本文選題：膠質(zhì)瘤　切入點(diǎn)：動(dòng)態(tài)對(duì)比增強(qiáng)　出處：《中國(guó)醫(yī)學(xué)計(jì)算機(jī)成像雜志》2017年04期 　論文類型：期刊論文

【摘要】：目的:通過(guò)對(duì)腦膠質(zhì)瘤患者進(jìn)行動(dòng)態(tài)對(duì)比增強(qiáng)磁共振成像(DCE-MRI)獲得容積轉(zhuǎn)運(yùn)參數(shù)(Ktrans)與血管外細(xì)胞外間隙容積比(Ve),探討DCE-MRI定量評(píng)估膠質(zhì)瘤不成熟微血管密度的價(jià)值。方法:研究對(duì)象包括66例腦膠質(zhì)瘤患者,其中Ⅱ級(jí)27例,Ⅲ級(jí)8例,Ⅳ級(jí)31例。每名腦膠質(zhì)瘤患者術(shù)前經(jīng)過(guò)DCE-MRI檢查獲得膠質(zhì)瘤的Ktrans與Ve的最大值,術(shù)后膠質(zhì)瘤標(biāo)本進(jìn)行免疫組織化學(xué)測(cè)量CD105陽(yáng)性標(biāo)記的微血管密度(CD105-MVD)的最大值。應(yīng)用Mann-Whitney U檢驗(yàn)比較不同級(jí)別膠質(zhì)瘤Ktrans值、Ve值、CD105-MVD的差異,應(yīng)用Pearman相關(guān)系數(shù)分析膠質(zhì)瘤Ktrans值、Ve值與CD105-MVD的相關(guān)性。結(jié)果:低級(jí)別膠質(zhì)瘤的Ktrans值、Ve值、CD105-MVD均小于高級(jí)別膠質(zhì)瘤(P0.001,P0.001,P0.001)。高級(jí)別膠質(zhì)瘤的Ktrans值、Ve值均與CD105-MVD正相關(guān)(P0.001,P0.001)。結(jié)論:DCE-MRI可以定量評(píng)估腦膠質(zhì)瘤不成熟微血管密度。
[Abstract]:Objective: to evaluate the value of DCE-MRI in quantitative evaluation of immature microvessel density of gliomas by dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) and extracellular space volume ratio (ECV) obtained by dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). Methods: 66 patients with glioma were included in the study. There were 27 cases of grade 鈪，

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