本文選題：高血壓腦出血　切入點：微創(chuàng)血腫清除術(shù)　出處：《山東醫(yī)藥》2017年12期 　論文類型：期刊論文

【摘要】：目的觀察醒腦靜注射液在高血壓腦出血患者微創(chuàng)血腫清除術(shù)后的應(yīng)用效果,并探討其機制。方法將108例急性高血壓腦出血患者隨機分為觀察組和對照組,每組54例。兩組均接受微創(chuàng)血腫清除術(shù)治療,術(shù)后接受常規(guī)康復(fù)治療。觀察組加用醒腦靜注射液靜滴,1次/d,共4周。比較兩組的臨床療效和治療前后神經(jīng)功能評分,檢測兩組治療前后血清超敏C反應(yīng)蛋白(hs-CRP)、TNF-α、IL-6。結(jié)果觀察組治療總有效率為94.4%,顯著高于對照組的72.2%(P0.05)。兩組治療后神經(jīng)功能評分較治療前均顯著下降,且觀察組顯著低于對照組(P均0.05)。兩組治療后血清TNF-α、IL-6和hs-CRP水平均較治療前顯著下降,且觀察組以上各指標均低于對照組(P均0.05)。結(jié)論高血壓腦出血患者微創(chuàng)血腫清除術(shù)后應(yīng)用醒腦靜注射液靜滴療效確切,能夠改善患者神經(jīng)功能,其機制可能與降低TNF-α、IL-6和hs-CRP水平有關(guān)。
[Abstract]:Objective to observe the effect of Xingnaojing injection on minimally invasive hematoma removal in patients with hypertensive intracerebral hemorrhage and to explore its mechanism. Methods 108 patients with acute hypertensive intracerebral hemorrhage were randomly divided into observation group and control group. 54 cases in each group were treated with minimally invasive hematoma clearance and routine rehabilitation after operation. The observation group was treated with Xingnaojing injection intravenously for 4 weeks. The clinical efficacy and neurological function score before and after treatment were compared. Results the total effective rate of the treatment group was 94.4, which was significantly higher than that of the control group (72.2%, P 0.05). After treatment, the neurological function score of the two groups was significantly lower than that of the control group. The serum levels of TNF- 偽 IL-6 and hs-CRP were significantly lower in the observation group than in the control group (P < 0.05), and the levels of TNF- 偽 IL-6 and hs-CRP in the two groups were significantly lower than those before the treatment. The above indexes in the observation group were lower than those in the control group (P < 0.05). Conclusion the effect of intravenous drip of Xingnaojing injection in patients with hypertensive intracerebral hemorrhage after minimally invasive hematoma removal is effective and can improve the neurological function of the patients. The mechanism may be related to the reduction of TNF- 偽 IL-6 and hs-CRP levels.
【作者單位】： 朝陽市中心醫(yī)院;
【分類號】：R743.34;R544.1

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1 趙衛(wèi)東;;微創(chuàng)血腫清除術(shù)治療高血壓腦出血92例[J];第四軍醫(yī)大學(xué)學(xué)報;2007年18期

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