本文選題：吉蘭-巴雷綜合征 + 流行特征　； 參考：《中國疫苗和免疫》2016年06期

【摘要】：目的分析河南省兒童吉蘭-巴雷綜合征(Guillain-Barre Syndrome,GBS)流行病學(xué)特征,為兒童GBS病例的管理和預(yù)防提供科學(xué)參考。方法用描述性分析方法對2004~2015年河南省報告0~14歲兒童GBS病例進(jìn)行分析。結(jié)果 2004~2015年河南省共報告0~14歲兒童GBS病例1 593例,平均發(fā)病率為0.69/10萬,各年發(fā)病率在0.48/10萬(95例,2014年)~0.83/10萬(152例,2006年)之間(趨勢檢驗,x2=41.16,P=0.000)。各地區(qū)發(fā)病率在0.29/10萬(58例,信陽市)~1.03/10萬(15例,濟(jì)源市)之間。年齡別發(fā)病率在0.22/10萬(35例,14歲)~1.86/10萬(313例,1歲)之間。男、女性發(fā)病率分別為0.81/10萬、0.54/10萬。6~8月份報告506例(31.76%)。GBS病例腸道病毒分離率為13.81%(220/1 593)。401例(25.17%)病例60天后隨訪有殘留麻痹。結(jié)論河南省0~14歲兒童GBS發(fā)病率呈逐年下降趨勢,以小年齡、男性兒童多發(fā),呈夏秋季高峰。需進(jìn)一步加強(qiáng)兒童GBS監(jiān)測和殘留麻痹病例的早期康復(fù)治療。
[Abstract]:Objective to analyze the epidemiological characteristics of Guillain-Barre Syndromefus (GBS) in children with Guillain-Barre syndrome in Henan Province, and to provide a scientific reference for the management and prevention of children with GBS. Methods descriptive analysis was used to analyze the GBS cases reported from 2004 to 2015 in children aged 0 to 14 years in Henan Province. Results from 2004 to 2015, 1 593 cases of GBS were reported in Henan Province. The average incidence rate was 0.69 / 100 000. The annual incidence was 0.48 / 100 000 cases, and in 2014 ~ 0.83% / 100 000 cases, 152 cases were reported in Henan Province (trend test: 41.16%, 0.000%). The incidence rate was 0.29 / 100 000 cases in different regions, 10 3 / 100 000 cases in Xinyang City and 15 cases in Jiyuan City. The age-specific incidence was between 0.22 / 100 000 / 35 / 14 years old / 18.6 / 100 000 / 313 / 1 year old. The incidence of enterovirus in male and female were 0.81 / 100 000 and 0.54 / 100,000 respectively. In August, 506 cases with GBS were reported to have residual paralysis after 60 days follow-up. The rate of enterovirus isolation was 13.81 / 220 / 1593 / 401 (P < 0.05). Conclusion the incidence of GBS in children aged 14 years old in Henan Province is decreasing year by year. The incidence rate of GBS in male children is more than that in young age, and it is the peak in summer and autumn. GBS monitoring and early rehabilitation of children with residual paralysis need to be further strengthened.
【作者單位】： 河南省疾病預(yù)防控制中心;
【基金】：2015年度河南省醫(yī)學(xué)科技攻關(guān)計劃項目(201504049) 河南省2016年科技攻關(guān)項目(162102310036)
【分類號】：R745.43

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