本文選題：型糖尿病 + 腦微血管病變��； 參考：《中國(guó)藥房》2017年15期

【摘要】：目的:觀察天芪降糖膠囊聯(lián)合二甲雙胍治療老年2型糖尿病伴腦微血管病變的療效和安全性。方法:96例老年2型糖尿病伴腦微血管病變患者隨機(jī)分為對(duì)照組(48例)和觀察組(48例)。對(duì)照組患者給予鹽酸二甲雙胍片0.5 g,口服,每日3次;觀察組患者在對(duì)照組治療的基礎(chǔ)上給予天芪降糖膠囊1.6 g,口服,每日3次。兩組均用藥4周。觀察兩組患者的臨床療效,治療前后中醫(yī)證候總積分、血糖水平[空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血紅蛋白(Hb A1c)]、血脂水平[總膽固醇(TC)、三酰甘油(TG)、高密度脂蛋白膽固醇(HDL-C)、低密度脂蛋白膽固醇(LDL-C)]、超敏C反應(yīng)蛋白(hs-CRP)和內(nèi)皮素-1(ET-1)水平、血液流變學(xué)指標(biāo)、氧化應(yīng)激指標(biāo)[丙二醛(MDA)、超氧化物歧化酶(SOD)]及不良反應(yīng)發(fā)生情況。結(jié)果:觀察組患者總有效率顯著高于對(duì)照組(89.58%vs.70.83%),差異有統(tǒng)計(jì)學(xué)意義(P0.05)。治療后,兩組患者中醫(yī)證候總積分和血糖、hs-CRP、ET-1、TC、TG、LDL-C、血液流變學(xué)指標(biāo)、MDA水平均顯著低于同組治療前,且觀察組中醫(yī)證候總積分、FPG、2 h PG、hs-CRP、ET-1、TC、TG、LDL-C、血液流變學(xué)指標(biāo)、MDA水平均顯著低于對(duì)照組;兩組患者SOD水平均顯著高于同組治療前,且觀察組顯著高于對(duì)照組,同時(shí)觀察組HDL-C水平顯著高于同組治療前及對(duì)照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。兩組患者治療期間均未見(jiàn)明顯不良反應(yīng)發(fā)生。結(jié)論:天芪降糖膠囊聯(lián)合二甲雙胍治療老年2型糖尿病伴腦微血管病變的療效顯著,可降低血糖、血脂水平,改善機(jī)體血液流變學(xué)狀態(tài)及氧化應(yīng)激反應(yīng),且安全性較好。
[Abstract]:Objective: To observe the efficacy and safety of Tianqi Jiangtang Capsule Combined with metformin in the treatment of senile type 2 diabetes with cerebral microvascular disease. Methods: 96 elderly patients with type 2 diabetes with cerebral microvascular disease were randomly divided into control group (48 cases) and observation group (48 cases). The control group was given 0.5 g of Metformin Hydrochloride Tablets, orally, 3 times a day; On the basis of the control group, the patients were given Tianqi Jiangtang Capsule 1.6 g, oral, 3 times a day. Two groups were used for 4 weeks. The clinical efficacy of the two groups was observed. The total score of TCM syndrome, blood glucose level [FPG), postprandial 2 h blood glucose (2 h PG), glycated hemoglobin (Hb A1c)], blood lipid level [total cholesterol (TC), and three glycerin (T) (T) were observed. G), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C)], hypersensitive C reactive protein (hs-CRP) and endothelin -1 (ET-1) level, blood rheology index, oxidative stress index [malondialdehyde (MDA), superoxide dismutase (SOD)] and ungood reaction. Results: the total effective rate of the patients in the observation group was significantly higher than that of the control group (89.5 8%vs.70.83%), the difference was statistically significant (P0.05). After treatment, the total score of TCM syndromes and blood sugar, hs-CRP, ET-1, TC, TG, LDL-C, the hemorrheology index and the level of MDA were significantly lower than those of the same group, and the total score of TCM syndrome, FPG, and 2 h PG in the observation group were significantly lower than those of the two groups. In the control group, the level of SOD in the two groups was significantly higher than that before the same group, and the observation group was significantly higher than the control group. At the same time, the level of HDL-C in the observation group was significantly higher than the same group before and in the control group. The difference was statistically significant (P0.05). There was no obvious adverse reaction in the two groups during the treatment. Conclusion: Tianqi Jiangtang Capsule Combined with metformin. The treatment of senile type 2 diabetes with cerebral microvascular disease has a significant effect. It can reduce blood sugar, blood lipid level, improve the body's Hemorrheology and oxidative stress, and it has good safety.
【作者單位】： 唐山市工人醫(yī)院內(nèi)分泌科;唐山市工人醫(yī)院危重癥內(nèi)科;唐山市工人醫(yī)院呼吸危重癥內(nèi)科;
【分類號(hào)】：R587.2;R743

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本文編號(hào)：1939822