本文選題：嬰兒痙攣癥　切入點(diǎn)：免疫　出處：《中國(guó)當(dāng)代兒科雜志》2017年10期

【摘要】：目的通過(guò)檢測(cè)潑尼松治療嬰兒痙攣癥(IS)患兒前后的免疫功能,探討潑尼松治療IS的免疫機(jī)制。方法選取30例診斷為IS的患兒為IS組,30例行健康體檢嬰幼兒為健康對(duì)照組。采集IS組患兒經(jīng)潑尼松治療前后和健康對(duì)照組嬰幼兒的空腹靜脈血,采用化學(xué)發(fā)光法檢測(cè)血清IL-1B、IL-2R、IL-6、IL-8、TNF-α水平;免疫比濁法檢測(cè)血清免疫球蛋白IgA、IgM、IgG水平;流式細(xì)胞術(shù)檢測(cè)T細(xì)胞亞群(CD3~+、CD4~+、CD8~+)比例。潑尼松治療后對(duì)所有IS患兒進(jìn)行臨床療效和腦電圖評(píng)估。結(jié)果治療前IS組血清IL-2R、IL-8、TNF-α水平高于健康對(duì)照組(P0.05)。IS患兒平均每日發(fā)作串?dāng)?shù)分別與IL-2R、IL-8、TNF-α水平呈正相關(guān),平均每日發(fā)作總次數(shù)與IL-8水平呈正相關(guān),且IL-2R、IL-8、TNF-α水平兩兩間也呈正相關(guān)(P0.05)。30例IS患兒經(jīng)潑尼松治療后,19例發(fā)作控制,18例腦電圖高度失律完全緩解。治療后IS患兒每日發(fā)作串?dāng)?shù)及每日發(fā)作總次數(shù)均較治療前明顯下降,DQ值較治療前改善(P0.05);血清IL-2R、IL-8、TNF-α水平,以及CD4~+比例、CD4~+/CD8~+比值均較治療前明顯下降,CD8~+比例較治療前升高(P0.05)。結(jié)論 IS患兒存在免疫功能紊亂,潑尼松能控制IS患兒痙攣發(fā)作的效果可能與其可調(diào)節(jié)及改善IS患兒免疫紊亂有關(guān)。
[Abstract]:Objective to detect the immune function of prednisone before and after treatment of infantile spasticity (ISS). To explore the immunological mechanism of prednisone in the treatment of is, 30 children with is were selected as the healthy control group. The fasting venous blood was collected before and after prednisone treatment in the is group and the infants in the healthy control group before and after prednisone treatment. The levels of IL-1B, IL-2, IL-6 and IL-8 TNF- 偽 were detected by chemiluminescence assay, and the levels of serum IgA- IgM- 偽 were detected by immunoturbidimetric method, and the levels of IgM- 偽 and IgM- 偽 were determined by immunoturbidimetric assay. The percentage of T cell subsets CD3 ~ + CD4 ~ + CD8 ~) was detected by flow cytometry. The clinical efficacy and electroencephalogram (EEG) were evaluated after prednisone treatment. Results before treatment, the serum levels of IL-2RRnIL-8 / TNF- 偽 in the is group were higher than those in the healthy control group (P 0.05). The number of episode strings was positively correlated with the level of IL-8 and TNF- 偽, respectively. The average number of episodes per day was positively correlated with the level of IL-8. There was also a positive correlation between the two levels of IL-2R, IL-8 and TNF- 偽. 30 patients with is were treated with prednisone. After prednisone treatment, there were 19 patients with seizure control and 18 patients with complete remission of electroencephalogram (EEG) loss. After treatment, the number of episodes per day and the total number of episodes per day in the patients with is were significantly higher than those before treatment. Compared with before treatment, DQ was significantly decreased, and serum IL-2RnIL-8 / TNF- 偽 level was improved, and serum IL-2RU IL-8 / TNF- 偽 level was also improved compared with that before treatment. The ratio of CD4- / CD8- / CD4- / CD8- was significantly lower than that before treatment, and the ratio of CD8- / CD8- was significantly higher than that before treatment. Conclusion there is a disorder of immune function in children with is. The effect of prednisone on the control of spasmodic attack in children with is may be related to its adjustability and improvement of immune disorder in children with is.
【作者單位】： 江西省兒童醫(yī)院神經(jīng)內(nèi)科;
【基金】：江西省衛(wèi)生計(jì)生委課題(20161119)
【分類號(hào)】：R742.1

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本文編號(hào)：1677667