本文選題：前循環(huán)缺血性腦卒中 + 后循環(huán)缺血性腦卒中��； 參考：《中國藥房》2017年17期

【摘要】：目的:研究不同腦組織缺血范圍進展性腦卒中患者采用阿加曲班治療的臨床效果。方法:選擇2015年2月-2016年5月我院神經內科收治的進展性腦卒中患者116例,根據(jù)腦組織缺血范圍分為前循環(huán)(缺血)組60例、后循環(huán)(缺血)組50例、腔隙性(腦梗死)組6例。3組患者均采用基礎治療聯(lián)合阿加曲班治療,于病情加重當天及第2天采用阿加曲班60 mg/d靜脈持續(xù)泵入,病情緩解后的第5天減量為10 mg經靜脈持續(xù)泵入治療,3 h/次,bid,7 d為1個療程。比較3組患者美國國立衛(wèi)生院卒中量表(NIHSS)評分、改良RANKIN量表(m RS)評分、活化部分凝血活酶時間(APTT)及不良反應發(fā)生情況。結果:治療后14 d,3組患者NIHSS、m RS評分均較治療前顯著降低,差異均有統(tǒng)計學意義(P0.05);且前循環(huán)組與后循環(huán)組比較,差異有統(tǒng)計學意義(P0.05)。治療2 h時,3組患者APTT均較治療前顯著延長,且腔隙性組最為明顯,組間比較差異有統(tǒng)計學意義(P0.05);治療48 h時,3組患者APTT均恢復至正常水平,組間比較差異無統(tǒng)計學意義(P0.05)。3組患者均未見明顯不良反應發(fā)生。結論:阿加曲班治療不同腦組織缺血范圍的進展性腦卒中均能取得顯著療效,且安全性高;尤其是針對前循環(huán)缺血性腦卒中患者顯效快、抗凝效果顯著。
[Abstract]:Objective: to study the clinical effect of Agatriban in patients with progressive stroke with different ischemic range. Methods: 116 patients with progressive stroke treated in neurology department of our hospital from February 2015 to May 2016 were divided into anterior circulation group (60 cases) and posterior circulation group (50 cases) according to the ischemic range of brain tissue. In the lacunar (cerebral infarction) group, 6 patients in group 3 were treated with basic therapy combined with agatropine, and the patients were continuously injected with Agatripine for 60 mg/d on the day of aggravation and the second day. On the 5th day after remission, the dosage of 10 mg was continuously injected intravenously for 3 h / time for 7 days as a course of treatment. NIHSS score, modified RANKIN scale, activated partial thromboplastin time (APTT) and adverse events were compared among the three groups. Results: after 14 days of treatment, the NIHSS mRS scores in the three groups were significantly lower than those before treatment, and the difference was statistically significant (P 0.05), and the difference between the anterior circulation group and the posterior circulation group was statistically significant (P 0.05). At 2 h after treatment, the APTT of the 3 groups was significantly longer than that of before treatment, and the lacunar group was the most obvious, and the difference between the three groups was statistically significant (P 0.05), and the APTT of the 3 groups returned to the normal level at 48 h after treatment. There was no significant difference between the two groups. Conclusion: the treatment of progressive stroke with different ischemic range of cerebral tissue by Agatripine has significant curative effect and high safety, especially for the patients with anterior circulation ischemic stroke, and the anticoagulant effect is remarkable.
【作者單位】： 天津港口醫(yī)院藥劑科;天津港口醫(yī)院麻醉科;天津港口醫(yī)院神經內科;
【分類號】：R743.3

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本文編號：1941992