本文選題：腦卒中 + 丁苯酞　； 參考：《東南大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)》2017年06期

【摘要】：目的:探討重復(fù)經(jīng)顱磁刺激聯(lián)合丁苯酞對腦卒中患者運(yùn)動功能及血清學(xué)指標(biāo)的影響。方法:將167例腦卒中患者隨機(jī)分為觀察組85例和對照組82例。兩組均常規(guī)補(bǔ)液聯(lián)合丁苯酞治療,在此基礎(chǔ)上,觀察組予重復(fù)經(jīng)顱磁刺激治療。分別于治療前和治療后7、14、28 d對患者行美國國立衛(wèi)生研究院卒中量表(NIHSS)評分,并于治療前和治療28 d后測量運(yùn)動誘發(fā)電位(MEP)潛伏期,計(jì)算中樞運(yùn)動傳導(dǎo)時間(CMCT),同時檢測兩組血清NSE、S100B和GFAP水平。結(jié)果:觀察組治療7 d后臨床癥狀明顯改善,對照組治療28 d后癥狀好轉(zhuǎn);治療14、28 d神經(jīng)功能恢復(fù)觀察組優(yōu)于對照組,且治療后28 d有效率和痊愈率觀察組高于對照組;MEP潛伏期和CMCT觀察組均較對照組明顯縮短(P0.05),血清NSE、S100B和GFAP水平觀察組明顯低于對照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:重復(fù)經(jīng)顱磁刺激聯(lián)合丁苯酞治療能明顯促進(jìn)腦卒中患者的運(yùn)動功能恢復(fù),并降低患者血清NSE、S100B和GFAP表達(dá)水平。
[Abstract]:Objective: to investigate the effects of repeated transcranial magnetic stimulation (TMS) combined with butyphthalide on motor function and serological parameters in stroke patients. Methods: 167 stroke patients were randomly divided into observation group (n = 85) and control group (n = 82). Both groups were treated with routine fluid resuscitation combined with butyphthalide. On this basis, the observation group was treated with repetitive transcranial magnetic stimulation. The patients were assessed with NIHSS before and 7 days after treatment, and the latency of motor evoked potential (MEP) was measured before treatment and 28 days after treatment. The central motor conduction time (CMCTT) was calculated and the serum levels of NSES100B and GFAP were measured. Results: the clinical symptoms of the observation group were obviously improved after 7 days of treatment, the symptoms of the control group were improved after 28 days of treatment, the nerve function recovery of the observation group was superior to that of the control group at 14 and 28 days. 28 days after treatment, the effective rate and cure rate in the observation group were significantly higher than those in the control group and the CMCT group. The serum NSES100B and GFAP levels in the observation group were significantly lower than those in the control group (P 0.05). Conclusion: repeated transcranial magnetic stimulation combined with butyphthalide can significantly promote motor function recovery and decrease the expression of NSES100B and GFAP in patients with stroke.
【作者單位】： 四川省醫(yī)學(xué)科學(xué)院·四川省人民醫(yī)院骨科;
【分類號】：R743.3
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本文編號：2027878