本文關鍵詞： 腦梗死 短暫性腦缺血發(fā)作 炎癥因子　出處：《國際神經(jīng)病學神經(jīng)外科學雜志》2017年03期 　論文類型：期刊論文

【摘要】：目的探討不同炎癥因子在腦梗死與短暫性腦缺血發(fā)作患者的表達情況。方法選取64例短暫性腦缺血發(fā)作患者(TIA組)、58例腦梗死患者(CI組)以及50例健康人員(NC組),分析并統(tǒng)計3組受試對象炎癥因子表達情況。結果 CI組MMP-9(83.14±9.27)μg/L、NF-κB(36.88±6.27)%、IL-33(71.63±4.83)ng/m L及hs-CRP(12.57±1.29)mg/L,TIA組分別為(29.17±4.54)μg/L、NF-κB(31.20±5.97)%、IL-33(104.59±8.27)ng/m L及hs-CRP(6.23±1.04)mg/L,兩組間比較差異具有統(tǒng)計學意義(P=0.026、P=0.032、P=0.025和P=0.009)。Logistic回歸分析顯示,TC、MMP-9、IL-33及hs-CRP為CI的獨立危險因素。TC、hs-CRP為TIA的獨立危險因素。MMP-9+IL-33+hs-CRP預測CI發(fā)生的AUC為0.859(95%CI:0.751~0.911),顯著高于MMP-9(AUC為0.711,95%CI:0.649~0.824)、IL-33(AUC為0.698,95%CI:0.659~0.855)和hs-CRP(AUC為0.705,95%CI:0.671~0.848)的診斷效能(Z=9.267、11.553和10.234,均P=0.000)。結論腦梗死、短暫性腦缺血發(fā)作患者存在炎癥因子表達差異,MMP-9、IL-33及hsCRP聯(lián)合檢測對CI具有較高的診斷價值。
[Abstract]:Objective to investigate the expression of different inflammatory factors in patients with cerebral infarction and transient ischemic attack. There were 58 patients with cerebral infarction (CI group) and 50 healthy persons (NC group). Results in CI group, MMP-9(83.14 鹵9.27 渭 g / L NF- 魏 B was 36.88 鹵6.27%. IL-33(71.63 鹵4.83 ng / mL and hs-CRP(12.57 鹵1.29 mg / L respectively. The TIA group was 29.17 鹵4.54 渭 g / L of NF- 魏 B and 31.20 鹵5.97 渭 g / L respectively. IL-33(104.59 鹵8.27 ng / mL and hs-CRP(6.23 鹵1.04 mg / L, the differences between the two groups were statistically significant (P < 0.026). Logistic regression analysis showed that the level of MMP-9 was significantly higher than that in the control group (P < 0. 032, P < 0. 032) and P < 0. 009. Logistic regression. IL-33 and hs-CRP were independent risk factors of CI. TC. Hs-CRP was an independent risk factor for TIA. MMP-9 IL-33 hs-CRP predicted that the AUC of CI was 0.859 (P < 0.05). 95 CI: 0.7511.0.911). Significantly higher than MMP-9(AUC was 0.71195 CI: 0.649% 0.824% IL-33 AUC was 0.698. The diagnostic efficacy of 95 CI: 0.659 / 0.855 and hs-CRP(AUC 0.705 / 95CI: 0.671 / 0.848). Conclusion there is a difference in the expression of inflammatory factors and MMP-9 in patients with cerebral infarction and transient ischemic attack. The combined detection of IL-33 and hsCRP has high diagnostic value for CI.
【作者單位】： 南通市第一人民醫(yī)院神經(jīng)內(nèi)科;
【分類號】：R743.3
【正文快照】： 短暫性腦缺血發(fā)作(transient ischemic attack,TIA)主要指腦或者視覺功能急性喪失,癥狀持續(xù)1h,而在2 4 h內(nèi)恢復,以往的研究認為該病為一種良性疾病,并未得到人們的重視[1],研究顯示TIA有發(fā)展為CI的風險[2]。臨床上已經(jīng)證實了炎癥因子參與了腦血管病的發(fā)展過程,但是不同炎癥因，

本文編號：1472298