本文關(guān)鍵詞： 依從性 阿司匹林抵抗 腦梗死　出處：《中風(fēng)與神經(jīng)疾病雜志》2017年12期 　論文類(lèi)型：期刊論文

【摘要】：目的觀察患者依從性與阿司匹林抵抗的關(guān)系,并探討影響患者依從性的相關(guān)因素。方法納入2014年-2015年于青島大學(xué)附屬醫(yī)院出院的首發(fā)腦梗死患者451例,且住院時(shí)血栓彈力圖(TEG)結(jié)果顯示AA抑制率≥50%,隨訪12個(gè)月,終點(diǎn)事件為腦梗死復(fù)發(fā)或者死亡,復(fù)測(cè)患者AA抑制率結(jié)果,并運(yùn)用Morisky-8服藥依從性量表對(duì)患者進(jìn)行服藥依從性評(píng)估。結(jié)果共有429例患者納入分析,AR患者為52例占12.12%,依從性差是AR發(fā)生的獨(dú)立危險(xiǎn)因素(P=0.027,OR=3.147,95%CI 1.004~9.834)。依從性較好比例只有35.89%,文化程度低、月收入低、醫(yī)療費(fèi)用支付方式-自費(fèi)、疾病了解少是依從性差的危險(xiǎn)因素(P0.05)。結(jié)論依從性差是阿司匹林抵抗發(fā)生的獨(dú)立危險(xiǎn)因素;文化程度低、月收入低、醫(yī)療費(fèi)用支付方式-自費(fèi)、疾病了解少是依從性差的危險(xiǎn)因素。
[Abstract]:Objective to observe the relationship between patient compliance and aspirin resistance. Methods 451 patients with initial cerebral infarction who were discharged from the affiliated Hospital of Qingdao University from 2014 to 2015 were included. The results of thromboelastography showed that the inhibition rate of AA was more than 50. After 12 months follow-up, the end point event was recurrence or death of cerebral infarction, and the inhibition rate of AA was measured again. The Morisky-8 compliance scale was used to evaluate the drug compliance of the patients. Results A total of #number1# patients were included in the analysis of 52 patients with AR, accounting for 12.12%. Poor compliance was the independent risk factor of AR. The ratio of compliance was only 35.89%. Low education level, low monthly income, medical expense payment method, low understanding of disease are the risk factors of poor compliance (P 0.05). Conclusion poor compliance is an independent risk factor for aspirin resistance. Low level of education, low monthly income, way of paying for medical expenses-self-expense and little understanding of disease are the risk factors of poor compliance.
【作者單位】： 青島大學(xué)附屬醫(yī)院神經(jīng)內(nèi)科;吉林大學(xué)第二醫(yī)院心血管內(nèi)科;
【基金】：青島市民生科技計(jì)劃項(xiàng)目(15-9-2-92-nsh)
【分類(lèi)號(hào)】：R743.3
【正文快照】： 缺血性腦卒中具有較高的致殘率和致死率,其二級(jí)預(yù)防越來(lái)越得到重視。阿司匹林作為腦梗死二級(jí)預(yù)防指南推薦藥,應(yīng)用越來(lái)越廣泛[1]。部分患者即使常規(guī)服用阿司匹林仍繼續(xù)經(jīng)受缺血性心腦血管事件,稱(chēng)為阿司匹林抵抗(AR)[2]。研究顯示AR在腦梗死的發(fā)生及復(fù)發(fā)中起重要作用[3]。AR發(fā)生

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