本文選題：腦梗死 + 顱內(nèi)外動脈粥樣硬化�。� 參考：《中國動脈硬化雜志》2017年11期

【摘要】：目的探討腦梗死患者顱內(nèi)外動脈粥樣硬化與外周血T細(xì)胞亞群的相關(guān)性。方法將腦梗死組180例腦梗死患者按類肝素藥物治療急性缺血性腦卒中試驗(yàn)(TOAST)亞型分類標(biāo)準(zhǔn)分為大動脈粥樣硬化性腦梗死組(LAA組)、心源性栓塞組(CE組)、小動脈閉塞性腦梗死組(SAA組)、其他原因所致腦梗死(SOE組)組、不明原因腦梗死(SUE組);按頭頸CT血管造影(CTA)顱內(nèi)外動脈狹窄結(jié)果分為無狹窄組、單純顱外動脈狹窄組、單純顱內(nèi)動脈狹窄組、顱內(nèi)外動脈狹窄組,各狹窄組進(jìn)一步按狹窄程度分為輕、中及重度狹窄組。同時(shí)選取健康體檢者60例作為對照組。分別比較各組間血T細(xì)胞亞群水平。結(jié)果腦梗死組CD4+T細(xì)胞水平明顯高于對照組,CD8+T細(xì)胞水平明顯低于對照組(P0.05);LAA組和SAA組CD4+T細(xì)胞水平顯著高于其他類型腦梗死組及對照組,而CD8+T細(xì)胞水平呈相反表現(xiàn)(P0.05);顱內(nèi)外動脈狹窄嚴(yán)重程度與CD4+T細(xì)胞呈正相關(guān),與CD8+T細(xì)胞呈負(fù)相關(guān)。無狹窄組CD4+T細(xì)胞水平低于各狹窄組,CD8+T細(xì)胞水平高于各狹窄組(P0.05),而各狹窄組間T細(xì)胞亞群差異無統(tǒng)計(jì)學(xué)意義。結(jié)論 CD4+T細(xì)胞和CD8+T細(xì)胞與腦梗死患者動脈粥樣硬化密切相關(guān),檢測血T細(xì)胞亞群對顱內(nèi)外動脈粥樣硬化及其嚴(yán)重程度具有一定的預(yù)測價(jià)值。
[Abstract]:Objective to investigate the correlation between intracranial and extracranial atherosclerosis and T cell subsets in peripheral blood of patients with cerebral infarction. Methods 180 patients with cerebral infarction in cerebral infarction group were divided into two groups according to the subtype classification of heparin-like drug therapy in acute ischemic stroke test (TOAST): large artery atherosclerotic cerebral infarction group (ACI group), cardiac embolism group (CE group), arteriole occlusion group (CAO). Cerebral infarction group (SAA group, other causes of cerebral infarction) group (SOE group), According to the results of head and neck CT angiography (CTAA), the patients were divided into three groups: no stenosis group, simple extracranial artery stenosis group, simple intracranial artery stenosis group, and intracranial external artery stenosis group. Each stenosis group was further divided into light, moderate and severe stenosis groups according to the degree of stenosis. At the same time, 60 healthy persons were selected as control group. The levels of blood T cell subsets were compared in each group. Results the level of CD4 T cells in cerebral infarction group was significantly higher than that in control group (P 0.05) and SAA group (P 0.05). The level of CD4 T cell in cerebral infarction group was significantly higher than that in other cerebral infarction group and control group. However, the level of CD8 T cells was opposite to that of CD8 T cells, and the severity of intracranial and extracranial artery stenosis was positively correlated with CD4 T cells and negatively correlated with CD8 T cells. The level of CD4 T cells in no stenosis group was lower than that in each stenosis group and the level of CD8 T cell was higher than that in each stenosis group (P 0. 05), but there was no significant difference in T cell subsets among different stenosis groups. Conclusion CD4 T cells and CD8 T cells are closely related to atherosclerosis in patients with cerebral infarction. The detection of blood T cell subsets may be useful in predicting the severity and severity of intracranial and extracranial atherosclerosis.
【作者單位】： 安徽醫(yī)科大學(xué)第一附屬醫(yī)院神經(jīng)內(nèi)科;
【分類號】：R743.33

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