本文選題：癲癇 + 腦電描記術(shù)��； 參考：《安徽醫(yī)科大學(xué)》2015年碩士論文

【摘要】：目的共情能力和情緒加工作為社會認(rèn)知神經(jīng)科學(xué)的重要組成部分,在人類社會交往和人際活動中扮演重要角色,對其研究有助于理解在復(fù)雜多變的環(huán)境下人腦的活動機制。當(dāng)前有關(guān)癲癇的認(rèn)知神經(jīng)心理學(xué)研究表明,癲癇患者不僅在非社會認(rèn)知成分如記憶、注意、執(zhí)行功能等方面受損,同時社會認(rèn)知作為獨立的認(rèn)知成分也愈發(fā)受到關(guān)注,癲癇患者的社會功能降低已成為影響其生活質(zhì)量的重要因素,同時有研究認(rèn)為額葉與社會認(rèn)知密切相關(guān)。本研究一方面通過對癲癇患者共情和情緒識別能力的評估,研究癲癇患者是否存在以上認(rèn)知障礙,另一方面探討造成改變的可能相關(guān)影響因素,并進一步明確額葉與社會認(rèn)知的關(guān)系。方法經(jīng)神經(jīng)心理學(xué)背景測試篩查后采用人際反應(yīng)指針量表、眼區(qū)基本和復(fù)雜情緒識別任務(wù),分別對62例動態(tài)腦電監(jiān)測示不同腦區(qū)癇樣放電的癲癇患者與80例健康對照者進行情緒識別和共情能力的評估和比較。結(jié)果癲癇病人組共情總分、認(rèn)知共情、觀點采擇、想象得分均顯著低于健康對照組(分別46.39±9.74、50.99±9.97,t=-2.893,P=0.004;23.31±7.10、27.24±6.22,t=-3.974,P=0.000;10.18±4.21、11.84±3.67,t=-2.838,P=0.005;13.13±4.46、15.40±3.84,t=-3.698,P=0.000)差異具有統(tǒng)計學(xué)意義;而情感共情、同情關(guān)心、個人痛苦得分與對照組相比差異均無統(tǒng)計學(xué)意義(P0.05)。額葉癇樣放電組在共情總分、認(rèn)知共情、觀點采擇得分上分別與額葉以外腦區(qū)癇樣放電組、腦電圖無異常的癲癇病人組、健康對照組相比差異都有統(tǒng)計學(xué)意義(P0.05),而情感共情、同情關(guān)心、個人痛苦得分在四組間差異尚不顯著(P0.05)。共情得分與其他神經(jīng)心理學(xué)背景測試無相關(guān)性。在眼區(qū)情緒識別得分上,癲癇組在六種眼區(qū)基本情緒識別正確數(shù)、總情緒識別正確數(shù)及眼區(qū)復(fù)雜情緒識別正確數(shù)[分別喜(19.3±2.0)分、怒(17.9±2.0)分、悲(18.1±2.3)分、恐(16.4±1.9)分、厭(17.6±2.1)分、驚(18.3±1.5)分、總基本情緒(107.7±8.1)分、復(fù)雜情緒(23.3±4.2)分]上均顯著低于健康對照組[分別喜(19.9±0.2)分、怒(18.9±1.0)分、悲(19.2±1.0)分、恐(17.6±1.3)分、厭(18.6±1.2)分、驚(19.1±1.1)分、總基本情緒(113.4±3.4)分、復(fù)雜情緒(27.1±2.8)分],差異均有統(tǒng)計學(xué)意義(均P0.05);在男女性別判斷任務(wù)上與健康對照組差異無統(tǒng)計學(xué)意義(P0.05)。癲癇組眼區(qū)基本情緒與眼區(qū)復(fù)雜情緒識別正相關(guān)(r=r=0.716,P=0.000)。癲癇組共情總分與眼區(qū)復(fù)雜情緒識別正相關(guān)(r=0.261,P=0.043)。結(jié)論癲癇病人存在分離性的共情障礙,認(rèn)知共情損傷而情感共情保留,支持共情的兩成分模型,認(rèn)知共情和情感共情是可相互分離的兩種成分�；颊叩墓睬槟芰颓榫w識別所反映的心理理論能力存在關(guān)聯(lián)。額葉癇樣放電所致的額葉功能缺陷可能是影響癲癇患者社會認(rèn)知的關(guān)鍵因素之一。
[Abstract]:Objective as an important part of social cognitive neuroscience, empathy and emotional processing play an important role in human social interaction and interpersonal activities. Current cognitive neuropsychological studies on epilepsy show that epileptic patients are not only impaired in non-social cognitive components such as memory, attention and executive function, but also increasingly concerned about social cognition as an independent cognitive component. The reduction of social function has become an important factor affecting the quality of life of epileptic patients, and it is believed that frontal lobe is closely related to social cognition. On the one hand, by evaluating the ability of empathy and emotion recognition in epileptic patients, we study whether the above cognitive impairment exists in epileptic patients, on the other hand, we discuss the possible related factors that cause the changes. The relationship between frontal lobe and social cognition was further clarified. Methods after neuropsychological background screening, interpersonal reaction pointer scale was used to identify basic and complex emotion in eye area. The emotional recognition and empathy ability of 62 epileptiform discharges in different brain regions and 80 healthy controls were evaluated and compared. Results the scores of total empathy, cognitive empathy, viewpoint selection and imagination in epileptic patients group were significantly lower than those in the healthy control group (46.39 鹵9.74g / 50.99 鹵9.97t ~ (-2.893) P 0.004t ~ (-2.893) P 0.004 ~ 23.31 鹵7.1022 ~ 27.24 鹵6.22 ~ t ~ (-3.974) P 0.00010.18 鹵3.671 ~ (11.84) 鹵3.637 ~ (th) P 0.00513.13 鹵4.4615.40 鹵3.84t ~ (-3.698t) P ~ (0.000), and the difference was statistically significant between the two groups. There was no significant difference in individual pain score between the two groups (P 0.05). There were significant differences in the total score, cognitive empathy, and point of view between the frontal lobe epileptiform discharge group and the frontal lobe epileptiform discharge group, the epileptic patients with no abnormal EEG, and the healthy control group (P 0.05). There was no significant difference in the score of personal pain between the four groups (P 0.05). There was no correlation between empathy score and other neuropsychological background tests. In the Epilepsy group, the correct number of basic emotion recognition, the total correct number of emotion recognition and the correct number of complex emotion recognition of eye region in six kinds of eye regions were correct [19.3 鹵2.0), 17.9 鹵2.0), 18.1 鹵2.3), 16.4 鹵1.9), 17.6 鹵2.1), 18.3 鹵1.5) in Epilepsy group, respectively. The scores of total basic emotion (107.7 鹵8.1), complex emotion (23.3 鹵4.2) were significantly lower than those of the healthy control group [19.9 鹵0.2), 18.9 鹵1.0), 19.2 鹵1.0), 17.6 鹵1.3), 18.6 鹵1.2), 19.1 鹵1.1), 113.4 鹵3.4 鹵3.4), respectively. The scores of complex emotions were 27.1 鹵2.8), the differences were statistically significant (all P 0.05), and there was no significant difference between male and female in sex judgment task compared with the healthy control group (P 0.05). There was a positive correlation between the basic emotion of eye area and complex emotion recognition in epileptic group. The total score of empathy in epileptic group was positively correlated with complex emotion recognition in eye area. Conclusion Epilepsy patients have separate empathy disorder. Cognitive empathy injury and emotional empathy retention support the two component model of empathy. Cognitive empathy and emotional empathy are two kinds of components that can be separated from each other. There is a correlation between the empathy ability of patients and the psychological theory ability reflected by emotion recognition. Frontal lobe dysfunction caused by epileptiform discharge may be one of the key factors affecting social cognition of epileptic patients.
【學(xué)位授予單位】：安徽醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R742.1

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