本文關(guān)鍵詞： 抗γ-氨基丁酸B型受體 邊緣性腦炎 癲癇　出處：《廣西醫(yī)科大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:探討抗γ-氨基丁酸B型受體(γ-aminobutyric acid-B receptor,GABABR)腦炎的臨床特點(diǎn)及治療方案。方法:回顧性分析3例抗GABABR腦炎患者的臨床資料并結(jié)合國內(nèi)外文獻(xiàn)進(jìn)行綜合分析。結(jié)果:3例抗GABABR腦炎患者均以亞急性起病,2例以抽搐、1例以頭痛、發(fā)熱為首發(fā)癥狀;3例均有精神行為異常、記憶力下降、抽搐癥狀;2例顱腦MRI顯示邊緣系統(tǒng)長T2信號,FLAIR呈高信號,3例腦電圖均有不同程度異常;1例發(fā)病前有子宮頸癌病史;1例免疫治療后癥狀完全緩解,1例抗病毒治療后癥狀有所改善。結(jié)論:抗GABABR腦炎的主要臨床表現(xiàn)為精神行為異常、記憶力下降和癲癇發(fā)作,顱腦MRI可見顳葉內(nèi)側(cè)或海馬異常信號影,但臨床表現(xiàn)和影像學(xué)特點(diǎn)缺乏特異性,且與“病毒性腦炎”相似,臨床上易漏診、誤診,故對疑是患者應(yīng)盡早完善GABABR抗體篩查。該病對免疫治療敏感,提高該病的認(rèn)識和早期診斷、早期治療尤為重要。
[Abstract]:Objective: To evaluate the efficacy of gamma aminobutyric acid type B receptor (gamma -aminobutyric acid-B receptor, GABABR) the clinical characteristics and treatment of encephalitis. Methods: a retrospective analysis of 3 patients with anti GABABR encephalitis in patients with clinical data were analyzed with literature. Results: 3 cases of anti GABABR encephalitis patients with subacute onset. 2 cases with convulsions, 1 cases with headache, fever as the first symptom; 3 cases had abnormal mental behavior, memory loss, convulsive symptoms; 2 cases of brain MRI showed that the long edge of the T2 signal system, FLAIR showed high signal, 3 cases had different degrees of abnormal EEG; 1 cases had a history of cervical cancer before the disease; 1 cases of immunotherapy after complete remission of symptoms, the symptoms improved after antiviral treatment in 1 cases. Conclusion: the main clinical anti GABABR encephalitis is manifested as mental behavior, memory loss and seizures, brain MRI or medial temporal lobe hippocampus shows abnormal signal, but The clinical manifestation and imaging features are lack of specificity, and "viral encephalitis" similar to clinical misdiagnosis, missed diagnosis, the suspected patients should as soon as possible to improve GABABR antibody screening. The disease is sensitive to immunotherapy, increased awareness and early diagnosis of the disease, early treatment is very important.

【學(xué)位授予單位】：廣西醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R742.9

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