本文選題：注射用紅花黃色素　切入點(diǎn)：阿加曲班注射液　出處：《現(xiàn)代藥物與臨床》2016年02期

【摘要】：目的探討注射用紅花黃色素聯(lián)合阿加曲班治療急性腦梗死的臨床療效。方法選取2014年9月—2015年9月西安醫(yī)學(xué)院第二附屬醫(yī)院收治的急性腦梗死患者96例,依據(jù)不同治療方案分為治療組和對照組,每組各48例。所有患者均給予降低顱內(nèi)壓、營養(yǎng)神經(jīng)、調(diào)節(jié)血脂等基礎(chǔ)治療。對照組在此基礎(chǔ)上給予阿加曲班注射液,第1~2天,阿加曲班注射液60mg加入生理鹽水500 m L,24 h持續(xù)泵入;其后5 d,阿加曲班注射液10 mg加入生理鹽水100 m L,3 h持續(xù)泵入,2次/d,第8~14天,1次/d。治療組在對照組的基礎(chǔ)上滴注注射用紅花黃色素,100 m L/次,1次/d。兩組均連續(xù)治療2周。觀察兩組臨床療效,同時比較兩組神經(jīng)功能缺損量表(NIHSS)評分、Barthel指數(shù)、血液流變學(xué)指標(biāo)和血管內(nèi)皮功能及炎癥因子變化情況。結(jié)果治療后,對照組和治療組總有效率分別為77.08%、91.67%,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P0.05)。治療后,兩組血漿黏度、全血黏度、紅細(xì)胞壓積(HCT)以及紅細(xì)胞聚集指數(shù)(RF)均顯著降低,同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義(P0.05);且治療后治療組這些觀察指標(biāo)顯著低于對照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。治療后,兩組NIHSS評分均降低,Barthel指數(shù)均升高,同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義(P0.05);且治療2周后治療組這些觀察指標(biāo)顯著好于對照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。治療后,兩組一氧化氮(NO)、內(nèi)皮素-1(ET-1)、白細(xì)胞介素-8(IL-8)和腫瘤壞死因子α(TNF-α)表達(dá)水平均較治療前明顯改善,同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義(P0.05);且治療2周后治療組這些觀察指標(biāo)顯著好于對照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論注射用紅花黃色素聯(lián)合阿加曲班治療急性腦梗死具有較好的臨床療效,能明顯改善患者的血液流變學(xué)指標(biāo)和血管內(nèi)皮功能,具有一定的臨床推廣應(yīng)用價值。
[Abstract]:Objective to investigate the clinical effect of safflower yellow pigment combined with agaltreban for injection in the treatment of acute cerebral infarction.Methods 96 patients with acute cerebral infarction treated in the second affiliated Hospital of Xi'an Medical College from September 2014 to September 2015 were divided into treatment group (n = 48) and control group (n = 48).All patients were treated with basic treatment such as reducing intracranial pressure, nourishing nerves and regulating blood lipids.The control group was given Agatripine injection on this basis. On the 1st day of 2 days, 60mg was continuously pumped into the control group for 24 h with normal saline (500m L / L).After 5 days, 10 mg of agatoban injection was injected with 100 mL normal saline for 3 h and pumped continuously for 2 times per day, and once per day on day 814.On the basis of the control group, the treatment group was injected with safflower yellow pigment 100 mL / once a day.The two groups were treated continuously for 2 weeks.The clinical efficacy of the two groups was observed, and the changes of Barthel index, hemorheology index, vascular endothelial function and inflammatory factors were compared between the two groups.Results after treatment, the total effective rates of the control group and the treatment group were 77.08 and 91.67, respectively. The difference between the two groups was statistically significant (P 0.05).After treatment, plasma viscosity, whole blood viscosity, hematocrit HCT (HCT) and erythrocyte aggregation index (RFRF) of the two groups were significantly lower than those of the control group, and the difference between the two groups before and after treatment was statistically significant (P 0.05), and after treatment these indexes in the treatment group were significantly lower than those in the control group.The difference between the two groups was statistically significant (P 0.05).After treatment, the NIHSS scores of the two groups were significantly lower than those of the control group, and the difference between the two groups before and after treatment was statistically significant (P 0.05), and after 2 weeks of treatment, these indexes in the treatment group were significantly better than those in the control group, and the difference between the two groups was statistically significant.After treatment, the expression levels of nitric oxide, endothelin-1, interleukin-8 (IL-8) and tumor necrosis factor 偽 (TNF- 偽) in both groups were significantly improved compared with those before treatment.The difference before and after treatment in the same group was statistically significant (P 0.05), and the observation index in the treatment group was significantly better than that in the control group after 2 weeks of treatment, and the difference between the two groups was statistically significant (P 0.05).Conclusion the combination of safflower yellow and agatoban for injection has a good clinical effect on acute cerebral infarction. It can obviously improve the hemorheological index and vascular endothelial function of the patients, and has a certain clinical application value.
【作者單位】： 西安醫(yī)學(xué)院第二附屬醫(yī)院神經(jīng)內(nèi)科;
【分類號】：R743.3

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