本文選題：急性腦梗死 + 靜脈溶栓　； 參考：《第三軍醫(yī)大學(xué)學(xué)報(bào)》2017年17期

【摘要】：目的比較5種評(píng)分系統(tǒng)對(duì)不同時(shí)間窗的急性腦梗死靜脈溶栓后出血轉(zhuǎn)化(hemorrhagic transformation,HT)風(fēng)險(xiǎn)的預(yù)測(cè)價(jià)值。方法對(duì)2014年1月至2016年12月對(duì)不同時(shí)間窗內(nèi)僅接受重組組織型纖溶酶原激活物(recombinant tissue-type plasminogen activator,rt-PA)靜脈溶栓的243例急性腦梗死患者進(jìn)行單中心、回顧性研究。應(yīng)用HAT評(píng)分、GRASPS評(píng)分、SEDAN評(píng)分、MSS評(píng)分及SITS評(píng)分量表進(jìn)行測(cè)評(píng),觀察5種評(píng)分系統(tǒng)與不同時(shí)間窗內(nèi)的急性腦梗死接受靜脈溶栓后出現(xiàn)HT的關(guān)系;應(yīng)用ROC曲線下面積大小比較5種評(píng)分系統(tǒng)在不同時(shí)間窗靜脈溶栓后出HT的預(yù)測(cè)能力。結(jié)果針對(duì)不同時(shí)間窗,比較5種評(píng)分系統(tǒng)ROC曲線下面積,結(jié)果顯示:≤3 h時(shí)GRASPS及HAT評(píng)分系統(tǒng)的ROC曲線下面積(分別為0.698、0.619)高于其他評(píng)分系統(tǒng);3~4.5 h時(shí),SEDAN評(píng)分、HAT評(píng)分(ROC面積分別為0.744,0.719)優(yōu)于其他評(píng)分系統(tǒng)(P0.05);4.5~6 h時(shí),HAT評(píng)分系統(tǒng)(ROC曲線下面積為0.676)優(yōu)于其他評(píng)分系統(tǒng)。結(jié)論 5種評(píng)分系統(tǒng)對(duì)所有時(shí)間窗靜脈溶栓后HT的發(fā)生有較好的預(yù)測(cè)能力。在不同時(shí)間窗,特別是在4.5 h內(nèi),HAT評(píng)分系統(tǒng)對(duì)HT風(fēng)險(xiǎn)預(yù)測(cè)可能擁有相對(duì)較好的預(yù)測(cè)價(jià)值。
[Abstract]:Objective to compare the predictive value of five scoring systems for hemorrhagic transformation HT in acute cerebral infarction with different time windows. Methods from January 2014 to December 2016, a single center study was performed in 243 patients with acute cerebral infarction who received only recombinant tissue plasminogen activator (recombinant tissue-type plasminogen activator rt-PA) in different time windows. To evaluate the effects of different time windows on HT in patients with acute cerebral infarction after intravenous thrombolytic therapy, the patients were evaluated with hat score, grass ASPS score, SEDAN score, MSS score and site score scale. The results were as follows: (1) the relationship between the five scoring systems and the occurrence of HT in acute cerebral infarction after intravenous thrombolytic therapy was observed. The area size under the ROC curve was used to compare the predictive ability of 5 scoring systems for HT after intravenous thrombolysis at different time windows. Results according to different time windows, the area under ROC curve of five scoring systems was compared. The results showed that the area under the ROC curve of GrASPS and hat scoring system at 鈮，

本文編號(hào)：2116755