本文選題：神經(jīng)母細(xì)胞瘤 + 白細(xì)胞計(jì)數(shù)　； 參考：《南京醫(yī)科大學(xué)學(xué)報(bào)(自然科學(xué)版)》2017年11期

【摘要】：目的:分析兒童神經(jīng)母細(xì)胞瘤(neuroblastma,NB)化學(xué)治療前血常規(guī)結(jié)果與預(yù)后生存,探索其中能提示和判斷疾病預(yù)后的敏感指標(biāo)。方法:本院初次確診NB的63例患兒,同時(shí)結(jié)合入院化療前首次血常規(guī)結(jié)果中的白細(xì)胞(white blood cell,WBC)、淋巴細(xì)胞絕對值(lymphocyte,LYMPH)、中性粒細(xì)胞絕對值(neutrophilic granulocyte,NEUT)、紅細(xì)胞(red blood cell RBC)、血紅蛋白(hemoglobin,HGB)、血小板(platelet,PLT),并行生存情況隨訪,進(jìn)行Kaplan-Meier生存分析和COX比例風(fēng)險(xiǎn)模型回歸分析。結(jié)果:PLT≤200×109/L患兒總體生存率低于PLT200×109/L患兒(P0.05),RBC≤4.0×1012/L患兒總體生存率低于RBC4.0×1012/L患兒(P0.05),HGB≤110 g/L患兒總體生存率低于HGB110 g/L患兒(P0.05)。而WBC、LYMPH、NEUT對預(yù)后風(fēng)險(xiǎn)評估意義不明顯(P0.05)。K-M生存分析:PLT≤200×109/L、RBC≤4.0×1012/L、HGB≤110 g/L是獨(dú)立評價(jià)NB患兒預(yù)后不良的指標(biāo)(P0.05)。而WBC、LYMPH和NEUT對NB患兒預(yù)后生存的判斷意義不明顯(P0.05)。結(jié)論:血常規(guī)檢測簡便易行,化療前血細(xì)胞分析結(jié)果對NB患兒初步預(yù)后判斷有一定意義,結(jié)合血常規(guī)結(jié)果制定化療方案,對預(yù)后改善有一定意義。
[Abstract]:Objective: to analyze the blood routine results and prognosis of neuroblastma in children before chemotherapeutic therapy, and to explore the sensitive indexes which can indicate and judge the prognosis of children with neuroblastoma. Methods: 63 cases of NB were diagnosed in our hospital for the first time. At the same time, combined with the results of the first blood routine before admission to chemotherapy, the white blood cell count, the absolute value of lymphocytes, neutrophil granulocyte neuter, erythrocyte red blood cell blood, hemoglobulin HGB, platelet platelet-PLTT, were followed up. Kaplan-Meier survival analysis and Cox proportional risk model regression analysis were performed. Results the overall survival rate of children with 1% PLT 鈮，

本文編號：2039527