本文選題：重度頸動(dòng)脈顱外段狹窄或閉塞　切入點(diǎn)：急性腦梗死　出處：《中風(fēng)與神經(jīng)疾病雜志》2016年02期

【摘要】：目的探討重度頸動(dòng)脈顱外段(ICA)狹窄或閉塞患者急性腦梗死的發(fā)病機(jī)制。方法采用CDFI或TCD篩選75例頸動(dòng)脈顱外段重度狹窄或閉塞導(dǎo)致的急性腦梗死患者,利用TCD檢測(cè)腦梗死患者顱內(nèi)血液動(dòng)力學(xué)變化,采用乳膠增強(qiáng)免疫比濁法測(cè)量hs-CRP水平,根據(jù)MRI定位對(duì)腦梗死模式進(jìn)行分類,分析頸動(dòng)脈顱外段重度狹窄或閉塞與腦梗死模式的關(guān)系;分析血清hs-CRP水平與頸動(dòng)脈不穩(wěn)定斑塊及腦梗死模式之間的相關(guān)性。結(jié)果 (1)區(qū)域梗死(Ⅰ型)和分水嶺梗死(Ⅴ型)發(fā)生率較高,頸動(dòng)脈顱外段重度狹窄或閉塞與腦梗死模式有關(guān)(P0.01)。(2)不穩(wěn)定斑塊組hs-CRP水平明顯高于穩(wěn)定斑塊組(P0.01),hs-CRP水平與腦梗死模式之間無相關(guān)性(P0.05)。結(jié)論 (1)重度頸動(dòng)脈顱外段狹窄的程度能影響腦梗死的模式,是急性腦梗死主要病因之一。(2)血清hs-CRP升高與腦梗死關(guān)系密切,是腦梗死的致病因子。
[Abstract]:Objective to investigate the pathogenesis of acute cerebral infarction in patients with severe stenosis or occlusion of extracranial carotid artery. Methods 75 patients with acute cerebral infarction caused by severe stenosis or occlusion of extracranial carotid artery were screened by CDFI or TCD. The changes of intracranial hemodynamics in patients with cerebral infarction were detected by TCD. The levels of hs-CRP were measured by latex enhanced immunoturbidimetry. The patterns of cerebral infarction were classified according to the location of MRI. To analyze the relationship between severe stenosis or occlusion of extracranial carotid artery and cerebral infarction model. The correlation between serum hs-CRP level and carotid artery unstable plaque and cerebral infarction pattern was analyzed. Results the incidence of regional infarction (type 鈪，

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