本文關(guān)鍵詞： 癲癇大發(fā)作 定癇丸 丙戊酸鈉 臨床研究　出處：《南京中醫(yī)藥大學(xué)》2014年碩士論文　論文類(lèi)型：學(xué)位論文

【摘要】：目的：觀(guān)察研究定癇丸聯(lián)合丙戊酸鈉片治療癲癇大發(fā)作的臨床效果,從而為癲癇患者選擇中西醫(yī)綜合治療提供可靠的臨床依據(jù)。方法：使用隨機(jī)平行對(duì)照方法,選取2012年9月至2013年8月期間在蘇州市吳江區(qū)中醫(yī)醫(yī)院治療的癲癇患者一共64名,分為對(duì)照組(30名)：?jiǎn)斡每诜焖徕c片治療癲癇(0.2g/次,3次/d),口服；實(shí)驗(yàn)組(34名)：在對(duì)照組的基礎(chǔ)上加用定癇丸(4g/次,早晚口服),連續(xù)治療12個(gè)月,每半年為一個(gè)療程,每個(gè)療程結(jié)束后統(tǒng)計(jì)兩組患者在治療期間癲癇的發(fā)作次數(shù)、癲癇發(fā)作的持續(xù)時(shí)間、癲癇發(fā)作的嚴(yán)重程度積分,整個(gè)實(shí)驗(yàn)結(jié)束后統(tǒng)計(jì)不良反應(yīng)的發(fā)生,所有患者均由同一位醫(yī)師進(jìn)行統(tǒng)計(jì)和評(píng)價(jià),實(shí)驗(yàn)數(shù)據(jù)采用SPSS19.0軟件進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果：(1)在癲癇的發(fā)作頻率、持續(xù)時(shí)間和癥狀積分上面,治療組在第一療程和第二療程上均優(yōu)于對(duì)照組(P0.05),差異有統(tǒng)計(jì)學(xué)意義；(2)在不良反應(yīng)的發(fā)生上兩組數(shù)據(jù)差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論：定癇丸聯(lián)合丙戊酸鈉治療癲癇大發(fā)作的效果明顯優(yōu)于單用丙戊酸鈉,且并不增加不良反應(yīng)的發(fā)生,值得臨床推廣運(yùn)用。
[Abstract]:Objective: to observe and study the clinical effect of Dingxian pills combined with sodium valproate in the treatment of epilepsy, so as to provide reliable clinical basis for the patients with epilepsy to choose comprehensive treatment of traditional Chinese and western medicine. Methods: a randomized parallel control method was used. A total of 64 epileptic patients were selected from September 2012 to August 2013 who were treated in traditional Chinese Medicine Hospital of Wu Jiang District of Suzhou City. The patients were divided into control group (n = 30): oral sodium valproate tablet was used only to treat epilepsy with 0.2 g / 3 / d. Experimental group (n = 34): on the basis of the control group, Dingxian pills were given 4g / time, orally orally in the morning and evening, for 12 months continuously, every six months as a course of treatment. At the end of each course, the number of seizures, the duration of seizures, the severity of epileptic seizures, and the occurrence of adverse reactions after the treatment of the two groups were counted. All the patients were statistically evaluated by the same physician. The experimental data were statistically analyzed by SPSS19.0 software. Results: 1) the seizure frequency, duration and symptom score of epilepsy. The treatment group was better than the control group in the first course and the second course of treatment, the difference was statistically significant. There was no significant difference between the two groups in the occurrence of adverse reactions (P 0.05). Conclusion: the effect of Dingxian pills combined with valproate sodium in the treatment of epileptic seizures is significantly better than that of sodium valproate alone. And does not increase the occurrence of adverse reactions, worthy of clinical application.
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類(lèi)號(hào)】：R742.1

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