本文選題：血管性癡呆 + MRI　； 參考：《寧夏醫(yī)科大學(xué)》2014年碩士論文

【摘要】：目的本研究旨在通過(guò)分析缺血性卒中血管性癡呆的頭顱MRI特點(diǎn)及相關(guān)危險(xiǎn)因素，探討其與VD發(fā)病的關(guān)系。 方法篩選2012年1月—2013年7月在寧夏回族自治區(qū)人民醫(yī)院神經(jīng)內(nèi)科住院的腦梗死后VD患者51例為VD組，診斷符合2002年中華醫(yī)學(xué)會(huì)神經(jīng)病學(xué)分會(huì)血管性癡呆診斷標(biāo)準(zhǔn)。同期選擇腦梗死后非VD患者48例為非VD組(對(duì)照組)。99例腦卒中患者均于卒中后3個(gè)月內(nèi)采用簡(jiǎn)易精神量表(MMSE)、HIS量表和蒙特利爾認(rèn)知評(píng)估量表(MoCA)對(duì)其進(jìn)行認(rèn)知功能評(píng)定。比較分析VD組和非VD組患者的頭顱MRI特點(diǎn)及相關(guān)危險(xiǎn)因素。 結(jié)果 1.VD組中額葉皮層的梗死發(fā)生率明顯高于非VD組(X2=6.10，P0.05)；VD組中皮層下額葉的梗死發(fā)生率明顯高于非VD組(X2=4.45，，P0.05)；VD組中內(nèi)囊的梗死發(fā)生率明顯高于非VD組(X2=3.96，P0.05)；VD組中丘腦的梗死發(fā)生率明顯高于非VD組(X2=4.78，P0.05)。 2.VD組大梗死發(fā)生率明顯高于非VD組(X2=9.11，P0.05)；VD組中梗死發(fā)生率明顯高于非VD組(X2=5.58，P0.05)。 3.VD組吸煙發(fā)生率明顯高于非VD組(X2=12.41，P0.05)；VD組高血壓發(fā)生率明顯高于非VD組(X2=4.50，P0.05)；VD組糖尿病發(fā)生率明顯高于非VD組(X2=5.619,P0.05)。經(jīng)多因素回歸分析進(jìn)一步分析發(fā)現(xiàn)吸煙、高血壓、糖尿病與VD的發(fā)生相關(guān)。 4.VD組年齡、冠心病、高脂血癥與非VD組相比，差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。 結(jié)論 1.額葉皮層、皮層下額葉、內(nèi)囊和丘腦的梗死更易導(dǎo)致VD的發(fā)生。 2.大梗死、中梗死比腔隙性梗死易導(dǎo)致VD發(fā)生。 3.吸煙、高血壓、糖尿病與VD的發(fā)生相關(guān)，年齡、冠心病、高脂血癥與VD發(fā)生的關(guān)系不明顯。
[Abstract]:Objective to investigate the relationship between cerebral MRI features and related risk factors of ischemic stroke vascular dementia (VD). Methods from January 2012 to July 2013, 51 patients with VD after cerebral infarction in Department of Neurology, people's Hospital of Ningxia Hui Autonomous region were selected as VD group. The diagnosis was in accordance with the diagnostic criteria of vascular dementia in the Neurology Branch of the Chinese Medical Association in 2002. At the same time, 48 patients with non-VD after cerebral infarction were selected as non-VD group (control group, n = 99). The cognitive function was evaluated by MMSE / his scale and Montreal Cognitive Assessment scale (MoCA) within 3 months after stroke. The cranial MRI features and related risk factors of VD and non-VD patients were compared and analyzed. Results 1. The incidence of infarct in frontal cortex in VD group was significantly higher than that in non-VD group (X _ 2X _ (6.10) P _ (0.05) P _ (0.05) and non-VD group (P _ (4.45) P _ (0.05) and the incidence of infarction in internal capsule in VD group was significantly higher than that in non-VD group (X _ 23.96 P _ 0.05). The incidence of thalamus infarction in VD group was significantly higher than that in non-VD group (P 0.05). 2. The incidence of large infarction in VD group was significantly higher than that in non-VD group (X29.11) P0.05 (P 0.05). 3. The incidence of smoking in VD group was significantly higher than that in non-VD group (P 0.05). The incidence of hypertension in VD group was higher than that in non-VD group. Multivariate regression analysis showed that smoking, hypertension and diabetes were correlated with VD. 4. There was no significant difference in age, coronary heart disease, hyperlipidemia and non-VD between VD group and non-VD group (P 0.05). Conclusion 1. The infarction of frontal cortex, subcortical frontal lobe, internal capsule and thalamus is more likely to cause VD. 2. 2. Large infarction, middle infarction is more likely to lead to VD than lacunar infarction. 3. 3. Smoking, hypertension and diabetes were associated with VD. Age, coronary heart disease, hyperlipidemia were not associated with VD.
【學(xué)位授予單位】：寧夏醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類(lèi)號(hào)】：R743.3

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