本文選題：依達拉奉 + 奧扎格雷��； 參考：《中國老年學(xué)雜志》2017年12期

【摘要】：目的探討依達拉奉聯(lián)合奧扎格雷對急性腦梗死患者腦血流指標以及頸動脈粥樣斑塊的影響。方法急性腦梗死患者120例,根據(jù)隨機數(shù)字表分為對照組和觀察組各60例。對照組給予疏血通,依達拉奉、瑞舒伐他汀鈣、阿司匹林進行治療,觀察組在對照組基礎(chǔ)上給予奧扎格雷進行治療。評估兩組臨床療效、神經(jīng)功能缺損、日常生活能力、腦血流指標以及頸動脈粥樣斑塊等指標。結(jié)果觀察組總有效率顯著高于對照組(χ2=8.010,P0.05)。治療后,觀察組美國國立衛(wèi)生研究院卒中量表(NIHSS)評分顯著低于對照組,日常生活能力量表指數(shù)(BI)顯著高于對照組(均P0.05)。治療后觀察組收縮期血流速度(Vs)、平均血流速度(Vm)顯著高于對照組,阻力指數(shù)(RI)和脈動指數(shù)(PI)均顯著低于對照組(均P0.05)。治療后觀察組頸動脈內(nèi)膜中層厚度和斑塊面積均顯著低于對照組(P0.05)。結(jié)論依達拉奉和奧扎格雷聯(lián)合應(yīng)用能夠恢復(fù)腦組織血液循環(huán),減小頸動脈粥樣斑塊,顯著提高臨床對急性腦梗死的治療效果,具有較高的臨床應(yīng)用價值。
[Abstract]:Objective to investigate the effects of Edaravone combined with ozagrel on cerebral blood flow and carotid atherosclerotic plaque in patients with acute cerebral infarction. Methods 120 patients with acute cerebral infarction were randomly divided into control group (n = 60) and observation group (n = 60). The control group was treated with Shuxuetong, Edaravone, rosuvastatin calcium and aspirin, and the observation group was treated with ozagrel on the basis of the control group. The clinical efficacy, neurological deficit, ADL, cerebral blood flow and carotid atherosclerotic plaque were evaluated. Results the total effective rate in the observation group was significantly higher than that in the control group (蠂 ~ 2 = 8.010, P 0.05). After treatment, the NIHSS score of the National Institutes of Health in the observation group was significantly lower than that in the control group, and the activity of daily living (ADL) index was significantly higher in the observation group than in the control group (all P 0.05). After treatment, the systolic blood flow velocity and mean blood flow velocity in the observation group were significantly higher than those in the control group, and the resistance index (RI) and pulsatile index (Pi) were significantly lower than those in the control group (all P 0.05). After treatment, the carotid intima-media thickness and plaque area in the observation group were significantly lower than those in the control group (P 0.05). Conclusion the combination of Edaravone and ozagrel can restore blood circulation of brain tissue, reduce carotid atherosclerotic plaque, and improve the clinical therapeutic effect of acute cerebral infarction.
【作者單位】： 濰坊市腦科醫(yī)院;淄博市中心醫(yī)院ICU;
【分類號】：R743.33

【參考文獻】

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本文編號：1981276