本文選題：急性腦梗死 + 和肽素�。� 參考：《中國實(shí)驗(yàn)診斷學(xué)》2016年03期

【摘要】：目的觀察急性腦梗死患者血清和肽素、NT-proBNP水平變化情況,探討兩者與急性腦梗死病情的關(guān)系及其臨床意義。方法選擇我院神經(jīng)內(nèi)科92例急性腦梗死患者作為研究對(duì)象,同期來醫(yī)院參加體檢的90例健康人作為對(duì)照組,分別收集他們的一般資料,測(cè)定其血清和肽素、NT-proBNP含量,比較兩組研究對(duì)象及不同病情急性腦梗死患者血清和肽素、NT-proBNP水平變化的差異。結(jié)果急性腦梗死輕癥組、重癥組患者的血清和肽素和NT-proBNP水平高于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);急性腦梗死重癥組患者入院24小時(shí)、7天、14天血清和肽素水平分別顯著高于輕癥組患者對(duì)應(yīng)時(shí)間的血清和肽素水平,差異有統(tǒng)計(jì)學(xué)意義(P0.05);重癥組患者入院24小時(shí)、7天的NT-proBNP濃度明顯高于輕癥組患者,差異有統(tǒng)計(jì)學(xué)意義(P0.05),兩組14天的NT-proBNP差異無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論急性腦梗死患者血清和肽素、NT-proBNP水平升高,與急性腦梗死病情、發(fā)病時(shí)間有關(guān),觀察血清和肽素、NT-proBNP水平變化有助臨床急性腦梗死的診斷和治療。
[Abstract]:Objective to observe the changes of serum and peptide NT-proBNP levels in patients with acute cerebral infarction (ACI) and to explore the relationship between NT-proBNP and acute cerebral infarction (ACI) and its clinical significance. Methods 92 patients with acute cerebral infarction (ACI) in neurology department of our hospital were selected as study objects, and 90 healthy persons who took part in physical examination at the same time were selected as control group. Their general data were collected and the contents of NT-proBNP in serum and peptide were measured. The changes of serum and peptide levels of NT-proBNP in patients with acute cerebral infarction were compared between the two groups. Results the levels of serum peptide and NT-proBNP in patients with mild acute cerebral infarction and severe cerebral infarction were higher than those in control group. The levels of serum and peptide in patients with acute cerebral infarction were significantly higher than those in patients with mild cerebral infarction. The concentration of NT-proBNP in the severe group was significantly higher than that in the mild group at 24 hours and 7 days after admission, the difference was statistically significant (P 0.05). There was no significant difference in NT-proBNP between the two groups on the 14th day (P 0.05). Conclusion the elevated levels of NT-proBNP in serum and peptide in patients with acute cerebral infarction are related to the condition and onset time of acute cerebral infarction. It is helpful for the diagnosis and treatment of acute cerebral infarction to observe the changes of NT-proBNP in serum and peptide in patients with acute cerebral infarction.
【作者單位】： 北京市社會(huì)福利醫(yī)院;
【分類號(hào)】：R743.33

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