本文選題：丘腦底核電刺激術(shù) + 帕金森病��； 參考：《天津醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的探討丘腦底核電刺激術(shù)(subthalamic nucleus stimulation,STN-DBS)治療帕金森病(Parkinson's disease,PD)患者術(shù)后療效及認(rèn)知功能改變。方法13例帕金森病患者,以術(shù)前癥狀情況作為對(duì)比基準(zhǔn)線,記錄患者統(tǒng)一帕金森評(píng)定量表(unified Parkinson's disease rating scale,UPDRS)評(píng)分和蒙特利爾認(rèn)知評(píng)估量表(Montreal cognitive assessment scale,Mo CA)評(píng)分。行雙側(cè)丘腦底核電刺激手術(shù),術(shù)后定期隨訪,記錄術(shù)后1個(gè)月(腦深部電刺激系統(tǒng)開(kāi)機(jī))、3個(gè)月、6個(gè)月的UPDRS和Mo CA評(píng)分,對(duì)比分析STN-DBS手術(shù)效果。結(jié)果13例帕金森病患者雙側(cè)STN-DBS術(shù)后1月,腦深部電刺激系統(tǒng)開(kāi)機(jī),UPDRSII(日常生活活動(dòng))評(píng)分藥物開(kāi)/關(guān)期分別改善24.7%和27.5%,UPDRSIII(運(yùn)動(dòng)檢查)評(píng)分藥物開(kāi)/關(guān)期分別改善25.8%和21.5%,Mo CA評(píng)分改善為㧟0.8%,術(shù)后3月UPDRSII評(píng)分藥物開(kāi)/關(guān)期分別改善32.4%和34.2%,UPDRSIII評(píng)分藥物開(kāi)/關(guān)期分別改善53.1%和47.0%,Mo CA評(píng)分改善為1.3%,術(shù)后6月UPDRSII評(píng)分藥物開(kāi)/關(guān)期分別改善40.2%和40.0%,UPDRSIII評(píng)分藥物開(kāi)/關(guān)期分別改善57.4%和47.9%,Mo CA評(píng)分改善為0.3%。結(jié)論丘腦底核電刺激術(shù)對(duì)于帕金森病患者的日常生活活動(dòng)和運(yùn)動(dòng)癥狀改善有效,對(duì)于患者的認(rèn)知癥狀改善無(wú)明顯效果。
[Abstract]:Objective to investigate the effect and cognitive function of subthalamic nucleus stimulation (STN-DBS) in the treatment of Parkinson's disease (PD). Methods Thirteen patients with Parkinson's disease were enrolled in this study. The preoperative symptoms were used as the baseline. The unified Parkinson's disease rating scale (UPD RS) and Montreal cognitive assessment scale (Montreal cognitive assessment scale CAMo) were recorded. Bilateral subthalamic nuclear stimulation was performed and followed up regularly. The UPDRS and Mo CA scores were recorded 1 month after operation (the deep brain stimulation system was switched on, 3 months, 6 months), and the results of STN-DBS operation were compared and analyzed. Results one month after operation, 13 patients with Parkinson's disease underwent bilateral STN-DBS. The opening / closing period of the drug was improved by 24.7% and 27.5%, respectively. The opening / closing period of the drug was improved by 25.8% and 21.5Mo / CA, respectively. The score of UPDRSII was improved to 0.8% 3 months after operation. The opening / closing period of UPDRSIII was improved by 53.1% and that of Mo-Mo by 47.0% by 1.3.The opening / closing period of UPDRSII was improved by 40.2% and that of UPDRSIII was improved by 47.2% and 47.9MoCA by 0.33% respectively at 6 months after operation. Conclusion Subthalamic nuclear stimulation is effective in improving daily life and motor symptoms in patients with Parkinson's disease, but not in cognitive symptoms.
【學(xué)位授予單位】：天津醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R742.5

【參考文獻(xiàn)】

相關(guān)期刊論文 前6條

1 凌至培;許百男;;術(shù)中核磁共振引導(dǎo)下DBS植入治療帕金森病[J];軍醫(yī)進(jìn)修學(xué)院學(xué)報(bào);2012年08期

2 中國(guó)帕金森病腦深部電刺激療法專(zhuān)家組;;中國(guó)帕金森病腦深部電刺激療法專(zhuān)家共識(shí)[J];中華神經(jīng)外科雜志;2012年08期

3 李建國(guó);陳寶友;武慧麗;商崇智;梁晉;趙永青;董月青;;微電極引導(dǎo)立體定向核團(tuán)毀損和腦深部電刺激治療帕金森病[J];立體定向和功能性神經(jīng)外科雜志;2010年01期

4 張世忠;張旺明;徐強(qiáng);徐如祥;;微電極導(dǎo)向核團(tuán)毀損術(shù)和腦深部電刺激術(shù)治療帕金森病的療效分析[J];中華神經(jīng)外科雜志;2006年12期

5 張世忠,徐強(qiáng),徐如祥,張旺明,李鐵林;腦深部刺激電極埋置術(shù)治療帕金森病療效研究[J];中國(guó)神經(jīng)精神疾病雜志;2003年06期

6 劉宗惠;腦立體定向技術(shù)臨床應(yīng)用新進(jìn)展[J];中華神經(jīng)外科疾病研究雜志;2003年01期

相關(guān)重要報(bào)紙文章 前1條

1 戴岱;;遠(yuǎn)離帕金森病 拒絕生命震顫[N];中國(guó)消費(fèi)者報(bào);2013年

，

本文編號(hào)：2022327