本文選題：腦白質(zhì)疏松癥 + 情緒　； 參考：《安徽醫(yī)科大學(xué)》2017年碩士論文

【摘要】：研究目的腦白質(zhì)疏松(LA)作為腦小血管病的一種,受到的關(guān)注及研究越來越多,目前大量研究證實(shí)LA影響認(rèn)知功能。本研究利用不同效價(jià)的情緒圖片學(xué)習(xí)-再認(rèn)任務(wù)比較LA患者與正常老年人的情緒記憶改變的不同,初步比較不同情緒效價(jià)對LA患者的記憶的損害特點(diǎn),并進(jìn)一步探究其改變可能發(fā)生的神經(jīng)機(jī)制。研究方法選取2015年7月至2016年2月在安徽醫(yī)科大學(xué)第三附屬醫(yī)院神經(jīng)內(nèi)科就診的門診及住院的LA患者(LA組)和健康對照者(HC組)各24例,分別進(jìn)行頭顱MRI掃描及包括簡易智能精神狀態(tài)量表(MMSE)、詞匯流暢性測試(Verbal fluency test,VFT)、數(shù)字廣度測試(digital span,DS)、漢密爾頓焦慮量表(HAMA)、漢密爾頓抑郁量表(HAND)測試等神經(jīng)心理學(xué)測試,使用情緒圖片學(xué)習(xí)-再認(rèn)任務(wù)對兩組進(jìn)行情緒記憶測試,評估其認(rèn)知功能狀態(tài),并按照Fazekas的評分標(biāo)準(zhǔn)將LA嚴(yán)重程度分為3級(輕、中、重),分析患者認(rèn)知功能損害與LA疾病嚴(yán)重程度的相關(guān)性。研究結(jié)果腦白質(zhì)疏松患者組與健康對照組在年齡、受教育程度、神經(jīng)心理背景測試差異無統(tǒng)計(jì)學(xué)意義(p0.05)。在學(xué)習(xí)階段中,LA組評分情緒圖片的負(fù)性成績評分與HC組相比有下降[分別為HC組:(12.75±2.02)分;LA組:(11.63±1.81)分],差異有統(tǒng)計(jì)學(xué)意義(p0.05);正性和中性成績評分中HC組[分別為:正性(11.38±3.25)分;中性(12.75±2.86)分]與LA組[分別為:正性(10.42±2.30)分;中性(12.87±2.29)分]相比,差異無統(tǒng)計(jì)學(xué)意義(p0.05)。在情緒記憶測試的再認(rèn)階段,與HC組相比,LA組總情緒圖片再認(rèn)正確得分明顯下降[分別為LA組:(33.67±7.10)分;HC組:(38.08+±5.45)分],差異有統(tǒng)計(jì)學(xué)意義(p0.05);LA組對不同效價(jià)情緒圖片再認(rèn)存在分離現(xiàn)象,相比于HC組[分別為:正性(12.79±2.17)分;中性(12.08±2.59)分],LA組在正性和中性圖片再認(rèn)[分別為:正性(11.04±2.40)分;中性(10.42±2.93)分]中,正性和中性情緒圖片再認(rèn)正確得分顯著下降,差異有統(tǒng)計(jì)學(xué)意義(p0.05);而兩組負(fù)性圖片再認(rèn)[分別為LA組:(13.20±1.86)分;HC組(12.20±2.65)分],差異無統(tǒng)計(jì)學(xué)意義(p0.05)。且在學(xué)習(xí)階段,負(fù)性成績評分與腦白質(zhì)疏松嚴(yán)重程度呈負(fù)相關(guān)(r=-0.308,p=0.033);在再認(rèn)階段,總情緒圖片再認(rèn)正確得分、正性以及中性情緒圖片再認(rèn)正確得分與腦白質(zhì)疏松的嚴(yán)重程度亦呈負(fù)相關(guān)(r=-0.308,p=0.033;r=-0.426,p=0.003;r=-0353,p=0.014)。研究結(jié)論LA患者與認(rèn)知功能密切相關(guān),LA患者的情緒記憶損害中,主要表現(xiàn)為負(fù)性情緒記憶相對保留,而負(fù)性情緒評估、正性和中性情緒記憶受損,且情緒記憶的損害嚴(yán)重程度與LA程度相關(guān),表明不同效價(jià)情緒記憶對LA的影響依賴不同的神經(jīng)機(jī)制。
[Abstract]:Objective Leukoaraiosis (LA) has attracted more and more attention as a kind of small cerebral vascular disease. A large number of studies have confirmed that LA affects cognitive function. In this study, we compared the changes of emotional memory between LA patients and normal elderly patients by using different titer emotional picture learning and recognition task, and compared the damage characteristics of LA patients with different emotional titers to the memory of LA patients. And further explore the possible neural mechanism of its changes. Methods A total of 24 LA patients (LA group) and 24 healthy controls (HC group) from July 2015 to February 2016 in Department of Neurology, third affiliated Hospital of Anhui Medical University, were selected. Cranial MRI scans and neuropsychological tests were performed, including the mini-mental state scale (MMSE), the verbal fluency test (VFT), the number span test (digital Spanta-DS), the Hamilton anxiety scale (Hama), the Hamilton Depression scale (hand), and other neuropsychological tests. Emotional picture learning-recognition tasks were used to test emotional memory in two groups to assess their cognitive function, and to classify LA severity into three levels according to Fazekas score (mild, moderate, moderate). To analyze the correlation between cognitive impairment and the severity of LA disease. Results there was no significant difference in age, education level and neuropsychological background between patients with leukoaraiosis and healthy controls (p0.05). In the study stage, the scores of negative scores of emotional pictures in group A were lower than those in group HC [(12.75 鹵2.02) vs (11.63 鹵1.81) in group HC, respectively], the difference was significant (p0.05), the scores of positive and neutral scores in group HC [11.38 鹵3.25] were significantly lower than those in group HC (P < 0.05), but in group A (12.75 鹵2.02) and group LA (11.63 鹵1.81), the scores of positive score and neutral score were (11.38 鹵3.25), respectively. There was no significant difference between the neutral group (12.75 鹵2.86) and the LA group [positive (10.42 鹵2.30); neutral (12.87 鹵2.29)] (p0.05). In the recognition stage of emotional memory test, the scores of recognition accuracy of total emotional picture in LA group were significantly lower than those in HC group [LA group: 33.67 鹵7.10] and HC group: 38.08 鹵5.45, respectively. The difference was statistically significant (p0.05). Compared with HC group (12.79 鹵2.17) and neutral (12.08 鹵2.59), the scores of positive and neutral picture recognition [11.04 鹵2.40; neutral (10.42 鹵2.93)] decreased significantly in LA group. The difference was statistically significant (p0.05), but there was no significant difference in negative picture recognition between the two groups [LA group: (13.20 鹵1.86) points vs (12.20 鹵2.65) points]. At the learning stage, negative scores were negatively correlated with the severity of leukoaraiosis (r-0.308p0. 033), and at the recognition stage, the recognition scores of the total emotional pictures were correct. The scores of positive and neutral emotional picture recognition were also negatively correlated with the severity of leukoaraiosis (r = 0.308). Conclusion the emotional memory impairment of LA patients is closely related to cognitive function. The main manifestation of emotional memory impairment is negative emotional memory, but negative emotional assessment, positive and neutral emotional memory impairment. The severity of emotional memory damage was related to the degree of LA, indicating that the effect of emotional memory on LA was dependent on different neural mechanisms.
【學(xué)位授予單位】：安徽醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R743

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 李雪;朱幼玲;席春華;董斌;張婷婷;翟登月;唐敏;;原發(fā)性失眠患者的情緒記憶改變[J];中華行為醫(yī)學(xué)與腦科學(xué)雜志;2015年10期

2 陳建淮;姚志劍;趙可;閻銳;花玲玲;賈鳳南;韋秋香;盧青;;雙相抑郁患者腦白質(zhì)網(wǎng)絡(luò)介數(shù)中心度屬性研究[J];中華行為醫(yī)學(xué)與腦科學(xué)雜志;2015年08期

3 牛寶豐;尹曉明;周衛(wèi)東;;腦白質(zhì)變性與認(rèn)知障礙[J];中國神經(jīng)免疫學(xué)和神經(jīng)病學(xué)雜志;2014年04期

4 王衛(wèi)華;徐均陶;張永葆;馬慧;張歡;;腦白質(zhì)疏松癥患者情緒認(rèn)知功能損害的研究[J];蚌埠醫(yī)學(xué)院學(xué)報(bào);2014年02期

5 袁俊亮;王雙坤;彭朋;郭曉娟;顧華;李淑娟;秦偉;胡文立;;腦白質(zhì)疏松癥患者認(rèn)知功能障礙的特征分析[J];中華醫(yī)學(xué)雜志;2012年03期

6 于學(xué)英;王桂紅;管小亭;劉云;王素香;劉志忠;王擁軍;;門診非癡呆患者單純腦白質(zhì)疏松的年齡特征[J];中華內(nèi)科雜志;2010年06期

7 邱菊;汪凱;程懷東;;缺血性腦白質(zhì)病變患者前瞻性記憶損害[J];中華神經(jīng)科雜志;2010年03期

8 吳潤果;羅躍嘉;;情緒記憶的神經(jīng)基礎(chǔ)[J];心理科學(xué)進(jìn)展;2008年03期

9 席春華;汪凱;牛朝詩;傅先明;李湄珍;李曉駟;朱春燕;杜靜;;前額葉損傷患者的社會(huì)認(rèn)知障礙[J];中華神經(jīng)科雜志;2006年10期

10 郭洪志;腦白質(zhì)疏松癥[J];臨床神經(jīng)病學(xué)雜志;2002年01期

，

本文編號(hào)：2092897