本文選題：丘腦底核電刺激術(shù) + 帕金森病��； 參考：《天津醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的探討丘腦底核電刺激術(shù)(subthalamic nucleus stimulation,STN-DBS)治療帕金森病(Parkinson's disease,PD)患者術(shù)后療效及認知功能改變。方法13例帕金森病患者,以術(shù)前癥狀情況作為對比基準(zhǔn)線,記錄患者統(tǒng)一帕金森評定量表(unified Parkinson's disease rating scale,UPDRS)評分和蒙特利爾認知評估量表(Montreal cognitive assessment scale,Mo CA)評分。行雙側(cè)丘腦底核電刺激手術(shù),術(shù)后定期隨訪,記錄術(shù)后1個月(腦深部電刺激系統(tǒng)開機)、3個月、6個月的UPDRS和Mo CA評分,對比分析STN-DBS手術(shù)效果。結(jié)果13例帕金森病患者雙側(cè)STN-DBS術(shù)后1月,腦深部電刺激系統(tǒng)開機,UPDRSII(日常生活活動)評分藥物開/關(guān)期分別改善24.7%和27.5%,UPDRSIII(運動檢查)評分藥物開/關(guān)期分別改善25.8%和21.5%,Mo CA評分改善為㧟0.8%,術(shù)后3月UPDRSII評分藥物開/關(guān)期分別改善32.4%和34.2%,UPDRSIII評分藥物開/關(guān)期分別改善53.1%和47.0%,Mo CA評分改善為1.3%,術(shù)后6月UPDRSII評分藥物開/關(guān)期分別改善40.2%和40.0%,UPDRSIII評分藥物開/關(guān)期分別改善57.4%和47.9%,Mo CA評分改善為0.3%。結(jié)論丘腦底核電刺激術(shù)對于帕金森病患者的日常生活活動和運動癥狀改善有效,對于患者的認知癥狀改善無明顯效果。
[Abstract]:Objective to investigate the effect and cognitive function of subthalamic nucleus stimulation (STN-DBS) in the treatment of Parkinson's disease (PD). Methods Thirteen patients with Parkinson's disease were enrolled in this study. The preoperative symptoms were used as the baseline. The unified Parkinson's disease rating scale (UPD RS) and Montreal cognitive assessment scale (Montreal cognitive assessment scale CAMo) were recorded. Bilateral subthalamic nuclear stimulation was performed and followed up regularly. The UPDRS and Mo CA scores were recorded 1 month after operation (the deep brain stimulation system was switched on, 3 months, 6 months), and the results of STN-DBS operation were compared and analyzed. Results one month after operation, 13 patients with Parkinson's disease underwent bilateral STN-DBS. The opening / closing period of the drug was improved by 24.7% and 27.5%, respectively. The opening / closing period of the drug was improved by 25.8% and 21.5Mo / CA, respectively. The score of UPDRSII was improved to 0.8% 3 months after operation. The opening / closing period of UPDRSIII was improved by 53.1% and that of Mo-Mo by 47.0% by 1.3.The opening / closing period of UPDRSII was improved by 40.2% and that of UPDRSIII was improved by 47.2% and 47.9MoCA by 0.33% respectively at 6 months after operation. Conclusion Subthalamic nuclear stimulation is effective in improving daily life and motor symptoms in patients with Parkinson's disease, but not in cognitive symptoms.
【學(xué)位授予單位】：天津醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R742.5

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