本文選題：自身免疫性腦炎 + 免疫調(diào)節(jié)藥物�。� 參考：《解放軍醫(yī)學(xué)雜志》2017年04期

【摘要】：自身免疫性腦炎是機體免疫系統(tǒng)對神經(jīng)元抗原成分產(chǎn)生異常免疫反應(yīng)所致的中樞神經(jīng)系統(tǒng)炎性疾病,通常被認(rèn)為是非感染因素引起的可逆轉(zhuǎn)性腦炎,其特征性臨床表現(xiàn)包括急性或亞急性起病的認(rèn)知功能障礙、癲癇發(fā)作及精神異常。隨著相關(guān)抗體的陸續(xù)發(fā)現(xiàn),各類臨床綜合征的總結(jié)提出,以及功能影像學(xué)工具的推廣應(yīng)用,自身免疫性腦炎的診斷流程日益規(guī)范。自身免疫性腦炎的治療以免疫調(diào)節(jié)為主,主要包括激素、人免疫球蛋白、血漿置換及免疫抑制劑的應(yīng)用,其他治療手段包括相關(guān)腫瘤的切除、電休克療法等。多數(shù)患者的臨床癥狀經(jīng)過積極治療可獲得實質(zhì)性改善。本文主要對自身免疫性腦炎治療的研究進(jìn)展進(jìn)行綜述。
[Abstract]:Autoimmune encephalitis is an inflammatory disease of the central nervous system caused by the abnormal immune response of the immune system to the antigens of neurons. It is generally considered to be a reversible encephalitis caused by non-infectious factors. Its characteristic clinical manifestations include acute or subacute cognitive impairment, seizures and mental disorders. With the discovery of related antibodies, the summary of clinical syndrome and the application of functional imaging tools, the diagnosis process of autoimmune encephalitis is becoming more and more standardized. The treatment of autoimmune encephalitis mainly includes hormone, human immunoglobulin, plasma exchange and the application of immunosuppressant. Other treatment methods include tumor resection, electroshock therapy and so on. The clinical symptoms of most patients can be substantially improved after active treatment. This article reviews the progress in the treatment of autoimmune encephalitis.
【作者單位】： 解放軍醫(yī)學(xué)院;解放軍總醫(yī)院神經(jīng)內(nèi)科;
【基金】：全軍醫(yī)學(xué)科技“十二五”科研項目(CWS11J064)~~
【分類號】：R742.9
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本文編號：1957238