肝豆?fàn)詈俗冃圆』颊哂洃洷O(jiān)測及道德判斷的神經(jīng)心理學(xué)研究
發(fā)布時間：2018-05-16 07:37
本文選題：肝豆?fàn)詈俗冃圆?/strong> + 記憶監(jiān)測 ； 參考：《安徽醫(yī)科大學(xué)》2014年碩士論文
【摘要】：目的記憶監(jiān)測是個體對自身記憶狀況的總體把握；道德判斷指的是人們根據(jù)自己心目中的道德準(zhǔn)則，按照所處特定文化或亞文化環(huán)境中規(guī)定的美好品德的標(biāo)準(zhǔn)，對個體行為進行好或壞的評價。記憶監(jiān)測和道德判斷的神經(jīng)基礎(chǔ)尚不十分明了，主要涉及的部位均位于前額葉。肝豆?fàn)詈俗冃圆』颊咂�、基底�?jié)等區(qū)域廣受累及，伴有多種認知能力受損，但尚無其記憶監(jiān)測與道德判斷的行為學(xué)研究。本文通過研究肝豆?fàn)詈俗冃圆。╤epatolenticular degeneration，HLD）患者記憶監(jiān)測及道德判斷的情況，進一步了解HLD患者記憶監(jiān)測障礙和道德感下降的損害特征，并探討其可能的機制。 方法選取在安徽中醫(yī)藥大學(xué)神經(jīng)病學(xué)研究所附屬醫(yī)院神經(jīng)科病房住院診斷為肝豆?fàn)詈俗冃圆〉幕颊呒?0名人口學(xué)數(shù)據(jù)匹配的健康被試，進行知道感及道德兩難情境決策的實驗。采用SPSS17.0對數(shù)據(jù)進行統(tǒng)計學(xué)分析，采用兩獨立樣本t檢驗及Pearson相關(guān)分析進行研究，以P＜0.05為差異有統(tǒng)計學(xué)意義。實驗一：建立情景記憶(EM)及語義記憶(SM)的知道感(feeling-of-knowing，F(xiàn)OK)實驗范式，對30例WD患者及30例年齡及教育程度相匹配的健康對照者（HC）進行研究。實驗二：漢化使用Joshua D. Greene編寫的道德兩難問卷，問卷包括50個假設(shè)，，被試讀題后作出“愿意這樣做”或“不愿意這樣做”的判斷,對實驗一中30例WD患者及30例年齡及教育程度相匹配的健康對照者（HC）進行研究。結(jié)果實驗一：與HC組的FOK-EM的線索回憶率（64.17%±29.21%）以及FOK-SM的線索回憶率（84.72%±11.44%）比較，HLD患者組FOK-EM的線索回憶率（26.55%±20.92%）、FOK-SM的線索回憶率（53.93%±28.42%）顯著降低，差異有統(tǒng)計學(xué)意義（t=-5.140,p0.01;t=-5.123,p0.01）；FOK-EM的肯定判斷/正確再認成績（50.64%±29.43%）、否定判斷/正確再認成績（12.80%±18.32%）與HC組的肯定判斷/正確再認成績（75.15%±31.73%）、否定判斷/正確再認成績（1.81%±5.41%）之間差異有統(tǒng)計學(xué)意義（t=-2.693,p0.05;t=3.026,p0.01）；且stroop效應(yīng)與FOK-EM的否定判斷/正確再認成績呈正相關(guān)（r=0.601，p0.01）。實驗二：HLD患者與健康對照在“個人情感的”道德判斷中做出愿意（功利主義傾向）選擇的概率顯著的大于健康對照（t=3.908，p0.01），在“非個人情感的”道德判斷和“道德無關(guān)的”判斷中做出“愿意”回答的概率差異無統(tǒng)計學(xué)意義。 結(jié)論HLD患者的情景記憶監(jiān)測受損，表現(xiàn)為對自身再認能力的低估，這種記憶監(jiān)測受損與執(zhí)行功能的損害相關(guān)，推測前額葉功能損傷可能是導(dǎo)致HLD患者情景記憶障礙的重要因素；同時患者的語義記憶監(jiān)測相對保留，提示語義記憶的知道感與情景記憶的知道感神經(jīng)機制是不同的�；颊咴凇皞�人情感的”道德判斷中高度傾向于功利主義選擇，推測與前額葉功能不足，道德決策過程中負性情緒加工障礙有關(guān)。前額葉與基底節(jié)之間直接和間接環(huán)路的損傷可能是HLD患者出現(xiàn)以上表現(xiàn)的神經(jīng)基礎(chǔ)。
[Abstract]:Objective memory monitoring is an individual's overall grasp of his or her own memory. Moral judgment refers to the standard of good character defined by people according to their own moral norms and according to their specific cultural or subcultural environment. A good or bad assessment of an individual's behavior. The neural basis of memory monitoring and moral judgment is not well understood, and the main sites involved are located in the prefrontal lobe. The cortical and basal ganglia were extensively involved in patients with hepatolenticular degeneration, accompanied by a variety of cognitive impairment, but there was no behavioral research on their memory monitoring and moral judgment. By studying the memory monitoring and moral judgment of patients with hepatolenticular degeneration-induced disease (HLD), we further understand the characteristics of impaired memory monitoring and moral decline in patients with HLD, and explore its possible mechanism. Methods 30 healthy subjects who were diagnosed as hepatolenticular degeneration in the neurology ward of the affiliated Hospital of Institute of Neurology of Anhui University of traditional Chinese Medicine and 30 healthy subjects with matched demographic data were selected to conduct the knowledge sense and moral dilemma decision making experiment. SPSS17.0 was used to analyze the data, two independent samples t test and Pearson correlation analysis were used to study the data. The difference was statistically significant (P < 0. 05). Experiment 1: to study 30 WD patients and 30 healthy controls matched with age and education by establishing the perception-of-knowing FOK paradigm of situational memory (EMM) and semantic memory (SMSM). Experiment 2: the Chinese version of the moral dilemmas questionnaire, written by Joshua D. Greene, consisted of 50 hypotheses. After reading the questions, the subjects made a judgment of "willing to do this" or "not willing to do so". In experiment 1, 30 WD patients and 30 healthy controls matched with age and education were studied. Results in experiment 1, compared with HC group (64.17% 鹵29.21%) and FOK-SM group (84.72% 鹵11.44%), the clue recall rate of FOK-EM group (26.55% 鹵20.92% 鹵28.42%) was significantly lower than that of HC group (53.93% 鹵28.42%). The difference was statistically significant between the positive judgment / correct recognition of FOK-EM (50.64% 鹵29.43%, negative judgment / correct recognition 12.80% 鹵18.32%) and the positive judgment / correct recognition of 75.15% 鹵31.737.30% in HC group and 1.81% 鹵5.41% in negative judgment / correct recognition score. There was a positive correlation between the stroop effect and the negative judgment / correct recognition of FOK-EM. Experiment 2: HLD patients and healthy controls were significantly more likely to make a willing (utilitarian) choice in "personal emotional" moral judgment than the healthy control (t = 3.908 / p 0.01), and had no relationship with "non-personal emotional" moral judgment. There was no statistically significant difference in the probability of making a willing answer in the judgment. Conclusion the impairment of situational memory monitoring in patients with HLD is characterized by an underestimation of their recognition ability. The impairment of memory monitoring is related to the impairment of executive function. It is speculated that the impairment of prefrontal function may be an important factor leading to the impairment of situational memory in patients with HLD. At the same time, the patients' semantic memory monitoring is relatively reserved, suggesting that the sense of knowledge in semantic memory is different from that in situational memory. The patients were highly inclined to utilitarianism in the moral judgment of personal emotion, which was related to the deficiency of prefrontal function and the negative emotional processing disorder in the process of moral decision. The injury of direct and indirect loop between the prefrontal lobe and basal ganglia may be the neural basis of the above findings in HLD patients.
【學(xué)位授予單位】：安徽醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R742.4
【參考文獻】
相關(guān)期刊論文 前5條
1 鳳兆海;汪凱;朱春燕;王長青;孟玉;周農(nóng);;基底節(jié)卒中患者面孔情緒認知障礙的研究[J];臨床神經(jīng)病學(xué)雜志;2006年04期
2 沈大為,韓凱;FOK判斷產(chǎn)生機制的研究進展[J];心理科學(xué);1999年02期
3 金景;江鐘立;賀丹軍;孟殿懷;;基底核卒中對執(zhí)行功能和學(xué)習(xí)能力的影響[J];中國康復(fù)醫(yī)學(xué)雜志;2009年05期
4 汪凱,楊任民,Ramjahn Hoosain;Wilson病患者的厭惡情緒加工障礙[J];中華神經(jīng)科雜志;2003年02期
5 王娟;張芳芳;韓永升;王訓(xùn);韓詠竹;汪凱;;Wilson病患者眼區(qū)情緒認知障礙的研究[J];中國神經(jīng)精神疾病雜志;2012年05期
本文編號：1896012
本文鏈接：http://sikaile.net/yixuelunwen/shenjingyixue/1896012.html
最近更新
教材專著
