本文選題：帕金森病　切入點(diǎn)：左旋多巴　出處：《福建醫(yī)科大學(xué)》2014年碩士論文　論文類(lèi)型：學(xué)位論文

【摘要】：目的：對(duì)長(zhǎng)期服用左旋多巴引起運(yùn)動(dòng)并發(fā)癥的PD患者進(jìn)行評(píng)估，試圖尋找與其相關(guān)的危險(xiǎn)因素，并結(jié)合國(guó)內(nèi)外已有的研究結(jié)果，分析相關(guān)因素的可能病理生理機(jī)制，以指導(dǎo)臨床上預(yù)防和減少運(yùn)動(dòng)并發(fā)癥的發(fā)生，提高PD患者的生活質(zhì)量。 方法：對(duì)94例門(mén)診確診的原發(fā)性PD病人進(jìn)行回顧性研究，收集內(nèi)容包括：年齡、性別、起病年齡、病程、左旋多巴使用情況、合并抗帕金森病用藥使用情況、吸煙、飲酒、喝茶、有毒物質(zhì)接觸史等生活習(xí)慣。所有數(shù)據(jù)使用SPSS21.0軟件進(jìn)行統(tǒng)計(jì)分析，采用t檢驗(yàn)、Mann-Whitney U非參數(shù)檢驗(yàn)、χ2檢驗(yàn)、Fisher確切概率法進(jìn)行組間差異比較；logistic回歸分析得出危險(xiǎn)因素；K-M生存曲線描述左旋多巴療程與運(yùn)動(dòng)并發(fā)癥發(fā)生的趨勢(shì)。 結(jié)果：組間差異比較中發(fā)病年齡、病程、左旋多巴療程、左旋多巴單日劑量、左旋多巴日均劑量、吸煙史與異動(dòng)癥的發(fā)生有關(guān)（P＜0.05）；病程、左旋多巴療程、左旋多巴單日劑量、左旋多巴日均劑量與癥狀波動(dòng)發(fā)生有關(guān)（P＜0.05）。異動(dòng)癥患者中低齡起病為獨(dú)立危險(xiǎn)因素；癥狀波動(dòng)患者中，病程及左旋多巴日均劑量為獨(dú)立危險(xiǎn)因素。 結(jié)論：我們的研究結(jié)果表明，發(fā)病年齡是異動(dòng)癥發(fā)生的獨(dú)立危險(xiǎn)因素，發(fā)病年齡越小，越容易發(fā)生異動(dòng)癥；病程和左旋多巴日均劑量是癥狀波動(dòng)發(fā)生的獨(dú)立危險(xiǎn)因素，病程越長(zhǎng)、左旋多巴治療劑量越大，越容易發(fā)生癥狀波動(dòng)；生存曲線提示左旋多巴療程長(zhǎng)會(huì)增加運(yùn)動(dòng)并發(fā)癥的發(fā)生率；控制癥狀、減少運(yùn)動(dòng)并發(fā)癥發(fā)生十分重要，避免或減少接觸危險(xiǎn)因素，可提高PD患者生活質(zhì)量，同時(shí)延長(zhǎng)生存時(shí)間。
[Abstract]:Objective: to evaluate the risk factors of PD patients who take levodopa for a long time and analyze the possible pathophysiological mechanism of the related factors. In order to guide clinical prevention and reduce the occurrence of sports complications, improve the quality of life of PD patients. Methods: a retrospective study was conducted on 94 patients with primary PD diagnosed in outpatient department. The data included age, sex, onset age, course of disease, use of levodopa, drug use of anti-Parkinson 's disease, smoking and drinking. Drinking tea, history of exposure to toxic substances and other habits. All data are analyzed using SPSS21.0 software. T test and 蠂 2 test were used to compare the difference between groups. Logistic regression analysis showed that the survival curve of K-M was used to describe the trend of levodopa treatment and sports complications. Results: the age of onset, course of disease, course of treatment of levodopa, daily dose of levodopa, daily average dose of levodopa, smoking history were related to the occurrence of ADHD (P < 0.05), course of disease, course of treatment of levodopa, daily dose of levodopa. The mean daily dose of levodopa was related to the occurrence of symptomatic fluctuation (P < 0.05). In patients with dyskinesia, the onset of early onset was an independent risk factor, and the course of disease and the daily average dose of levodopa were independent risk factors in patients with symptomatic fluctuation. Conclusion: the age of onset is an independent risk factor for the occurrence of dyskinesia, and the younger the onset age, the more likely it is to develop dyskinesia, the course of disease and the daily average dose of levodopa are independent risk factors for the occurrence of symptoms. The longer the course of disease, the greater the dosage of levodopa, the more prone to symptoms fluctuation; the survival curve indicates that the long course of treatment of levodopa will increase the incidence of sports complications; it is very important to control symptoms and reduce the occurrence of sports complications. To avoid or reduce exposure to risk factors can improve the quality of life and prolong the survival time of PD patients.
【學(xué)位授予單位】：福建醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類(lèi)號(hào)】：R742.5
，

本文編號(hào)：1619785