發(fā)布時(shí)間：2018-05-03 18:40

  本文選題：腦卒中后抑郁 + 額葉�。� 參考：《山東醫(yī)藥》2017年19期

【摘要】：目的觀(guān)察腦卒中后抑郁(PSD)大鼠大腦情感障礙相關(guān)腦區(qū)額葉、海馬、杏仁核神經(jīng)元數(shù)量變化。方法將20只健康成年雌性SD大鼠隨機(jī)分為抑郁組、卒中組、PSD組和對(duì)照組,每組5只。抑郁組采用孤養(yǎng)法加以慢性不可預(yù)見(jiàn)的中等強(qiáng)度應(yīng)激刺激(CUMS)制作抑郁模型。卒中組用線(xiàn)栓法建立腦卒中模型。PSD組先用線(xiàn)栓法建立腦卒中模型,然后用孤養(yǎng)法加以CUMS制作PSD模型。對(duì)照組大鼠正常飼養(yǎng)。給予CUMS后第29天處死各組大鼠,取額葉、海馬、杏仁核區(qū)腦組織行神經(jīng)元特異性核蛋白(NeuN)免疫熒光組織染色,光鏡下計(jì)數(shù)并比較各組大鼠額葉、海馬、杏仁核中神經(jīng)元(NeuN陽(yáng)性細(xì)胞)的數(shù)量。結(jié)果 PSD組大鼠情感障礙相關(guān)腦區(qū)額葉、海馬、杏仁核中神經(jīng)元數(shù)量分別為(98.20±1.78)、(43.00±7.87)、(93.00±3.53)個(gè)/視野,均低于其他三組(P均0.05)。結(jié)論 PSD組大鼠情感障礙相關(guān)腦區(qū)額葉、海馬和杏仁核神經(jīng)元數(shù)量減少。
[Abstract]:Objective to observe the changes of neurons in frontal lobe, hippocampus and amygdala in affective disorder related brain regions of rats with poststroke depression (PSD). Methods Twenty healthy adult female SD rats were randomly divided into depression group, stroke group and control group with 5 rats in each group. Depression model was established in depression group with chronic unpredictable moderate stress stimulation (CUMS). The stroke model was established by thread embolization method in stroke group. The stroke model was established by thread embolization method in PSD group, and then PSD model was made by CUMS. Rats in the control group were fed normally. On the 29th day after CUMS, the rats in each group were killed. The brain tissues of frontal lobe, hippocampus and amygdaloid area were stained with neuron-specific nucleoprotein Neun. The frontal lobe and hippocampus of each group were counted and compared under light microscope. The number of Neun positive neurons in the amygdala. Results the number of neurons in the frontal lobe, hippocampus and amygdala in the PSD group was 98.20 鹵1.78 and 93.00 鹵3.53 respectively, which was lower than that in the other three groups (P < 0.05). Conclusion the number of neurons in frontal lobe, hippocampus and amygdala decreased in PSD group.
【作者單位】： 大理大學(xué)附屬醫(yī)院;大理大學(xué)臨床醫(yī)學(xué)院;
【基金】：國(guó)家自然科學(xué)基金資助項(xiàng)目(81360208)
【分類(lèi)號(hào)】：R743.3;R749.4

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