本文選題：癲癇 + 記憶功能��； 參考：《福建醫(yī)科大學(xué)》2014年碩士論文

【摘要】：目的 通過對(duì)癲癇患者及健康對(duì)照者臨床記憶功能評(píng)估、對(duì)比，探索癲癇患者記憶損害特點(diǎn)，同時(shí)探討多種臨床因素（性別、年齡、起病年齡、文化程度、病程、發(fā)作頻率、發(fā)作持續(xù)時(shí)間等）與記憶功能的相關(guān)性，探討影響癲癇患者記憶功能的相關(guān)因素，探尋改善癲癇患者記憶功能或降低記憶損害的方法。 材料與方法 對(duì)102例癲癇患者及75例性別、年齡、文化程度相匹配的健康對(duì)照者同時(shí)進(jìn)行臨床記憶、生活質(zhì)量、焦慮抑郁等量表測(cè)定，比較病例組和對(duì)照組這些指標(biāo)的差別。同時(shí)詳細(xì)搜集各個(gè)癲癇患者的臨床資料，包括：性別、年齡、起病年齡、文化程度、病程、發(fā)作頻率、發(fā)作持續(xù)時(shí)間、有無用藥及用藥數(shù)量，以及發(fā)作間期腦電圖特點(diǎn)、頭顱MRI或頭顱CT等檢查結(jié)果，并對(duì)這些臨床因素與記憶功能進(jìn)行相關(guān)分析。 結(jié)果 1.癲癇患者臨床記憶包括：記憶商、指向記憶、聯(lián)想學(xué)習(xí)、圖像自由回憶、無意義圖形再認(rèn)、人像特點(diǎn)回憶等均低于正常對(duì)照組（p0.01）。 2.癲癇患者生活質(zhì)量評(píng)估顯示生理、心理領(lǐng)域低于正常對(duì)照組（p0.05）。 3.單因素方差分析：性別、起病年齡、病程、發(fā)作頻率、持續(xù)時(shí)間、用藥情況與記憶商之間無明顯相關(guān)（p0.05）。 4.方差分析顯示文化程度較低的癲癇患者記憶功能更容易受損。 5.多元回歸分析顯示記憶商的影響因素是生活質(zhì)量和文化程度。 6.影響癲癇患者生活質(zhì)量的因素依次是焦慮、文化程度、病程、發(fā)病頻率。 結(jié)論 1.年輕癲癇患者記憶功能受損。 2.影響年輕癲癇患者臨床記憶主要因素是生活質(zhì)量和文化程度。 3.焦慮、文化程度、發(fā)病頻率、病程是癲癇患者生活質(zhì)量的影響因素 4.改善癲癇患者的生活質(zhì)量，，尤其是焦慮，對(duì)降低記憶功能損害可能有一定價(jià)值。
[Abstract]:Objective to evaluate the clinical memory function of epileptic patients and healthy controls, and to explore the characteristics of memory impairment in epileptic patients, and to explore various clinical factors (sex, age, onset age, education level, course of disease). The relationship between seizure frequency, duration of seizure and memory function was discussed. The related factors affecting the memory function of epileptic patients were discussed, and the methods to improve the memory function or reduce the memory impairment in epileptic patients were explored. Materials and methods Clinical memory, quality of life, anxiety and depression were measured simultaneously in 102 epileptic patients and 75 healthy controls matched with sex, age and education. The difference of these indexes between the case group and the control group was compared. At the same time, the clinical data of each epileptic patient were collected in detail, including: sex, age, age of onset, education, course of disease, frequency of attack, duration of seizure, availability and quantity of medication, and characteristics of electroencephalogram during interictal period. Cranial MRI and CT were used to analyze the correlation between these clinical factors and memory function. Result 1. The clinical memory of epileptic patients including memory quotient, directed memory, associative learning, image free recall, meaningless pattern recognition, and characteristic recall of human image were lower than those of normal control group (p0.01). 2. The quality of life of epileptic patients was lower than that of normal control group (p 0.05). Univariate ANOVA: gender, onset age, course of disease, attack frequency, duration, drug use and memory quotient were not significantly correlated (p0.05). 4. Variance analysis showed that less educated epilepsy patients were more likely to suffer from memory impairment. 5. 5. Multiple regression analysis showed that the influencing factors of memory quotient were quality of life and education level. 6. 6%. The factors influencing the quality of life of epileptic patients were anxiety, education level, course of disease and frequency of incidence. Conclusion 1. Memory impairment in young epileptic patients. 2. The main factors affecting clinical memory of young epileptic patients are quality of life and education level. 3. 3. Anxiety, education level, incidence frequency and course of disease are the influencing factors of quality of life in epileptic patients. Improving the quality of life, especially anxiety, may be valuable in reducing memory impairment in epileptic patients.
【學(xué)位授予單位】：福建醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R742.1

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