急性缺血性腦卒中患者BPV與IMT的關(guān)系及對(duì)預(yù)后的影響
發(fā)布時(shí)間:2018-07-15 19:52
【摘要】:目的:探討不同影像學(xué)分型的急性缺血性卒中血壓變異性和頸動(dòng)脈內(nèi)膜中層厚度之間的關(guān)系及其對(duì)預(yù)后的影響。方法連續(xù)選取皖南醫(yī)學(xué)院附屬弋磯山醫(yī)院神經(jīng)內(nèi)科2014年9月至2015年6月住院的治療的急性缺血性卒中患者136例,登記患者基本情況,根據(jù)患者入院后的磁共振彌散加權(quán)成像(diffusion weighted imaging,DWI)的結(jié)果進(jìn)行影像學(xué)分型,并以頸動(dòng)脈內(nèi)膜中層厚度(intima media thickness,IMT)為切點(diǎn),將患者分為IMT1mm組、1mm≤IMT1.5mm組和IMT≥1.5mm組。同時(shí)采用24h動(dòng)態(tài)血壓監(jiān)測(cè)儀(ambulatory blood pressure monitoring,ABPM)監(jiān)測(cè)血壓,選擇24h、白晝及夜間的收縮壓標(biāo)準(zhǔn)差(systolic blood pressure standard deviation,SSD)和舒張壓標(biāo)準(zhǔn)差(diastolic blood pressure standard deviation,DSD)代表血壓變異性(blood pressure variability,BPV),分析IMT與BPV間的關(guān)系并研究二者對(duì)不同影像學(xué)分型的急性CIS患者預(yù)后的影響。結(jié)果:1.高血壓在IMT正常組、增厚組及斑塊組出現(xiàn)的頻率逐漸升高,差異有統(tǒng)計(jì)學(xué)意義(P0.05),同IMT正常組相比,IMT增厚組與頸動(dòng)脈斑塊組的年齡和FGB均較高,同IMT正常組比較,增厚組的LDL增高,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。而性別、糖尿病、冠心病、吸煙、UA、TG、HDL等各組間比較均無(wú)統(tǒng)計(jì)學(xué)差異(P0.05)。與IMT正常組比較,IMT增厚組和頸動(dòng)脈斑塊組的24h SSD、24h DSD、d SSD、d DSD、n DSD的值均較大,差異有統(tǒng)計(jì)學(xué)意義(P0.05),與IMT增厚組相比,頸動(dòng)脈斑塊組的24h SSD的值較大,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。2.通過(guò)IMT與各時(shí)段(24h、白晝、夜間)的平均血壓及BPV的相關(guān)性分析可以看出,IMT與24h SBP、d SBP、24h SSD、24h DSD、d SSD均呈正相關(guān),其中與24h SBP(r=0.403,P=0.008)、24h SSD(r=0.487,P=0.017)的相關(guān)性較強(qiáng)。3.預(yù)后不良組與預(yù)后良好組比較,年齡、高血壓病、糖尿病、24h SSD、24h DSD、d SSD、d DSD、FGB的差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。余各危險(xiǎn)因素均無(wú)統(tǒng)計(jì)學(xué)意義,結(jié)果提示,年齡、高血壓病、糖尿病、24h SSD、24h DSD、d SSD、d DSD、FGB是急性CIS患者6個(gè)月時(shí)預(yù)后的影響因素。繼續(xù)進(jìn)行Logistic回歸分析,結(jié)果發(fā)現(xiàn)只有24h SSD、d DSD與6個(gè)月預(yù)后有關(guān),其余各因素與預(yù)后關(guān)系不明顯,因此,僅24h SSD、d DSD是急性CIS患者6個(gè)月預(yù)后不良的獨(dú)立影響因素。4.與后循環(huán)梗死組比較,前循環(huán)皮質(zhì)梗死組、基底節(jié)區(qū)梗死組的24h SSD增高,與放射冠區(qū)梗死組和后循環(huán)梗死組相比,基底節(jié)區(qū)梗死組的d SSD增高,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。與單發(fā)梗死相比,多灶梗死的24h SSD、24h DSD、d SSD、n SSD、IMT均高于單發(fā)梗死組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:1.急性缺血性卒中患者的平均血壓及血壓變異性與頸動(dòng)脈內(nèi)膜中層厚度增加有關(guān)。2.24h收縮壓變異性和白晝舒張壓變異性是急性缺血性卒中患者預(yù)后的獨(dú)立影響因素。3.不同影像學(xué)分型的急性缺血性卒中患者的血壓變異性不同。
[Abstract]:Objective: to investigate the relationship between blood pressure variability and carotid intima-media thickness in acute ischemic stroke with different imaging types and its influence on prognosis. Methods 136 patients with acute ischemic stroke who were hospitalized from September 2014 to June 2015 in Department of Neurology, affiliated to Southern Anhui Medical College, were selected to register the basic conditions of the patients. According to the results of diffusion weighted (diffusion weighted imaging (DWI) after admission, the patients were divided into IMT 1 mm 鈮,
本文編號(hào):2125199
[Abstract]:Objective: to investigate the relationship between blood pressure variability and carotid intima-media thickness in acute ischemic stroke with different imaging types and its influence on prognosis. Methods 136 patients with acute ischemic stroke who were hospitalized from September 2014 to June 2015 in Department of Neurology, affiliated to Southern Anhui Medical College, were selected to register the basic conditions of the patients. According to the results of diffusion weighted (diffusion weighted imaging (DWI) after admission, the patients were divided into IMT 1 mm 鈮,
本文編號(hào):2125199
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