發(fā)布時間：2018-05-23 09:26

  本文選題：多系統(tǒng)萎縮 + 功能磁共振　； 參考：《南京醫(yī)科大學學報(自然科學版)》2017年04期

【摘要】：目的:采用靜息態(tài)功能磁共振(resting state functional magnetic resonance image,rs-f MRI)方法探討不同亞型多系統(tǒng)萎縮(multiple system atrophy,MSA)患者腦局部一致性(regional homogeneity,ReHo)的變化及其與臨床癥狀嚴重程度的相關性。方法:對48例MSA患者(MSA-C型28例及MSA-P型20例)和27例健康對照進行rs-f MRI掃描,比較3組間ReHo的差異,采用簡易精神狀態(tài)量表(MMSE)、蒙特利爾認知評估量表(MoCA)、統(tǒng)一的MSA評分量表(UMSARS)等評估臨床癥狀,并分析MSA患者ReHo值與臨床癥狀嚴重程度之間的關系。結果:(1)相對于對照組,MSA-C組雙側楔前葉、左側海馬、左側枕中回、小腦蚓部Ⅴ~ⅥReHo增高,左側小腦前/后葉ReHo減低;MSA-P組雙側丘腦、左側尾狀核、腦干、小腦蚓部ⅤReHo增高,左側小腦前/后葉ReHo減低;相對于MSA-P組,MSA-C組左側楔前葉、左側海馬、左側顳中回ReHo增高,右側枕中回ReHo減低。(2)MSA-C組雙側楔前葉與MoCA評分呈負相關,MSA-P組雙側丘腦與UMSARS-Ⅱ評分呈正相關。結論:靜息態(tài)下MSA患者存在局部腦區(qū)的神經元活動一致性異常,這些腦區(qū)異常可能與MSA的病理機制有關。
[Abstract]:Objective: to investigate the changes of regional homogeneity in brain of patients with different subtypes of multiple system atrophy (system atrophy) by resting state functional magnetic resonance imageres-f MRIs and its correlation with the severity of clinical symptoms. Methods: rs-f MRI scans were performed in 48 MSA patients with MSA-C type and 20 patients with MSA-P type) and 27 healthy controls. The difference of ReHo among the three groups was compared. The clinical symptoms were evaluated with the mini-mental state scale (MMSE), the Montreal Cognitive Assessment scale (Montreal Cognitive Assessment scale) and the Unified MSA scale (UMSARS). The relationship between the ReHo value and the severity of clinical symptoms in patients with MSA was analyzed. Results compared with MSA-C group, the left hippocampus, left middle occipital gyrus, 鈪，

本文編號：1924170