本文選題：重復(fù)經(jīng)顱磁刺激 + 帕金森病�。� 參考：《臨床神經(jīng)病學(xué)雜志》2017年05期

【摘要】：目的探討重復(fù)經(jīng)顱磁刺激(r TMS)治療早期帕金森病(PD)抑郁及睡眠障礙的臨床療效。方法選取Hoehn-Yahr分級(jí)1~2級(jí)的PD患者64例,按照隨機(jī)數(shù)字表法隨機(jī)分為治療組(31例)和假刺激組(33例)。治療組用r TMS 5 Hz高頻刺激患者雙側(cè)前額葉背外側(cè)(DLPFC)區(qū)共10 d,假刺激組接受假刺激治療共10 d。觀察治療前后兩組患者的漢密爾頓抑郁量表(HAMD)、PD睡眠量表(PDSS)、PD統(tǒng)一評(píng)定量表第Ⅲ部分(UPDRSⅢ)、外周血IL-6水平、腦內(nèi)神經(jīng)遞質(zhì)5-羥色胺(5-HT)、去甲腎上腺素(NE)、多巴胺(DA)含量的變化。結(jié)果與治療前相比,治療組患者治療后及治療后1個(gè)月時(shí)HAMD評(píng)分、UPDRSⅢ評(píng)分均明顯降低;PDSS評(píng)分均明顯升高(均P0.05)。與假刺激組同時(shí)間點(diǎn)相比,治療組患者治療后及治療后1個(gè)月時(shí)HAMD評(píng)分、UPDRSⅢ評(píng)分均明顯降低;PDSS評(píng)分均明顯升高(均P0.05)。與治療前相比,治療組患者治療后外周血IL-6水平及腦內(nèi)5-HT、NE、DA水平均顯著升高(均P0.05)。與假刺激組同時(shí)間點(diǎn)相比,治療組患者治療后外周血IL-6水平及腦內(nèi)5-HT、NE、DA水平均顯著升高(均P0.05)。結(jié)論高頻r TMS刺激DLPFC區(qū)可短期改善早期PD患者的抑郁及睡眠障礙。
[Abstract]:Objective to investigate the clinical efficacy of repeated transcranial magnetic stimulation (TMS) in the treatment of early PD depression and sleep disorder. Methods Sixty-four PD patients with Hoehn-Yahr grade 1 or 2 were randomly divided into treatment group (n = 31) and sham stimulation group (n = 33). The patients in the treatment group were treated with r TMS 5 Hz high frequency stimulation for 10 days in the bilateral dorsolateral prefrontal cortex, and in the sham stimulation group for 10 days. Before and after treatment, the changes of Hamilton Depression scale (Hamd) and PD Sleep scale (PDSS / PD) were observed. The levels of IL-6 in peripheral blood and the contents of neurotransmitters 5-HT, 5-HT, NE, DA DAA in the brain were measured. Results after treatment and 1 month after treatment, the HAMD score and the UPDRS 鈪，

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