本文選題：垂體腺瘤 + 經(jīng)蝶竇入路�。� 參考：《福建醫(yī)科大學(xué)》2014年碩士論文

【摘要】：【目的】探討經(jīng)單鼻孔-蝶竇入路垂體腺瘤術(shù)后尿崩癥的影響因素及治療。 【方法】對2008年12月至2012年12月在我科接受經(jīng)單鼻孔-蝶竇入路垂體腺瘤切除術(shù)病人的臨床資料進(jìn)行回顧性分析。統(tǒng)計(jì)其性別、年齡、病程、腫瘤大小、生長方向、腫瘤切除程度、內(nèi)分泌功能分型等因素，應(yīng)用t檢驗(yàn)、χ2檢驗(yàn)等方法進(jìn)行分析，判定術(shù)后尿崩癥的影響因素。 【結(jié)果】符合本組研究的手術(shù)275例，術(shù)后24小時(shí)內(nèi)結(jié)果不納入統(tǒng)計(jì)，發(fā)生尿崩癥96例（34.9%），其中暫時(shí)型93例，三相型2例，永久型1例。統(tǒng)計(jì)顯示術(shù)后尿崩癥的發(fā)生與腫瘤大小、生長方向及切除程度相關(guān)(P0.05),而與性別、年齡、病程及內(nèi)分泌功能分型無關(guān)(P0.05)。其中微腺瘤和巨大腺瘤術(shù)后尿崩癥發(fā)生率均高于大腺瘤(P0.0167),鞍上生長的垂體腺瘤術(shù)后尿崩癥發(fā)生率顯著高于其它生長方向(P=0.000),垂體腺瘤全切除術(shù)后尿崩癥發(fā)生率高于大部分切除(P0.0167)。 【結(jié)論】掌握尿崩癥發(fā)生的相關(guān)因素，提高手術(shù)技巧，，術(shù)中注意保護(hù)殘余垂體，術(shù)后及時(shí)診斷和正確治療是防治垂體腺瘤術(shù)后尿崩癥的關(guān)鍵。
[Abstract]:Objective: to investigate the influencing factors and treatment of diabetes insipidus after pituitary adenoma operation via single nostril-sphenoid sinus approach. [methods] the clinical data of patients undergoing transsphenoidal pituitary adenoma resection from December 2008 to December 2012 in our department were retrospectively analyzed. Sex, age, course of disease, tumor size, growth direction, tumor excision degree, endocrine function type and other factors were analyzed by means of t test and 蠂 2 test to determine the influencing factors of diabetes insipidus after operation. [results] in 275 cases, the results were not included in the statistics within 24 hours after operation. There were 96 cases of diabetes insipidus, including 93 cases of temporary type, 2 cases of three-phase type and 1 case of permanent type. Statistics showed that the incidence of diabetes insipidus was correlated with tumor size, growth direction and excision degree, but not with sex, age, course of disease and endocrine function classification. The incidence of diabetes insipidus after operation of microadenoma and giant adenoma was higher than that of macroadenoma (P0.0167), the incidence of postoperative diabetes insipidus of pituitary adenoma growing in suprasellar was significantly higher than that of other growth direction (P0. 000), and the incidence of diabetes insipidus after total resection of pituitary adenoma was higher than that after resection of pituitary adenoma (P0. 0167). [conclusion] mastering the related factors of diabetes insipidus, improving operative skills, protecting residual pituitary gland during operation, timely diagnosis and correct treatment after operation are the key to prevent and cure diabetes insipidus after operation.
【學(xué)位授予單位】：福建醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R739.41


本文編號：1969305