本文選題：視神經(jīng)脊髓炎　切入點(diǎn)：水通道蛋白質(zhì)　出處：《中國(guó)現(xiàn)代神經(jīng)疾病雜志》2016年09期

【摘要】：目的基于2015年版視神經(jīng)脊髓炎譜系疾病診斷標(biāo)準(zhǔn),探討血清NMO-IgG陽(yáng)性和陰性患者臨床和影像學(xué)特征。方法回顧分析96例視神經(jīng)脊髓炎譜系疾病患者(包括NMO-IgG陽(yáng)性64例、NMO-Ig G陰性32例)的臨床和影像學(xué)表現(xiàn)。結(jié)果 NMO-IgG陽(yáng)性和陰性患者首次發(fā)病均以脊髓受累常見(jiàn),發(fā)生率分別為48.44%(31/64)和56.25%(18/32),其中感覺(jué)障礙(肢體麻木)發(fā)生率最高。NMO-IgG陽(yáng)性組首發(fā)視神經(jīng)受累癥狀以單側(cè)視力下降常見(jiàn)(12/16)、NMO-IgG陰性組以雙側(cè)視力下降常見(jiàn)(6/9),NMO-IgG陽(yáng)性組最后區(qū)受累的頑固性呃逆、嘔吐癥狀較NMO-IgG陰性組多見(jiàn)(11/18對(duì)2/7),組間差異均無(wú)統(tǒng)計(jì)學(xué)意義(P=0.087,0.202)。兩組患者首次發(fā)病時(shí)脊髓病灶均以頸髓常見(jiàn)[41.67%(15/36)和11/17],NMO-IgG陽(yáng)性組頸髓-胸髓連續(xù)病灶發(fā)生率[41.67%(15/36)對(duì)1/17]和病灶≥7個(gè)椎體節(jié)段比例[36.11%(13/36)對(duì)1/17]均高于NMO-Ig G陰性組(P=0.008,0.022),而顱內(nèi)病灶發(fā)生率[90.63%(29/32)對(duì)14/17]和延髓-頸髓連續(xù)病灶發(fā)生率(6/11對(duì)1/2)組間差異無(wú)統(tǒng)計(jì)學(xué)意義(P=0.702,1.000)。兩組患者病程中脊髓病灶發(fā)生率[84.38%(54/64)對(duì)84.38%(27/32)]、延髓-頸髓連續(xù)病灶發(fā)生率(9/19對(duì)3/6)和顱內(nèi)病灶發(fā)生率[86.54%(45/52)對(duì)83.33%(25/30)]差異均無(wú)統(tǒng)計(jì)學(xué)意義(P=1.000,1.000,0.934)。結(jié)論基于2015年版診斷標(biāo)準(zhǔn)分析我國(guó)血清NMO-IgG陽(yáng)性和陰性的視神經(jīng)脊髓炎譜系疾病患者的臨床和影像學(xué)特征,有助于進(jìn)一步提高疾病的診斷與治療水平。
[Abstract]:Objective based on the 2015 edition of the diagnostic criteria of optic neuromyelitis pedigree disease, To investigate the clinical and imaging features of serum NMO-IgG positive and negative patients. Methods the clinical and imaging features of 96 patients with optic neuromyelitis spectrum disease (including 64 NMO-IgG positive patients with NMO-Ig G negative) were retrospectively analyzed. Results NMO-IgG was performed. Spinal cord involvement is common in both positive and negative patients. The incidence rates were 48.4441 / 64) and 56.25m / 18 / 32, respectively. The incidence of sensory disorders (limb numbness) was the highest. The first onset of optic nerve involvement was unilateral visual acuity decline in 12 / 16 / 16 / NMO-IgG negative group, and 6 / 9NMO-IgG positive group had 6 / 9 / 9NMO-IgG positive group. Vomiting symptoms were 11 / 18 vs 2 / 7 in the NMO-IgG negative group, and there was no significant difference between the two groups. The cervical spinal cord lesions were common in the two groups at the first onset [41.675 / 36) and 11 / 17] NMO-IgG positive group, the incidence of continuous cervical and thoracic spinal cord lesions [41.67b 1536] and 鈮，

本文編號(hào)：1686065