本文選題：顳葉癲癇　切入點(diǎn)：多通道腦電　出處：《天津醫(yī)科大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

【摘要】：研究目的： 癲癇是常見(jiàn)腦部疾病,對(duì)其發(fā)病機(jī)制的研究具有重要的臨床價(jià)值。本論文從多通道腦電的功能性連接和因果網(wǎng)絡(luò)的角度,以顳葉癲癇間歇期、發(fā)作前期、發(fā)作期和正常對(duì)照組的多通道腦電為研究對(duì)象,研究癲癇發(fā)作期過(guò)度放電的腦網(wǎng)絡(luò)機(jī)制,為癲癇機(jī)制研究提供思路和技術(shù)上的支持。 研究方法： 1實(shí)驗(yàn)數(shù)據(jù)：實(shí)驗(yàn)數(shù)據(jù)來(lái)自天津醫(yī)科大學(xué)總醫(yī)院神經(jīng)外科功能室,臨床確診的顳葉癲癇組(年齡在19歲至47歲),正常對(duì)照組(年齡在24歲至30歲)各8例。癲癇致癇灶均位于前顳區(qū)(頭皮電極F7、F8)。分別采集顳葉癲癇組間歇期、發(fā)作前期、發(fā)作期和正常對(duì)照組共4個(gè)組各10段,每段10秒的16通道腦電(EEGs)數(shù)據(jù)。 2數(shù)據(jù)預(yù)處理：對(duì)EEGs進(jìn)行去基線漂移和去工頻干擾,并應(yīng)用Matlab FastICA算法去除明顯偽跡。 3時(shí)頻分析：應(yīng)用短時(shí)傅里葉變換對(duì)EEGs逐一通道進(jìn)行時(shí)頻分析,研究能量最大通道的顳葉癲癇組間歇期、發(fā)作前期、發(fā)作期和正常對(duì)照組EEGs的時(shí)頻分析,從中獲取癲癇發(fā)作期的主要頻率范圍：6和θ。 4應(yīng)用帶通濾波獲取EEGs的δ和0頻段分量。 5分別對(duì)4個(gè)組每1段EEGs的6和0頻段分量進(jìn)行Granger頻域因果關(guān)系分析： (1)對(duì)16通道EEGs時(shí)間序列進(jìn)行頻域因果分析,計(jì)算兩個(gè)節(jié)點(diǎn)之間因果值γij,平均后得到定向傳遞函數(shù)(Directed Transfer Function, DTF)值。 (2)應(yīng)用γij構(gòu)建因果網(wǎng)絡(luò),計(jì)算網(wǎng)絡(luò)的BC度量值(Betweenness Centrality,BC)。 (3)BC值的K均值聚類分析： 對(duì)顳葉癲癇組間歇期、發(fā)作前期、發(fā)作期整個(gè)過(guò)程的BC度量值進(jìn)行K均值聚類分析,將網(wǎng)絡(luò)各個(gè)節(jié)點(diǎn)分成兩類：活躍節(jié)點(diǎn)和不活躍節(jié)點(diǎn),并且分別分析BC度量值的變化趨勢(shì)；以及對(duì)發(fā)作期的BC度量值進(jìn)行K均值聚類分析。 (4)計(jì)算發(fā)作期網(wǎng)絡(luò)的因果密度(Causal Density, CD): 計(jì)算顳葉癲癇組發(fā)作期各個(gè)節(jié)點(diǎn)的因果密度值,并對(duì)因果密度值進(jìn)行K均值聚類分析,和發(fā)作期BC度量值的活躍節(jié)點(diǎn)比較。 (5)計(jì)算網(wǎng)絡(luò)的因果流(Causal Flow, CF): 計(jì)算發(fā)作期活躍節(jié)點(diǎn)和非活躍節(jié)點(diǎn)的因果流值,以及間歇期、發(fā)作前期與活躍節(jié)點(diǎn)相對(duì)應(yīng)節(jié)點(diǎn)的因果流值并比較分析。 研究結(jié)果： 1時(shí)頻分布：為顳葉癲癇發(fā)作期能量集中在低頻段：δ和0頻段。 24個(gè)組多通道腦電的頻域功能性連接 (1)6頻段： 顳葉癲癇組：間歇期DTF均值(7.3404±1.9629)；發(fā)作前期DTF均值(4.8755±1.0541)；發(fā)作期DTF均值(8.1770±1.6978)。 正常對(duì)照組DTF均值(2.1591±0.5561)。 (2)θ頻段： 顳葉癲癇組：間歇期DTF值(8.1263±0.4356)；發(fā)作前期DTF值(3.5955±0.8756)；發(fā)作期DTF值(8.2826±0.4899)。 正常對(duì)照組DTF值(2.7373±0.6542)。 3顳葉癲癇組間歇期、發(fā)作前期和發(fā)作期BC度量值K均值聚類分析 (1)6頻段活躍節(jié)點(diǎn),間歇期BC度量值(0.0499±0.0149)；發(fā)作前期BC度量值(0.0469±0.0095)；發(fā)作期BC度量值(0.0800±0.0200)。 (2)0頻段活躍節(jié)點(diǎn),間歇期BC度量值(0.0467±0.0108)；發(fā)作前期BC度量值(0.0437±0.0076)；發(fā)作期BC度量值(0.0651±0.0126)。 4顳葉癲癇組發(fā)作期BC度量值與CD值的K均值聚類分析比較 在δ和0各個(gè)頻段,BC度量值的活躍節(jié)點(diǎn)和CD值的活躍節(jié)點(diǎn)重合率很高,兩者相同,或者前者包括了后者,或者后者包括了前者；兩者的位置與致癇灶位置并不相符。 5顳葉癲癇組發(fā)作期活躍節(jié)點(diǎn)的因果流分析 (1)δ頻段發(fā)作期活躍節(jié)點(diǎn)CF值(0.6864±0.3037),間歇期、發(fā)作前期與活躍節(jié)點(diǎn)相對(duì)應(yīng)的區(qū)域CF值(0.1495±0.1358)、(0.1174±0.0648)經(jīng)過(guò)驗(yàn)證皆符合正態(tài)分布,發(fā)作期活躍節(jié)點(diǎn)CF值分別與間歇期、發(fā)作前期相對(duì)應(yīng)的區(qū)域CF值進(jìn)行t檢驗(yàn),p0.05,均有顯著性差異。 (2)0頻段發(fā)作期活躍節(jié)點(diǎn)CF值(0.6661±0.1645),間歇期、發(fā)作前期與活躍節(jié)點(diǎn)相對(duì)應(yīng)的區(qū)域CF值(0.0774±0.1973)、CF值(0.1489±0.0570),經(jīng)過(guò)驗(yàn)證皆符合正態(tài)分布,發(fā)作期活躍節(jié)點(diǎn)CF值分別與間歇期、發(fā)作前期相對(duì)應(yīng)的區(qū)域CF值進(jìn)行t檢驗(yàn),p0.05,均有顯著性差異。 結(jié)論： 1顳葉癲癇發(fā)作期能量集中頻帶為δ和0頻段。 2顳葉癲癇組發(fā)作期比間歇期、發(fā)作前期功能連接特性增強(qiáng)；發(fā)作期比正常對(duì)照組功能連接特性增強(qiáng)；間歇期和發(fā)作前期功能連接性無(wú)明顯差異；間歇期、發(fā)作間期比正常對(duì)照組功能連接特性增強(qiáng)。 3顳葉癲癇發(fā)作期活躍節(jié)點(diǎn)因果網(wǎng)絡(luò)的BC度量值比間歇期、發(fā)作前期增大,間歇期和發(fā)作前期BC度量值無(wú)明顯差異。 4顳葉癲癇發(fā)作期根據(jù)因果密度和BC度量值分別K均值聚類分析得到的活躍節(jié)點(diǎn)位置相近。 5顳葉癲癇發(fā)作期活躍節(jié)點(diǎn)因果流值較大屬于因果源；非活躍節(jié)點(diǎn)因果流值較小屬于因果匯。
[Abstract]:The purpose of the study is:
Epilepsy is a common disease of the brain, the research on the pathogenesis of this disease has important clinical value. This paper from the function of multi-channel connection and causal network perspective, with intermittent temporal lobe epilepsy, early attack, attack of multi-channel EEG and normal control group as the research object, the mechanism of brain network excessive discharge of epileptic seizures, provide ideas and technical support for the mechanism of epilepsy.
Research methods:
1 experimental data: the experimental data from the Department of Neurosurgery of General Hospital Affiliated to Tianjin Medical University function room, clinical diagnosis of temporal lobe epilepsy group (aged 19 to 47 years old), normal control group (aged 24 to 30 years). All 8 cases of epileptogenic focus were located in the anterior temporal region (scalp electrodes F7, F8) were collected. Period of intermittent temporal lobe epilepsy pre ictal and normal control group 4 group 10, 16 channel EEG every 10 seconds (EEGs) data.
2 data preprocessing: baseline drift and power frequency interference to EEGs, and Matlab FastICA algorithm to remove obvious artifacts.
3 time frequency analysis of EEGs: one by one channel based on short time Fourier transform time-frequency analysis, temporal lobe epilepsy group of intermittent period, maximum energy channel before the attack, attack analysis and control group when the frequency of EEGs, get the main frequency range of seizure period from 6 and 0.
4 the band pass filter is used to obtain the Delta and 0 band components of EEGs.
5 the Granger frequency domain causality analysis of the 6 and 0 band components of each 1 segments of EEGs in 4 groups was analyzed, respectively.
(1) frequency domain causality analysis for 16 channel EEGs time series. We calculate the causal value ij between two nodes, and get the Directed Transfer Function (DTF) value after averaging.
(2) the causality network is constructed with gamma ij, and the BC measurement value (Betweenness Centrality, BC) of the network is calculated.
(3) K mean clustering analysis of BC value:
The temporal lobe epilepsy group intermittent period, early attack, attack the whole process of the BC measure of K clustering, every node in the network will be divided into two categories: active and inactive node node, and the variation trend of the BC value respectively; and to attack the BC measure of K clustering analysis.
(4) calculate the causality density (Causal Density, CD) of the attack network:
The causal density values of each node in the temporal lobe epilepsy group were calculated, and the K density clustering analysis of the causal density values was compared with the active nodes in the BC period.
(5) computing network causality flow (Causal Flow, CF):
The causal flow values of active nodes and inactive nodes in the attack phase are calculated, and the causal flow values corresponding to the nodes in the early stage and the active nodes are compared and analyzed.
The results of the study:
1 time frequency distribution: the energy of the temporal lobe epilepsy is concentrated at low frequency segments: Delta and 0 frequency bands.
Frequency domain functional connection of 24 groups of multichannel EEG
(1) 6 frequency bands:
Temporal lobe epilepsy group: DTF mean (7.3404 + 1.9629) in intermission, DTF mean (4.8755 + 1.0541) in pre attack, and DTF mean (8.1770 + 1.6978) at attack stage.
The mean value of DTF in the normal control group was (2.1591 + 0.5561).
(2) frequency band:
Temporal lobe epilepsy group: DTF value in intermission (8.1263 + 0.4356), DTF value (3.5955 + 0.8756) in pre attack and DTF (8.2826 + 0.4899) at attack stage.
The value of DTF in the normal control group was (2.7373 + 0.6542).
3 temporal lobe epilepsy group intermission, K mean cluster analysis of BC measurement at prophase and episodes
(1) active node in 6 frequency band, BC measure (0.0499 + 0.0149) in intermittent period, BC measure (0.0469 + 0.0095) in pre attack, and BC measure (0.0800 + 0.0200) at attack stage.
(2) active node in 0 frequency band, BC measure (0.0467 + 0.0108) in intermittent period, BC measure (0.0437 + 0.0076) in pre attack, and BC measure (0.0651 + 0.0126) at attack stage.
Comparison of BC and CD values of temporal lobe epilepsy group in 4 temporal lobe epilepsy group by K mean cluster analysis
In every band of delta and 0, the coincidence rate of active nodes and active nodes of BC value is very high. The coincidence rate between them is the same, or the former includes the latter, or the latter includes the former; the location of the CD is not consistent with the location of epileptogenic foci.
Causality flow analysis of active nodes in the 5 temporal lobe epilepsy group
(1) delta band ictal active node CF values (0.6864 + 0.3037), intermittent period, regional CF early attack and active node value corresponding to (0.1495 + 0.1358), (0.1174 + 0.0648) were tested with normal distribution, exacerbation of active node CF respectively and intermittent period, hair area the CF value corresponding to the t test, P0.05, there were significant differences.
(2) 0 band ictal active node CF values (0.6661 + 0.1645), intermittent period, regional CF early attack and active node value corresponding to (0.0774 + 0.1973), CF (0.1489 + 0.0570), after verification with normal distribution, exacerbation of active node CF respectively and intermittent period, attack region pre CF value corresponding to the t test, P0.05, there were significant differences.
Conclusion:
1 the energy concentration band of temporal lobe epilepsy is delta and 0 frequency bands.
2 temporal lobe epilepsy onset period than the intermittent period, connecting the characteristics to enhance the early attack; attack than the normal control group functional connectivity enhancements; intermittent period and early attack functional connectivity had no significant difference; intermittent period, interictal than the normal control group the function of connection characteristics increase.
3 the BC measurement values of active node causality network in temporal lobe epilepsy were more than that in the intermission period, the pre attack increased, and there was no significant difference in the BC measurement between the intermittent period and the pre attack stage.
4 the active nodes of temporal lobe epilepsy are similar to the active nodes according to the K mean clustering analysis of the causal density and the BC measure respectively.
5 the causality flow value of active node in temporal lobe epilepsy is larger than that of causality, and the value of causality flow of non active node is smaller than that of causality.

【學(xué)位授予單位】：天津醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R742.1

【共引文獻(xiàn)】

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