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  本文關(guān)鍵詞： 飲酒量 急性腦梗死 尿酸 血脂 胰島素抵抗　出處：《延邊大學》2016年碩士論文　論文類型：學位論文

【摘要】：目的檢測男性急性腦梗死(缺血性腦卒中)患者血清尿酸、血脂水平,探討不同飲酒量對血清尿酸水平的影響及尿酸與血脂的相關(guān)性。方法選取延邊大學附屬醫(yī)院2015年2月-2016年1月診斷為急性腦梗死的279例住院男性患者作為研究對象,平均年齡為58.31±8.52歲。根據(jù)飲酒量不同分為不飲酒組、少量飲酒組、中量飲酒組、過量飲酒組。所有患者中尿酸420μmol/L者組成高尿酸血癥組(35例),其余患者組成尿酸正常組(244例)。測定血清尿酸(UA)、甘油三酯(TG)、總膽固醇(TC)、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇(HDL-C)等,并計算TG/HDL-C,評價飲酒量與血尿酸之間的關(guān)系以及血尿酸與TG、TC、HDL-C、LDL-C、TG/HDL-C的相關(guān)性。結(jié)果1.不飲酒組、少量飲酒組、中量飲酒組、過量飲酒組之間,年齡、體重指數(shù)、高血壓病史、糖尿病病史、NIHSS評分差異無統(tǒng)計學意義(P0.05)。不同飲酒量組間吸煙史差異有統(tǒng)計學意義(P0.05)；少量飲酒組、大量飲酒組的吸煙史顯著高于不飲酒組(P0.05)；少量飲酒組、中量飲酒組、大量飲酒組的吸煙史無顯著性差異(P0.05)。2.不同飲酒量組間UA水平差異有統(tǒng)計學意義(P0.05)。大量飲酒組的尿酸水平高于少量及中量飲酒組的尿酸水平,差異有統(tǒng)計學意義(P0.05)；大量飲酒組的尿酸水平高于不飲酒組的尿酸水平,但差異無統(tǒng)計學意義(P0.05)。3.高尿酸血癥組與尿酸正常組的年齡、BMI、高血壓病史、糖尿病病史、吸煙史、飲酒量、NIHSS評分之間的差異均無統(tǒng)計學意義(P0.05)4.高尿酸血癥組的TC、TG、LDL-C、TG/HDL-C高于尿酸正常組,差異有統(tǒng)計學意義(P0.05)。高尿酸血癥組的HDL-C水平低于尿酸正常組的HDL-C水平,但差異無統(tǒng)計學意義(P0.05)。5. UA與TC、TG、LDL-C、HDL-C、TG/HDL-C的相關(guān)系數(shù)分別為0.219、0.264、0.132、-0.075、0.238、其中與TC, TG, LDL-C, TG/HDL-C呈顯著正相關(guān)(P0.05)。結(jié)論1.在男性急性腦梗死患者中,飲酒量與血清尿酸水平密切相關(guān),與少到中量飲酒相比,大量飲酒可導致尿酸水平升高。2.在男性急性腦梗死患者中,尿酸與血脂代謝、胰島素抵抗密切相關(guān)。3.在男性急性腦梗死患者中,尿酸與TC、TG、LDL-C、TG/HDL-C呈正相關(guān)。
[Abstract]:Objective to detect the levels of serum uric acid and blood lipid in male patients with acute cerebral infarction. To explore the effect of alcohol intake on serum uric acid level and the correlation between uric acid and blood lipids. Methods 279 hospitalized male patients diagnosed as acute cerebral infarction from February 2015 to January 2016 in Yanbian University Hospital were selected as the study objects. The average age was 58.31 鹵8.52 years old. All patients were divided into hyperuricemia group (n = 35) and control group (n = 244). Serum uric acid, triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density (HDLC) were measured. Lipoprotein cholesterol, HDL-C, etc. To evaluate the relationship between alcohol consumption and serum uric acid, and the correlation between serum uric acid and TGG / HDL-C, the results were as follows: 1. Age, body mass index, hypertension history, age, age, body mass index, and history of hypertension were calculated in non-alcohol drinking group, moderate alcohol drinking group, moderate alcohol drinking group, moderate drinking group, moderate drinking group, and moderate alcohol drinking group, as well as the correlation between serum uric acid and TGG / HDL-C. There was no significant difference in NIHSS score of diabetes mellitus history (P 0.05). There was a significant difference in smoking history among different alcohol consumption groups (P 0.05); the smoking history of heavy drinking group was significantly higher than that of non-alcohol drinking group (P 0.05); the smoking history of low alcohol drinking group was significantly higher than that of non-alcohol drinking group, while that of moderate alcohol drinking group was lower than that of moderate alcohol drinking group. There was no significant difference in smoking history in heavy drinking group (P 0.05). There was significant difference in UA level among different drinking groups (P 0.05). The uric acid level in heavy drinking group was higher than that in small and moderate drinking group. The level of uric acid in the heavy drinking group was higher than that in the non-drinking group, but there was no significant difference in the level of uric acid between the hyperuricemia group and the normal uric acid group. The age of BMIs, the history of hypertension, the history of diabetes, and the history of smoking in hyperuricemia group were significantly higher than those in non-drinking group, but there was no significant difference in the level of uric acid between hyperuricemia group and normal uric acid group. There was no significant difference in NIHSS score between the two groups. The levels of HDL-C in hyperuricemia group were significantly higher than those in normal uric acid group, and the HDL-C level in hyperuricemia group was lower than that in normal uric acid group. But there was no significant difference (P 0.05). The correlation coefficient between UA and serum uric acid level was 0.21919 ~ 0.264 ~ 0.262 ~ (-0.075) ~ 0.238, respectively, and there was a significant positive correlation between serum uric acid level and alcohol consumption in male patients with acute cerebral infarction. Conclusion (1) in male patients with acute cerebral infarction, alcohol consumption is closely related to serum uric acid level, compared with moderate to moderate alcohol consumption, and there is a significant positive correlation between serum uric acid level and serum uric acid level in male patients with acute cerebral infarction, and there is a significant positive correlation between UA and LDL-C and TG/HDL-C in male patients with acute cerebral infarction, compared with moderate to moderate alcohol consumption, there is a significant correlation between alcohol consumption and serum uric acid level in male patients with acute cerebral infarction. 2. In male patients with acute cerebral infarction, uric acid was closely related to blood lipid metabolism and insulin resistance. In male patients with acute cerebral infarction, uric acid was positively correlated with TGLDL-C TG- / HDL-C.
【學位授予單位】：延邊大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R743.3

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