發(fā)布時(shí)間：2018-06-21 07:47

  本文選題：血栓通注射液 + 阿司匹林　； 參考：《中國(guó)臨床藥理學(xué)雜志》2017年06期

【摘要】：目的觀察血栓通注射液與阿司匹林治療急性復(fù)發(fā)性腦梗死的臨床療效及其對(duì)血管內(nèi)皮生長(zhǎng)因子(VEGF)血清水平的影響。方法 80例急性復(fù)發(fā)性腦梗死患者分為試驗(yàn)組40例與對(duì)照組40例。在常規(guī)治療的基礎(chǔ)上,對(duì)照組給予阿司匹林100 mg pid,口服;試驗(yàn)組在對(duì)照組的基礎(chǔ)上給予血栓通注射液500mg,每天1次,靜脈滴注,2組均連續(xù)治療14 d。觀察2組患者的臨床療效,比較2組患者的血流動(dòng)力學(xué)指標(biāo)變化情況、血栓調(diào)節(jié)蛋白(TM)、組織纖溶酶原激活物抑制物(PAI)、組織纖溶酶原激活物(t-PA)及D-二聚體(D-dimer)水平及VEGF水平。結(jié)果治療后,試驗(yàn)組總有效率為92.50%(37/40例),對(duì)照組為82.50%(33/40例,P0.05)。治療后,試驗(yàn)組患者全血高切黏度(5.45±0.78)mPa·s,血漿高切黏度(1.87±1.33)mPa·s,對(duì)照組全血高切黏度為(5.91±0.24)mPa·s,血漿高切黏度為(2.20±3.09)mPa·s,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。治療后,試驗(yàn)組TM為(35.36±8.14)ng·mL~(-1),PAI為(0.73±0.30)AU·mL~(-1),t-PA為(1.97±0.18)U·mL~(-1),D-二聚體為(0.42±0.28)mg·L~(-1);對(duì)照組TM為(39.50±10.25)ng·mL~(-1),t-PA為(1.35±0.14)U·mL~(-1),D-二聚體為(0.43±0.24)mg·L~(-1),2組較治療前差異有統(tǒng)計(jì)學(xué)意義(P0.05)。試驗(yàn)組t-PA與對(duì)照組比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。試驗(yàn)組治療3,7,14 d的VEGF水平分別為(320.24±45.63),(436.33±35.84),(398.31±46.60)ng·L~(-1),對(duì)照組分別為(370.41±39.52),(542.72±68.00),(352.72±49.80)ng·L~(-1),2組差異有統(tǒng)計(jì)學(xué)意義(P0.05)。所有患者治療中均未出現(xiàn)藥物不良反應(yīng),安全性良好。結(jié)論血栓通注射液與阿司匹林治療急性復(fù)發(fā)性腦梗死療效顯著,血栓通注射液能夠有效改善患者血清VEGF水平。
[Abstract]:Objective To observe the clinical efficacy of Xueshuantong injection and aspirin in the treatment of acute recurrent cerebral infarction and its effect on the serum level of vascular endothelial growth factor (VEGF). Methods 80 cases of acute recurrent cerebral infarction were divided into 40 cases in the experimental group and 40 cases in the control group. On the basis of routine treatment, the control group was given 100 mg PID of aspirin, On the basis of the control group, the experimental group was given Xueshuantong injection 500mg 1 times a day, intravenous drip, and the 2 groups were treated with 14 d. to observe the clinical efficacy of the 2 groups, compared the hemodynamic indexes of the 2 groups, thrombomodulin (TM), tissue plasminogen activator inhibitor (PAI) and tissue plasminogen activator (t-P A) and D- two polymer (D-dimer) level and VEGF level. Results after treatment, the total effective rate was 92.50% (37/40) and 82.50% (33/40, P0.05) in the control group. After treatment, the high shear viscosity (5.45 + 0.78) mPa s, plasma high shear viscosity (1.87 + 1.33) mPa s, and the high shear viscosity (5.91 + 0.24) of the control group were (5.91 + 0.24) mPa. The viscosity was (2.20 + 3.09) mPa s, and the difference was statistically significant (P0.05). After the treatment, the test group was (35.36 + 8.14) ng. ML~ (-1), PAI was (0.73 + 0.30) AU mL~ (-1), t-PA was (1.97 + 0.18) and 0.42 + 0.28); the control group was (39.50 + 10.25). 24) mg. L~ (-1), the difference between the 2 groups was statistically significant (P0.05). The difference between the experimental group t-PA and the control group was statistically significant (P0.05). The VEGF level of the experimental group was (320.24 + 45.63), (436.33 + 35.84), (398.31 + 46.60) ng. L~ (-1), and the control group (370.41 + 39.52), (542.72 + 68), (352.72 + 49.80) ~ (-1), the difference between the 2 groups was statistically significant (P0.05). All patients had no adverse drug reactions and had good safety. Conclusion Xueshuantong injection and aspirin were effective in the treatment of acute recurrent cerebral infarction, and Xueshuantong injection could effectively improve the level of serum VEGF in patients.
【作者單位】： 麗水市中心醫(yī)院神經(jīng)外科;臺(tái)州市中心醫(yī)院神經(jīng)內(nèi)科;
【基金】：浙江省醫(yī)藥衛(wèi)生科技計(jì)劃基金資助項(xiàng)目(2014KYB312)
【分類號(hào)】：R743.33

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