發(fā)布時間：2018-03-24 20:02

  本文選題：腦梗死　切入點：阿加曲班　出處：《臨床神經(jīng)病學(xué)雜志》2017年02期

【摘要】：目的觀察阿加曲班抗凝治療發(fā)病48 h內(nèi)的急性腦梗死的療效。方法收集2014年1月~2015年10月我院神經(jīng)內(nèi)科收治的發(fā)病48 h內(nèi)的急性腦梗死患者。根據(jù)是否使用阿加曲班治療分組,使用阿加曲班的患者入試驗組,未使用阿加曲班的患者入對照組。在治療前、后及病程14 d時進行NIHSS評分,病程6個月時進行mRS評分。比較兩組療效。結(jié)果本研究共計入組155例患者,試驗組107例,對照組48例。兩組患者年齡、性別、入院時血壓、NIHSS評分等差異均無統(tǒng)計學(xué)意義。試驗組NIHSS評分改善值明顯高于對照組,6個月時mRS評分明顯低于對照組(均P0.05)。對照組病程14 d時NIHSS評分明顯低于NIHSS評分峰值,試驗組病程14 d時NIHSS評分明顯低于入院時NIHSS評分和NIHSS評分峰值(均P0.05)。結(jié)論發(fā)病48 h內(nèi)的急性腦梗死患者采用阿加曲班抗凝治療療效和預(yù)后較好。
[Abstract]:Objective to observe the efficacy of Agatripine in the treatment of acute cerebral infarction within 48 hours after onset. Methods patients with acute cerebral infarction within 48 hours of onset were collected from January 2014 to October 2015. Patients with Agatripine were enrolled in the trial group, and those who did not received Agatripine were enrolled in the control group. The NIHSS scores were evaluated before, after treatment and at 14 days after the treatment. After 6 months of disease course, mRS score was used to compare the curative effect between the two groups. Results in this study, there were 155 patients in the study group, 107 patients in the trial group and 48 patients in the control group. There was no significant difference in the scores of blood pressure and NIHSS at admission. The improvement value of NIHSS score in the trial group was significantly higher than that in the control group, and the mRS score at 6 months was significantly lower than that in the control group (all P 0.05). The NIHSS score in the control group was significantly lower than the peak value of NIHSS score at 14 days after the course of disease. The NIHSS score at 14 days after the onset of disease in the trial group was significantly lower than the peak value of NIHSS score and NIHSS score at admission (all P 0.05). Conclusion Agatripine anticoagulant therapy is effective and prognostic in patients with acute cerebral infarction within 48 hours of onset.
【作者單位】： 南京醫(yī)科大學(xué)附屬蘇州醫(yī)院神經(jīng)內(nèi)科;
【分類號】：R743.33

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本文編號：1659817