本文關(guān)鍵詞： 腦梗死 不穩(wěn)定斑塊 頸動(dòng)脈彩超 超敏C反應(yīng)蛋白 內(nèi)中膜厚度　出處：《安徽醫(yī)科大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

【摘要】：目的： 聯(lián)合頸動(dòng)脈彩超及超敏C反應(yīng)蛋白(high-sensitive C-reactive protein, hs-CRP)檢測(cè)，探討兩者在動(dòng)脈粥樣硬化腦梗死中的臨床應(yīng)用價(jià)值。 方法： 收集83例安徽省立醫(yī)院神經(jīng)內(nèi)科急性動(dòng)脈粥樣硬化腦梗死患者（男性47例，女性36例）為實(shí)驗(yàn)組，50例我院同期健康體檢者（男性28例，女性22例）為對(duì)照組。分別對(duì)腦梗死組與對(duì)照組進(jìn)行頸動(dòng)脈彩超及hs-CRP檢測(cè)，詳細(xì)記錄兩組頸動(dòng)脈有無斑塊、斑塊性質(zhì)和內(nèi)-中膜厚度(Intima-media thickness, IMT)，并對(duì)其與腦梗死之間的關(guān)系進(jìn)行比較和分析；對(duì)腦梗死患者進(jìn)行NIHSS評(píng)分，比較分析不同程度神經(jīng)功能障礙患者間IMT及hs-CRP水平的差異。 結(jié)果： 1．腦梗死組斑塊檢出率、IMT及hs-CRP水平明顯高于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P均0.05）； 2．不穩(wěn)定斑塊組hs-CRP、IMT水平及同側(cè)腦梗死發(fā)生率均高于穩(wěn)定斑塊組，差異有統(tǒng)計(jì)學(xué)意義（P均0.05）； 3．hs-CRP水平與IMT成正相關(guān)（r=0.67，P0.05）。 4．hs-CRP水平與臨床神經(jīng)功能缺損評(píng)分成正相關(guān)（r=0.58，P0.05）。 結(jié)論： 1．頸動(dòng)脈粥樣硬化不穩(wěn)定斑塊與腦梗死發(fā)生密切相關(guān)。 2．IMT與動(dòng)脈粥樣硬化及卒中風(fēng)險(xiǎn)密切相關(guān)，，超聲測(cè)量頸動(dòng)脈IMT增厚是一種可靠的評(píng)估動(dòng)脈粥樣硬化的無創(chuàng)性指標(biāo)。 3．hs-CRP水平升高可增加頸動(dòng)脈斑塊不穩(wěn)定性，并可反映神經(jīng)功能損害程度。4．結(jié)合頸動(dòng)脈彩超及hs-CRP檢測(cè)有助于指導(dǎo)腦梗死的臨床治療和評(píng)估預(yù)后。
[Abstract]:Objective: Combined with carotid color Doppler ultrasound and high-sensitive C-reactive protein (hs-CRP), high-sensitive C-reactive protein (hs-CRP) was detected. To explore the clinical application value of both in atherosclerotic cerebral infarction. Methods: A total of 83 patients (47 males and 36 females) with acute atherosclerotic cerebral infarction (ACI) in Department of Neurology, Anhui Provincial Hospital, were selected as experimental group (n = 50, male 28). Carotid ultrasound and hs-CRP were performed in the cerebral infarction group and the control group respectively. The carotid plaques in both groups were recorded in detail. The characteristics of plaque and intima-media thickness. IMTT were compared and analyzed. The NIHSS scores of patients with cerebral infarction were evaluated and the differences of IMT and hs-CRP levels among patients with different degrees of neurological dysfunction were compared. Results: 1. The levels of IMT and hs-CRP in cerebral infarction group were significantly higher than those in control group (P < 0.05). 2. The level of hs-CRP IMT and the incidence of ipsilateral cerebral infarction in unstable plaque group were higher than those in stable plaque group (P < 0.05). 3. There was a positive correlation between hs-CRP level and IMT. 4. There was a positive correlation between hs-CRP level and clinical neurological impairment score (P 0.05). Conclusion: 1. The unstable plaque of carotid atherosclerosis is closely related to the occurrence of cerebral infarction. 2. IMT was closely associated with atherosclerosis and stroke risk. Measurement of carotid IMT thickening by ultrasound is a reliable noninvasive index for assessing atherosclerosis. 3. Increased levels of hs-CRP increased carotid plaque instability. Combined with carotid color ultrasound and hs-CRP, it is helpful to guide the clinical treatment and evaluate the prognosis of cerebral infarction.
【學(xué)位授予單位】：安徽醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R743.33;R543.4

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 趙世華;;易損斑塊的含義和診斷標(biāo)準(zhǔn)[J];磁共振成像;2010年06期

2 瞿萍;夏蘭;陳貴海;;炎癥與腦梗死患者頸動(dòng)脈粥樣硬化關(guān)系的臨床研究[J];河北醫(yī)藥;2010年13期

3 祁永康;徐娟;陳文強(qiáng);;可溶性細(xì)胞黏附分子及頸動(dòng)脈斑塊性質(zhì)與缺血性腦卒中關(guān)系的臨床研究[J];臨床薈萃;2010年24期

4 王慧梅;李淮玉;;頸動(dòng)脈易損斑塊的臨床特征及其與缺血性卒中關(guān)系的研究進(jìn)展[J];中國腦血管病雜志;2012年05期

5 高明;李冬青;臧書梅;朱辰蕊;李金鋒;劉英;趙洪濤;王艷秀;王艷麗;;代謝綜合征與頸動(dòng)脈內(nèi)中膜厚度的相關(guān)性研究[J];河北醫(yī)藥;2013年06期

6 劉月英;畢國榮;;頸動(dòng)脈粥樣硬化及hs-CRP與急性腦梗塞的臨床關(guān)系[J];中國熱帶醫(yī)學(xué);2008年10期

7 張淑敏;陳淑慧;劉敏;孔斌;竇萍;;頸動(dòng)脈粥樣斑塊穩(wěn)定性及血清超敏C反應(yīng)蛋白與急性腦梗死發(fā)病機(jī)制關(guān)系的研究[J];山西醫(yī)藥雜志;2010年06期

8 張琳;董亞茹;;腦梗死與頸動(dòng)脈粥樣硬化相關(guān)性研究[J];陜西醫(yī)學(xué)雜志;2009年11期

9 劉軍;陳新軍;吳小花;;血漿基質(zhì)金屬蛋白酶-2、9與腦梗死的相關(guān)性研究[J];陜西醫(yī)學(xué)雜志;2010年10期

10 梁容仙;廖仁昊;胡偉東;;急性腦梗死患者氧化低密度脂蛋白、高敏C-反應(yīng)蛋白含量變化的研究[J];現(xiàn)代預(yù)防醫(yī)學(xué);2008年02期

本文編號(hào)：1490257