本文選題：帕金森病 + T淋巴細(xì)胞��； 參考：《新疆醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:研究新疆地區(qū)帕金森病(PD)患者外周血中淋巴細(xì)胞亞群及NK細(xì)胞數(shù)量的變化,為PD發(fā)病機(jī)制研究提供新的視角。方法:應(yīng)用流式細(xì)胞儀熒光染色法測(cè)定33例維吾爾族及漢族PD患者外周血中T淋巴細(xì)胞,B淋巴細(xì)胞,NK細(xì)胞數(shù)量,并與20例健康對(duì)照組進(jìn)行比較。同時(shí)分析不同民族間,不同用藥,不同病程及疾病嚴(yán)重程度與各細(xì)胞亞群變化的相關(guān)性。結(jié)果:帕金森病患者外周血中CD3+,CD4+,CD8+T淋巴細(xì)胞較對(duì)照組明顯下降,但B淋巴細(xì)胞較對(duì)照組無明顯變化,NK細(xì)胞較對(duì)照組上升。維族患者與漢族患者相比,各淋巴細(xì)胞亞群及NK細(xì)胞數(shù)量無明顯變化。采用L-多巴胺或鹽酸普拉克索治療患者各細(xì)胞亞群無明顯改變,CD3+T淋巴細(xì)胞亞群與PD患者年齡、B細(xì)胞亞群與PD患者病程相關(guān)。結(jié)論:PD患者外周血的淋巴細(xì)胞及NK細(xì)胞比例失調(diào),但維漢民族之間無明顯差異。外周血T、B淋巴細(xì)胞亞群的變化可能有助于評(píng)估PD的病情進(jìn)展。
[Abstract]:Aim: to study the changes of lymphocyte subsets and NK cells in peripheral blood of PD patients in Xinjiang area, and to provide a new perspective for the pathogenesis of PD. Methods: the number of T lymphocyte B lymphocytes and NK cells in peripheral blood of 33 PD patients of Uygur and Han nationality were determined by flow cytometry fluorescence staining and compared with 20 healthy controls. At the same time, the correlation between different nationalities, different drug use, different course of disease and severity of disease with the change of cell subsets was analyzed. Results: the CD3 T lymphocytes in peripheral blood of Parkinson's disease patients were significantly lower than those in the control group, but the B lymphocytes had no significant change compared with the control group, and the NK cells were higher than those in the control group. The number of lymphocyte subsets and NK cells in Uygur patients was not significantly different from that in Han patients. There was no significant change of CD3 T lymphocyte subsets in patients treated with L- dopamine or Praquisol hydrochloride and age B cell subsets were correlated with the course of disease in PD patients. Conclusion the proportion of lymphocytes and NK cells in the peripheral blood of the patients with 10% PD is disordered, but there is no significant difference between the Uygur and Han nationalities. The changes of T B lymphocyte subsets in peripheral blood may be helpful to assess the progression of PD.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R742.5

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本文編號(hào)：2019457