急性缺血性腦卒中患者BPV與IMT的關系及對預后的影響
發(fā)布時間:2018-07-15 19:52
【摘要】:目的:探討不同影像學分型的急性缺血性卒中血壓變異性和頸動脈內膜中層厚度之間的關系及其對預后的影響。方法連續(xù)選取皖南醫(yī)學院附屬弋磯山醫(yī)院神經內科2014年9月至2015年6月住院的治療的急性缺血性卒中患者136例,登記患者基本情況,根據患者入院后的磁共振彌散加權成像(diffusion weighted imaging,DWI)的結果進行影像學分型,并以頸動脈內膜中層厚度(intima media thickness,IMT)為切點,將患者分為IMT1mm組、1mm≤IMT1.5mm組和IMT≥1.5mm組。同時采用24h動態(tài)血壓監(jiān)測儀(ambulatory blood pressure monitoring,ABPM)監(jiān)測血壓,選擇24h、白晝及夜間的收縮壓標準差(systolic blood pressure standard deviation,SSD)和舒張壓標準差(diastolic blood pressure standard deviation,DSD)代表血壓變異性(blood pressure variability,BPV),分析IMT與BPV間的關系并研究二者對不同影像學分型的急性CIS患者預后的影響。結果:1.高血壓在IMT正常組、增厚組及斑塊組出現的頻率逐漸升高,差異有統(tǒng)計學意義(P0.05),同IMT正常組相比,IMT增厚組與頸動脈斑塊組的年齡和FGB均較高,同IMT正常組比較,增厚組的LDL增高,差異有統(tǒng)計學意義(P0.05)。而性別、糖尿病、冠心病、吸煙、UA、TG、HDL等各組間比較均無統(tǒng)計學差異(P0.05)。與IMT正常組比較,IMT增厚組和頸動脈斑塊組的24h SSD、24h DSD、d SSD、d DSD、n DSD的值均較大,差異有統(tǒng)計學意義(P0.05),與IMT增厚組相比,頸動脈斑塊組的24h SSD的值較大,差異有統(tǒng)計學意義(P0.05)。2.通過IMT與各時段(24h、白晝、夜間)的平均血壓及BPV的相關性分析可以看出,IMT與24h SBP、d SBP、24h SSD、24h DSD、d SSD均呈正相關,其中與24h SBP(r=0.403,P=0.008)、24h SSD(r=0.487,P=0.017)的相關性較強。3.預后不良組與預后良好組比較,年齡、高血壓病、糖尿病、24h SSD、24h DSD、d SSD、d DSD、FGB的差異均有統(tǒng)計學意義(P0.05)。余各危險因素均無統(tǒng)計學意義,結果提示,年齡、高血壓病、糖尿病、24h SSD、24h DSD、d SSD、d DSD、FGB是急性CIS患者6個月時預后的影響因素。繼續(xù)進行Logistic回歸分析,結果發(fā)現只有24h SSD、d DSD與6個月預后有關,其余各因素與預后關系不明顯,因此,僅24h SSD、d DSD是急性CIS患者6個月預后不良的獨立影響因素。4.與后循環(huán)梗死組比較,前循環(huán)皮質梗死組、基底節(jié)區(qū)梗死組的24h SSD增高,與放射冠區(qū)梗死組和后循環(huán)梗死組相比,基底節(jié)區(qū)梗死組的d SSD增高,差異有統(tǒng)計學意義(P0.05)。與單發(fā)梗死相比,多灶梗死的24h SSD、24h DSD、d SSD、n SSD、IMT均高于單發(fā)梗死組,差異有統(tǒng)計學意義(P0.05)。結論:1.急性缺血性卒中患者的平均血壓及血壓變異性與頸動脈內膜中層厚度增加有關。2.24h收縮壓變異性和白晝舒張壓變異性是急性缺血性卒中患者預后的獨立影響因素。3.不同影像學分型的急性缺血性卒中患者的血壓變異性不同。
[Abstract]:Objective: to investigate the relationship between blood pressure variability and carotid intima-media thickness in acute ischemic stroke with different imaging types and its influence on prognosis. Methods 136 patients with acute ischemic stroke who were hospitalized from September 2014 to June 2015 in Department of Neurology, affiliated to Southern Anhui Medical College, were selected to register the basic conditions of the patients. According to the results of diffusion weighted (diffusion weighted imaging (DWI) after admission, the patients were divided into IMT 1 mm 鈮,
本文編號:2125199
[Abstract]:Objective: to investigate the relationship between blood pressure variability and carotid intima-media thickness in acute ischemic stroke with different imaging types and its influence on prognosis. Methods 136 patients with acute ischemic stroke who were hospitalized from September 2014 to June 2015 in Department of Neurology, affiliated to Southern Anhui Medical College, were selected to register the basic conditions of the patients. According to the results of diffusion weighted (diffusion weighted imaging (DWI) after admission, the patients were divided into IMT 1 mm 鈮,
本文編號:2125199
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