本文選題：電刺激 + H-H模型��； 參考：《北京交通大學》2014年碩士論文

【摘要】：神經(jīng)纖維通過電活動調(diào)節(jié)人體機能,而臨床中,神經(jīng)纖維異常興奮會造成許多功能障礙疾病,研究神經(jīng)纖維的興奮傳導規(guī)律,阻斷不必要的神經(jīng)興奮,可以恢復某些受損神經(jīng)的正常功能。因此,尋找適合的電刺激方法,研究神經(jīng)纖維傳導阻斷的作用機制和影響因素具有重要的臨床意義,可作為治療手段治愈某些功能障礙疾病。學者們通過對神經(jīng)纖維的大量研究,建立了許多數(shù)學模型進行電刺激下神經(jīng)傳纖維導阻斷的仿真研究,并揭示了神經(jīng)纖維電活動的某些復雜現(xiàn)象。通過神經(jīng)模型進行研究已經(jīng)成為神經(jīng)纖維電位變化研究的最有效方法。 本文以無髓神經(jīng)纖維為研究對象,基于無髓神經(jīng)纖維的Hodgkin-Huxley (H-H)模型,研究了在高頻雙向電刺激下無髓神經(jīng)纖維的阻斷閾、影響因素和阻斷機制,并提出電刺激結束后軸突恢復刺激前初始狀態(tài)的恢復時間測量以及恢復機制。本文的主要工作有： 1)建立了基于H-H模型的無髓神經(jīng)傳導阻斷系統(tǒng),在高頻雙向電流刺激下得出不同直徑神經(jīng)纖維的阻斷閾,并確定最小阻斷頻率為5kHz； 2)研究了無髓神經(jīng)模型產(chǎn)生傳導阻斷的作用機制,即鉀離子通道的激活,使其產(chǎn)生傳導阻斷現(xiàn)象。確定了溫度和電極.神經(jīng)纖維距離對阻斷閾的影響； 3)對電刺激的開始和結束后神經(jīng)纖維的狀態(tài)進行了全面研究； 4)針對電刺激結束后神經(jīng)纖維恢復刺激前的初始狀態(tài)進行了創(chuàng)新的研究。確定不同直徑神經(jīng)纖維的恢復時間,以及離子通道和鈉.鉀泵的作用機制。
[Abstract]:Nerve fibers regulate the function of human body by electrical activity. In clinic, abnormal stimulation of nerve fibers can cause many diseases of dysfunction, so the regulation of excitatory conduction of nerve fibers is studied, and unnecessary nerve excitations are blocked. It can restore the normal function of some damaged nerves. Therefore, it is of great clinical significance to find suitable electrical stimulation methods and to study the mechanism and influencing factors of nerve fiber conduction blockade, which can be used as a therapeutic method to cure some dysfunctional diseases. Through a large number of researches on nerve fibers, many mathematical models have been established to simulate the blocking of nerve fiber conductance under electrical stimulation, and some complex phenomena of nerve fiber electrical activity have been revealed. The study of neural model has become the most effective method to study the changes of nerve fiber potential. In this paper, the unmyelinated nerve fibers were used as the research object, and based on the Hodgkin-Huxley H-H model of unmyelinated nerve fibers, the blocking threshold, influencing factors and blocking mechanism of unmyelinated nerve fibers under high frequency bidirectional electrical stimulation were studied. The recovery time and mechanism of the initial state before the axon recovery were proposed. The main work of this paper is as follows: 1) an unmyelinated nerve conduction blocking system based on H-H model was established. Under the stimulation of high frequency bidirectional current, the blocking threshold of nerve fibers with different diameters was obtained, and the minimum blocking frequency was determined to be 5 kHz; 2) to study the mechanism of conduction blocking in unmyelinated neural model, that is, the activation of potassium channel. The temperature and electrode are determined. The effect of nerve fiber distance on blocking threshold; 3) the state of nerve fibers at the beginning and the end of electrical stimulation was studied. 4) an innovative study was carried out on the initial state of nerve fibers before stimulation after the end of electrical stimulation. Determine the recovery time of nerve fibers with different diameters, as well as ion channels and sodium. Mechanism of action of potassium pump.
【學位授予單位】：北京交通大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R741

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本文編號：1967774