本文選題：尤瑞克林 + 急性腦梗死　； 參考：《河北醫(yī)科大學》2017年碩士論文

【摘要】：目的:越來越多的證據(jù)顯示,注射用尤瑞克林可以通過改善腦梗死區(qū)域的血液灌注從而使病人獲益,該藥物可以舒張血管、促進血管再生,本實驗旨在探討該藥物對于人體內(nèi)炎癥因子的調(diào)節(jié)作用,并研究該藥物對神經(jīng)功能缺損的療效。方法:本實驗共收集74名就診于河北醫(yī)科大學第二醫(yī)院的首次發(fā)病的腦梗死患者,依據(jù)是否應用注射用尤瑞克林,分為:對照組、尤瑞克林組。其中,對照組共30人,給予神經(jīng)內(nèi)科基礎(chǔ)治療,尤瑞克林組共44人,在基礎(chǔ)治療之上加用注射用尤瑞克林靜脈滴注。通過監(jiān)測血清中白細胞介素-6(interleukin-6,IL-6)和腫瘤壞死因子(tumor necrosis factor alpha,TNF-α)的濃度變化,記錄美國國立衛(wèi)生研究院卒中量表(the National Institutes of Health Stroke Scale,NIHSS)和簡明精神狀態(tài)量表(the MiniMental State Examination,MMSE)的評分變化,來探究該藥物的作用,以利于指導臨床用藥。結(jié)果:依據(jù)是否應用注射用尤瑞克林,將74名患者分為:對照組、尤瑞克林組,可以觀察到:用藥10天后,與對照組相比,尤瑞克林組的IL-6、TNF-α降低程度更大,NIHSS評分改善程度更大。另外,依據(jù)入院MMSE評分,可將上述74名患者重新分為:認知缺損組、無認知缺損組,可以觀察到:認知缺損組的IL-6呈下降趨勢,而無認知缺損組的IL-6呈上升趨勢。結(jié)論:注射用尤瑞克林能夠降低IL-6、TNF-α,改善神經(jīng)功能缺損,該藥物能夠通過降低急性期腦梗死的炎癥反應來使患者獲益。另外,炎癥因子IL-6可能在認知缺損的發(fā)生、發(fā)展過程中扮演了重要角色。
[Abstract]:Objective: there is growing evidence that eucrine for injection benefits patients by improving blood perfusion in the infarcted area, and that the drug relaxes blood vessels and promotes vascular regeneration. The aim of this study was to investigate the regulatory effect of the drug on inflammatory factors in human body and to study the effect of the drug on neurological impairment. Methods: a total of 74 patients with cerebral infarction who were first diagnosed in the second Hospital of Hebei Medical University were selected and divided into control group and eurekline group according to whether or not to use eurekline for injection. 30 patients in the control group were treated with basic neurology, 44 patients in the Urekline group were treated with intravenous drip of Urekline for injection in addition to the basic treatment. The changes of serum levels of interleukin-6 (IL-6) and tumor necrosis factor alpha-TNF- 偽 (TNF- 偽) were measured to record the changes of the National Institutes of Health Stroke scale (NIHSS) and the MiniMental State scale of mental state (MMSE) in the National Institutes of Health (NIH). To explore the role of the drug in order to guide clinical use. Results: 74 patients were divided into control group and eurexine group according to whether or not they were used for injection. It was observed that IL-6 TNF- 偽 decreased more significantly than that of control group after 10 days of medication, and the improvement of NIHSS score was greater. In addition, according to the MMSE score of admission, the above 74 patients can be re-divided into cognitive defect group, no cognitive defect group, it can be observed that the IL-6 of cognitive defect group showed a downward trend, but no cognitive defect group IL-6 showed an upward trend. Conclusion: Urethrin for injection can reduce IL-6 TNF- 偽 and improve nerve function defect. This drug can benefit patients by reducing inflammatory reaction of acute cerebral infarction. In addition, inflammatory factor IL-6 may play an important role in the occurrence and development of cognitive impairment.
【學位授予單位】：河北醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R743.3

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