本文選題：腦梗死 + 腦出血��； 參考：《中國(guó)繼續(xù)醫(yī)學(xué)教育》2016年32期

【摘要】：目的研究急性腦梗死、腦出血患者發(fā)病早期腸道屏障功能隨病程進(jìn)展的變化。方法選取2013年9月~2015年12月徐州市中心醫(yī)院神經(jīng)內(nèi)科,并確診為急性腦梗死、腦出血的患者67例,分別于不同時(shí)間點(diǎn)取靜脈血(12 h內(nèi)、24 h、72 h、1周、3個(gè)月)。同時(shí)選取同期門(mén)診健康體檢者54例作為對(duì)照組,檢測(cè)其血漿D-乳酸(D-LAC)、二胺氧化酶(DAO)水平。結(jié)果 (1)與正常對(duì)照組相比,急性腦梗死、腦出血患者在發(fā)病后均出現(xiàn)腸黏膜屏障功能改變,且腦梗死、腦出血組患者在發(fā)病24h后較發(fā)病初期(12 h內(nèi))D-LAC、DAO水平逐漸升高,72 h達(dá)到高峰,隨后1周血清D-LAC及DAO持續(xù)高水平(P0.05);(2)在發(fā)病12 h內(nèi)、24 h、72 h、1周、3個(gè)月5個(gè)時(shí)間段內(nèi)腦梗死、腦出血患者兩組間的D-LAC、DAO水平對(duì)比,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論腦梗死及腦出血患者急性期應(yīng)激狀態(tài)下均會(huì)出現(xiàn)腸黏膜屏障功能的改變,且兩者在相同發(fā)病時(shí)間段內(nèi)無(wú)顯著差異。
[Abstract]:Objective to study the changes of intestinal barrier function in patients with acute cerebral infarction and cerebral hemorrhage. Methods 67 patients with acute cerebral infarction and intracerebral hemorrhage were selected from Department of Neurology, Xuzhou Central Hospital from September 2013 to December 2015. Venous blood samples were collected at different time points within 12 h, 24 h, 72 h, 1 week, 3 months. The plasma levels of D-LACU and diamine oxidase (DAO) were measured in 54 healthy persons in the same period as control group. Results 1) compared with the normal control group, the patients with acute cerebral infarction and cerebral hemorrhage all showed changes of intestinal mucosal barrier function and cerebral infarction after the onset of acute cerebral infarction and cerebral hemorrhage. In the ICH group, the level of D-LACN Dao increased gradually within 12 hours after the onset of ICH and reached its peak at 72 hours after the onset. The serum levels of D-LAC and DAO continued to be high at 1 week after the onset of ICH. The serum levels of D-LAC and DAO were maintained at a high level (P0.05) within 12 hours after the onset of ICH, and within 24 hours and 72 hours after the onset of ICH, and within 5 periods of 3 months, the cerebral infarction occurred within 5 periods of 3 months. There was no significant difference in D-LACU Dao level between the two groups (P 0. 05). Conclusion the changes of intestinal mucosal barrier function in patients with cerebral infarction and intracerebral hemorrhage in acute stress state were observed, and there was no significant difference between the two groups in the same period of onset.
【作者單位】： 徐州市中心醫(yī)院神經(jīng)內(nèi)科;徐州醫(yī)學(xué)院附屬醫(yī)院神經(jīng)內(nèi)科;徐州市中心醫(yī)院胃腸外科;
【分類(lèi)號(hào)】：R743.3

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