本文選題：癲癇 + 嚴重程度�。� 參考：《蘇州大學》2014年碩士論文

【摘要】：目的：研究癲癇患者外周血免疫球蛋白、補體的變化，及其與癲癇嚴重程度的相關性。 方法：應用散射比濁法檢測57例未服藥癲癇患者、46例規(guī)律服藥三個月以上癲癇患者及54例健康對照組外周血免疫球蛋白、補體濃度，，對未服藥癲癇患者使用NHS3量表評估癲癇嚴重程度。 結果：癥狀性癲癇組、非癥狀性癲癇組未服藥前外周血清IgG、IgA濃度均較對照組明顯下降（P 0.05），而外周血清IgM、C3、C4濃度與對照組相比差異無統(tǒng)計學意義。多因素Logistic回歸分析提示癲癇嚴重程度NHS3評分與血清IgA濃度呈負相關（β值=-4.948，P=0.004）。未服藥癲癇患者血清IgG、IgA濃度較正常對照組下降，差異有統(tǒng)計學意義（P 0.05），有癲癇史且經(jīng)正規(guī)抗癲癇藥物治療三月以上組血清IgG、IgA濃度較未服藥癲癇組均升高,血清IgG濃度差異有統(tǒng)計學意義，血清IgA濃度差異無統(tǒng)計學意義。 結論：癲癇患者在抗癲癇藥物治療前已存在免疫功能的紊亂，且癲癇嚴重程度與血清IgA濃度呈負相關。抗癲癇藥物治療對癲癇患者的免疫功能改善可能有幫助。
[Abstract]:Objective: to study the changes of immunoglobulin and complement in peripheral blood of epileptic patients and their correlation with the severity of epilepsy. Methods: the concentrations of immunoglobulin and complement in peripheral blood of 57 patients with epilepsy without taking medicine and 54 healthy controls were detected by scatter turbidimetry. NHS3 scale was used to evaluate the severity of epilepsy. Results: the IgA concentration in peripheral blood of symptomatic epilepsy group and non-symptomatic epilepsy group was significantly lower than that of control group (P 0.05), but there was no significant difference between the control group and the control group. Multivariate Logistic regression analysis showed that the NHS3 score of the severity of epilepsy was negatively correlated with the serum IgA concentration (尾 = -4.948, P = 0.004). The level of serum IgGG _ 3 in patients with epilepsy without medication was lower than that in the control group (P 0.05), and the serum IgA level of patients with epilepsy history and more than three months after regular antiepileptic treatment was higher than that of the control group. There was significant difference in serum IgG concentration, but no significant difference in serum IgA concentration. Conclusion: there is a disorder of immune function in epileptic patients before antiepileptic drug therapy, and the severity of epilepsy is negatively correlated with serum IgA concentration. Antiepileptic drug therapy may be helpful to improve the immune function of epileptic patients.
【學位授予單位】：蘇州大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R742.1

【參考文獻】

相關期刊論文 前9條

1 徐家立,劉玉璽;癲癇與免疫及其研究進展[J];國外醫(yī)學.神經(jīng)病學神經(jīng)外科學分冊;2000年04期

2 朱長庚;神經(jīng)-免疫-內分泌網(wǎng)絡與癲癇發(fā)病機理的關系[J];解剖學報;2002年03期

3 遲兆富,曹麗麗,尚偉,謝安木,周盛年,張雅萍;癲癇患者IFN-r、T細胞亞群及HLA-DR的檢測[J];上海免疫學雜志;1997年01期

4 劉忠強，申黎青，解學孔，李延年;癲癇病人血清IgA的動態(tài)觀察[J];上海免疫學雜志;1994年03期

5 林忠東,胡鴻文;癲癇患兒的T細胞亞群和白細胞介素2的研究[J];實用兒科臨床雜志;1998年03期

6 茍鵬;兒童癲癇的免疫進展[J];現(xiàn)代預防醫(yī)學;2005年04期

7 李海波,郭虎,胡曉蘭,陳麗瓊,梁東;癲癇患兒紅細胞粘附功能和補體C_3水平變化的研究[J];中國婦幼保健;2004年02期

8 林忠東,胡鴻文;癲癇患兒血清IgA和抗腦抗體的改變[J];中華兒科雜志;1997年08期

9 陳艷坤;劉詩翔;;干細胞移植治療癲沲的最新研究進展[J];卒中與神經(jīng)疾病;2011年06期

本文編號：1842859