimer (DD) and fibrinogen (FIB) levels were measured in 96 patients with ACI and 95 normal controls. Patients with ACI were divided into 4 groups: no plaque group (41 cases), carotid artery stable plaque group (28 cases) and carotid artery unstable plaque group (27 cases). Results the serum RBP level in ACI group was significantly higher than that in normal control group (P0.05). In ACI patients, the serum RBP level in carotid stable plaque group and unstable plaque group was significantly higher than that in non-plaque group (P0.05), and the serum RBP level in carotid unstable plaque group was significantly higher than that in stable plaque group (P0.05). Linear correlation analysis showed that there was no significant correlation between RBP level and DD and FIB levels (r = 0.192). Logistic regression analysis showed that RBP was a risk factor for carotid atherosclerotic plaques (OR2.769 / 95 CI 0.007-0.722). Conclusion Serum RBP may be an important marker of atherosclerosis and may be closely related to the stability of atherosclerotic plaques in ACI patients.
【作者單位】： 南通大學(xué)第三附屬醫(yī)院/無(wú)錫市第三人民醫(yī)院神經(jīng)內(nèi)科;
【分類(lèi)號(hào)】：R743.33
本文編號(hào)：2127424
[Abstract]:Objective to investigate the relationship between carotid atherosclerotic plaque and retinol binding protein (RBP) in patients with acute cerebral infarction (ACI). Methods Serum RBP levels, serum uric acid (UA), plasma D-dimer (DD) and fibrinogen (FIB) levels were measured in 96 patients with ACI and 95 normal controls. Patients with ACI were divided into 4 groups: no plaque group (41 cases), carotid artery stable plaque group (28 cases) and carotid artery unstable plaque group (27 cases). Results the serum RBP level in ACI group was significantly higher than that in normal control group (P0.05). In ACI patients, the serum RBP level in carotid stable plaque group and unstable plaque group was significantly higher than that in non-plaque group (P0.05), and the serum RBP level in carotid unstable plaque group was significantly higher than that in stable plaque group (P0.05). Linear correlation analysis showed that there was no significant correlation between RBP level and DD and FIB levels (r = 0.192). Logistic regression analysis showed that RBP was a risk factor for carotid atherosclerotic plaques (OR2.769 / 95 CI 0.007-0.722). Conclusion Serum RBP may be an important marker of atherosclerosis and may be closely related to the stability of atherosclerotic plaques in ACI patients.
【作者單位】： 南通大學(xué)第三附屬醫(yī)院/無(wú)錫市第三人民醫(yī)院神經(jīng)內(nèi)科;
【分類(lèi)號(hào)】：R743.33
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