本文選題：帕金森病　切入點：質(zhì)子磁共振波譜　出處：《磁共振成像》2016年05期

【摘要】：目的應用氫質(zhì)子磁共振波譜技術(shù)(1HMRS)檢測帕金森病(PD)患者腦部代謝物變化。材料與方法搜集PD患者42例、健康體檢者20例臨床資料,進行頭顱磁共振(MRI)和磁共振波譜(MRS)檢查,測定中腦黑質(zhì)、大腦蒼白球、前額葉、海馬區(qū)、楔回、背側(cè)丘腦的腦代謝物N-乙酰天冬氨酸/肌酸(NAA/Cr)、N-乙酰天冬氨酸/膽堿化合物(NAA/Cho)、膽堿化合物/肌酸(Cho/Cr)比值;比較兩組代謝物的差異性以及代謝物變化與UPDRS評分、病程的相關性。結(jié)果 (1)PD組NAA/Cr、NAA/Cho在雙側(cè)中腦黑質(zhì)、蒼白球、前額葉、海馬區(qū)、楔回、背側(cè)丘腦均顯著低于對照組(P0.01);Cho/Cr在右側(cè)海馬區(qū)、右側(cè)楔回、右背側(cè)丘腦均高于對照組(P0.05)。(2)PD組雙側(cè)黑質(zhì)(左r= 0.324,P=0.036,右r= 0.399,P=0.009)、右側(cè)蒼白球(r= 0.353,P=0.022)、左海馬區(qū)(r= 0.388,P=0.011)、左楔回(r= 0.325,P=0.036)NAA/Cho與UPDRS呈負相關(均P0.05);(3)左側(cè)蒼白球Cho/Cr比值與病程呈正相關(r=0.327,P=0.034)。結(jié)論 PD患者腦部存在廣泛神經(jīng)元損害伴有部分膠質(zhì)增生,腦代謝異常與臨床病情嚴重程度正相關,并隨病程的延長而逐漸加重。
[Abstract]:Objective to detect the changes of brain metabolites in patients with Parkinson's disease (PD) by hydrogen proton magnetic resonance spectroscopy (1H MRS). Materials and methods the clinical data of 42 PD patients and 20 healthy controls were collected, and the head magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) were performed. The ratio of N-acetylaspartic acid / creatine NAA / Na-acetylaspartic acid / choline compound (NAA / Cho), choline compound / creatine (Cho) was measured in the substantia nigra, globus pallidus, prefrontal lobe, hippocampal area, cuneate gyrus and dorsal thalamus. The differences of metabolites and their correlation with UPDRS score and course of disease were compared between the two groups. Results NAA / Cr 偽 NAA / Cho in bilateral midbrain substantia nigra, globus pallidus, prefrontal lobe, hippocampal area, wedged gyrus of PD group. The dorsal thalamus were significantly lower than those in the control group (P 0.01), and the right hippocampal area and the right cuneate gyrus were significantly lower than those in the control group. The bilateral substantia nigra (left r = 0.324g / P 0.036), the right (r = 0.399P) P ~ (0.009), the right globus pallidus (r = 0.353) (P ~ (0.022)), the left hippocampal area (r = 0.388P0.011), the left wedge gyrus (r = 0.325) ~ (0.036) NAA / Cho and UPDRS were negatively correlated with the course of disease in the right dorsal thalamus of PD group (all P 0.05). Conclusion there is a positive correlation between the Cho/Cr ratio of the left pallidus and the course of disease. Extensive neuronal damage associated with partial glial hyperplasia is present in PD patients. The abnormal brain metabolism was positively correlated with the severity of the disease, and gradually aggravated with the prolongation of the course of disease.
【作者單位】： 汕頭大學醫(yī)學院第二附屬醫(yī)院神經(jīng)內(nèi)科;汕頭大學醫(yī)學院第二附屬醫(yī)院影像科;
【基金】：汕頭大學醫(yī)學院臨床提升計劃科研基金項目(編號:201409)~~
【分類號】：R445.2;R742.5

【參考文獻】

相關期刊論文 前8條

1 方學文;胡濤;武玉華;黎見明;張安;胡炎興;周國華;沈君;;~1H-MRS檢測早期帕金森病紋狀體、黑質(zhì)的功能代謝[J];磁共振成像;2015年07期

2 彭帥;陳敏;李春媚;馬欣昕;婁寶輝;羅曉捷;王蕊;蘇聞;;帕金森病靜息態(tài)腦功能MRI研究[J];磁共振成像;2014年05期

3 張尤橋;楊忠現(xiàn);關計添;鄭曉紅;容宇;陳璇;洪標榮;陳薇;;代謝綜合征腦磁共振波譜和彌散張量成像的相關性研究[J];中國臨床神經(jīng)科學;2013年04期

4 邱喜雄;劉品霓;劉立紅;蔡曉東;杜立新;雷益;王佩萍;;質(zhì)子磁共振波譜在帕金森病患者紋狀體中的應用研究[J];深圳中西醫(yī)結(jié)合雜志;2011年04期

5 麻少輝;張明;Netra RANA;康蓓;劉麗華;屈秋民;;~1H-MRS觀察帕金森病患者延髓及黑質(zhì)代謝[J];中國醫(yī)學影像技術(shù);2011年01期

6 張莉;孔巖;徐，

本文編號：1678198