本文選題：寬心合劑 + 椎基底動(dòng)脈成形術(shù)�。� 參考：《中華中醫(yī)藥學(xué)刊》2017年06期

【摘要】：目的:探討分析寬心合劑對(duì)椎基底動(dòng)脈成形術(shù)后再狹窄的影響。方法:隨機(jī)選取2014年10月—2015年12月來(lái)醫(yī)院行椎基底動(dòng)脈成形術(shù)的患者72例,并隨機(jī)分為觀察組和對(duì)照組,每組36例,術(shù)后給予兩組患者相同的常規(guī)抗血小板治療,觀察組在此基礎(chǔ)上口服寬心合劑,術(shù)后6個(gè)月觀察兩組患者的再狹窄情況。結(jié)果:術(shù)后6個(gè)月后,患者復(fù)查頭CTA或DSA,觀察組有3例發(fā)生再狹窄,而對(duì)照組有7例,觀察組發(fā)生再狹窄的人數(shù)顯著少于對(duì)照組,差異具有統(tǒng)計(jì)學(xué)意義(P0.05),兩組患者經(jīng)治療后,TXB2水平均得到增高,術(shù)后2月最高,但兩組對(duì)比無(wú)明顯差異(P0.05);兩組患者術(shù)后血漿t PA的活性均高于治療前,術(shù)后1月最高,然后逐漸降低,觀察組血漿t PA活性的升高情況較對(duì)照組更加明顯,時(shí)間持續(xù)更長(zhǎng),差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:椎基底動(dòng)脈成形術(shù)患者在常規(guī)抗血小板治療的基礎(chǔ)上服用寬心合劑,能夠有效抑制再狹窄的情況,值得在臨床上推廣應(yīng)用。
[Abstract]:Objective: to investigate the effect of Kuanxin mixture on restenosis after vertebrobasilar arterioplasty. Methods: a total of 72 patients with vertebrobasilar angioplasty from October 2014 to December 2015 were randomly divided into observation group and control group with 36 cases in each group. The two groups were treated with the same routine antiplatelet therapy after operation. On this basis, the observation group took Kuanxin mixture and observed the restenosis in both groups 6 months after operation. Results: after 6 months of operation, 3 cases of restenosis occurred in the observation group and 7 cases in the control group. The number of patients with restenosis in the observation group was significantly lower than that in the control group. The difference was statistically significant (P 0.05). After treatment, the level of TXB2 was increased in both groups, but there was no significant difference between the two groups (P 0.05), the activity of plasma t PA in the two groups was higher than that before treatment, and the highest in 1 month after operation, but there was no significant difference between the two groups. The increase of plasma t-PA activity in the observation group was more obvious than that in the control group, and the time lasted longer. The difference was statistically significant (P 0.05). Conclusion: the patients with vertebrobasilar arterioplasty can effectively inhibit restenosis on the basis of routine antiplatelet therapy, which is worth popularizing in clinic.
【作者單位】： 河北醫(yī)科大學(xué)附屬唐山工人醫(yī)院介入科;
【基金】：河北省中醫(yī)藥管理局科研計(jì)劃項(xiàng)目(2014270)
【分類(lèi)號(hào)】：R743

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