本文選題：RDW + 急性腦梗死��； 參考：《皖南醫(yī)學(xué)院》2016年碩士論文

【摘要】：目的:研究紅細(xì)胞分布寬度(RDW)與急性腦梗死之間的相關(guān)性,分析RDW對其病情及預(yù)后評估的臨床價(jià)值。方法:收集篩選本院2014年1月至2016年1月的100例發(fā)病時(shí)間不超過48小時(shí)的通過頭顱MRI確診的急性腦梗死(腔隙性腦梗死除外)患者作為急性腦梗死組(ACI組),并進(jìn)行NIHSS評分。選取同期在健康體檢中心參加體檢的健康人100例作為健康對照組。于入院次日晨空腹采集血靜脈血進(jìn)行血常規(guī)、生化全套等常規(guī)實(shí)驗(yàn)室檢查,比較兩組的RBC計(jì)數(shù)、血紅蛋白濃度(Hb)、紅細(xì)胞比容(HCT)、紅細(xì)胞平均體積(MCV)及紅細(xì)胞分布寬度(RDW)、血漿總蛋白(TP),球蛋白(Glb)、白蛋白(Alb)水平,計(jì)算白球比(A/G)、甘油三酯(TG)、膽固醇(TC)、低密度脂蛋白(LDL)、高密度脂蛋白(H D L)。將ACI組根據(jù)NIHSS評分分為NIHSS≥8分組及NIHSS8分組,比較兩組實(shí)驗(yàn)室檢查指標(biāo)。結(jié)果使用SPSS19.0軟件進(jìn)行統(tǒng)計(jì)學(xué)處理。結(jié)果:1.ACI組的RDW水平與健康相比較明顯升高,且差異有顯著的統(tǒng)計(jì)學(xué)意義(P0.001);而兩組相比較,其他的紅細(xì)胞參數(shù)RBC、Hb、MCV、HCT差異無統(tǒng)計(jì)學(xué)意義。2.ACI組血漿總蛋白(TP)水平低于對照組,兩組差異有統(tǒng)計(jì)學(xué)意義(P0.01);ACI組的球蛋白(Glb)水平高于對照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);ACI組的白蛋白(Alb)低于對照組,白球比(A/G)低于對照組,差異有統(tǒng)計(jì)學(xué)意義(P0.001)。3.ACI組甘油三酯水平略高于對照組,但差異無統(tǒng)計(jì)學(xué)意義(P0.05),ACI組的高密度脂蛋白(HDL)水平比健康對照組的低,差異有統(tǒng)計(jì)學(xué)意義(P0.05);ACI組的總膽固醇(TC)水平比對照組高,差異有統(tǒng)計(jì)學(xué)意義(P0.05);ACI組的低密度脂蛋白(LDL)水平明顯比健康對照組高,差異具有明顯統(tǒng)計(jì)學(xué)意義(P0.01)。4.NHISS評分"g8分組的急性腦梗死患者的RDW水平高于NHISS評分8分組患者的RDW水平,且兩組差異有統(tǒng)計(jì)學(xué)意義,P=0.0440.05。5.采用Pearson相關(guān)分析,在ACI組NIHSS評分與RDW水平呈正相關(guān)(相關(guān)系數(shù)r=0.722,P0.01)。6.采用Pearson相關(guān)分析,ACI組的RDW水平與Alb水平呈負(fù)相關(guān)(r=-0.264,P=0.0080.01);RDW水平與A/G呈負(fù)相關(guān)(r=-0.219,P=0.0280.05)。結(jié)論:1.ACI組患者的RDW水平明顯高于健康對照組,提示RDW水平升高可能為腦梗死的獨(dú)立危險(xiǎn)因子。2.ACI組血漿總蛋白(TP)水平低于對照組,球蛋白(Glb)水平高于對照組,白蛋白(Alb)低于對照組,白球比(A/G)低于對照組,提示總蛋白(TP)水平降低、白蛋白(Alb)水平降低、A/G降低,球蛋白(Glb)升高與急性腦梗死密切相關(guān)。3.RDW水平與Alb水平及A/G呈負(fù)相關(guān),提示RDW水平升高、Alb水平降低及A/G降低都可以作為急性腦梗死的危險(xiǎn)因素。4.高密度脂蛋白(HDL)水平降低、總膽固醇(TC)水平升高、密度脂蛋白(LDL)水平升高與腦梗死相關(guān)。5.RDW水平與患者的神經(jīng)功能損害的程度呈現(xiàn)正相關(guān),提示RDW水平升高能夠反映病情的發(fā)展程度。
[Abstract]:Objective: to study the correlation between RDW and acute cerebral infarction (ACI), and to analyze the clinical value of RDW in evaluating its condition and prognosis. Methods: from January 2014 to January 2016, 100 patients with acute cerebral infarction (except lacunar infarction) diagnosed by cranial MRI were selected as acute cerebral infarction group (ACI group), and their NIHSS scores were evaluated. 100 healthy persons who took part in the physical examination center in the same period were selected as the healthy control group. Blood venous blood was collected on an empty stomach in the morning after admission for routine laboratory examination, such as blood routine examination and biochemical complete set. The RBC counts of the two groups were compared. The levels of HB, HCT, MCV (mean volume of RBC), RDWN, TPN, GlbN, Alb) were measured. The white ball ratio was calculated as A / R, TG, TG, TC, LDLN and HDL-C. According to NIHSS score, ACI group was divided into NIHSS 鈮，

本文編號：1843864