本文選題：格林-巴利綜合征 + 神經(jīng)免疫��； 參考：《中國(guó)全科醫(yī)學(xué)》2017年15期

【摘要】：目的探討吉蘭-巴雷綜合征(GBS)患者年齡與神經(jīng)根免疫反應(yīng)的關(guān)系及其臨床意義。方法選取2006年1月—2016年6月在南昌大學(xué)第五附屬醫(yī)院神經(jīng)內(nèi)科住院的符合納入標(biāo)準(zhǔn)的GBS患者78例為研究對(duì)象。按照年齡將患者分為年輕組(≤45歲,32例)和年老組(45歲,46例)�；仡櫺允占疓BS患者一般資料[包括性別、年齡、GBS肢體殘疾量表評(píng)分(Hughes評(píng)分)、上呼吸道感染、胃腸感染]以及監(jiān)測(cè)神經(jīng)根免疫反應(yīng)的生化指標(biāo)(腦脊液蛋白、IgG)水平。根據(jù)腦脊液蛋白、IgG參考值,將患者分為腦脊液蛋白正常組(14例)與腦脊液蛋白偏高組(64例)以及腦脊液IgG正常組(19例)與腦脊液IgG偏高組(59例)。結(jié)果年輕組與年老組性別、上呼吸道感染發(fā)生率、胃腸感染發(fā)生率比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);年輕組Hughes評(píng)分≥3分率、腦脊液蛋白水平、腦脊液IgG水平低于年老組(P0.05)。腦脊液蛋白正常組年齡小于腦脊液蛋白偏高組(P0.05)。腦脊液IgG正常組年齡小于腦脊液IgG偏高組(P0.05)。年齡與腦脊液蛋白、IgG水平均呈正相關(guān)(r=0.331,P0.01;r=0.277,P=0.01)。結(jié)論 GBS患者神經(jīng)根免疫反應(yīng)程度隨著患者年齡的增加而增強(qiáng),臨床評(píng)估GBS患者神經(jīng)根免疫反應(yīng)時(shí)應(yīng)考慮年齡因素。
[Abstract]:Objective to investigate the relationship between age and nerve root immune response in patients with Guillain-Barre syndrome (GBS) and its clinical significance. Methods from January 2006 to June 2016, 78 patients with GBS who were hospitalized in Department of Neurology, Fifth affiliated Hospital of Nanchang University were selected as subjects. According to the age, the patients were divided into young group (鈮，

本文編號(hào)：1915560