本文關(guān)鍵詞： 血脂異常 非高密度脂蛋白膽固醇 急性缺血性卒中 神經(jīng)功能損害　出處：《中國(guó)動(dòng)脈硬化雜志》2017年09期 　論文類(lèi)型：期刊論文

【摘要】：目的探討血清非高密度脂蛋白膽固醇(non-HDLC)對(duì)缺血性腦卒中急性期神經(jīng)功能損害的影響及其在風(fēng)險(xiǎn)評(píng)估中的臨床價(jià)值。方法選擇符合入組條件的急性缺血性卒中患者共611例,應(yīng)用美國(guó)國(guó)立衛(wèi)生研究院卒中量表(NIHSS)、中國(guó)腦卒中患者臨床神經(jīng)功能缺損程度評(píng)分量表(1995)(CSS)、歐洲版神經(jīng)功能缺損評(píng)分(ESS)以及日常生活能力評(píng)定量表Barthel指數(shù)(BI)評(píng)價(jià)神經(jīng)功能。同時(shí)測(cè)定空腹血糖、糖化血紅蛋白(HbA1c)、血清高敏C反應(yīng)蛋白(hs-CRP)、同型半胱氨酸(Hcy)、總膽固醇(TC)、甘油三酯(TG)、高密度脂蛋白膽固醇(HDLC)和低密度脂蛋白膽固醇(LDLC)等生化指標(biāo),并計(jì)算出non-HDLC的含量,比較non-HDLC高水平組與理想水平組患者NIHSS、CSS、ESS、BI分值,以探討高non-HDLC水平與急性缺血性卒中神經(jīng)功能損害的關(guān)系。結(jié)果與non-HDLC理想水平組患者相比,高non-HDLC水平組患者體質(zhì)指數(shù)高、NIHSS、CSS評(píng)分高(P0.05),ESS和BI分值低(P0.05)。血清TC、TG、LDLC、Hcy、空腹血糖和HbA1c水平高,HDLC水平低(P0.05)。相關(guān)分析發(fā)現(xiàn),隨著non-HDLC水平升高,急性缺血性卒中神經(jīng)功能損害的危險(xiǎn)性明顯增加。結(jié)論 Non-HDLC水平增高是缺血性腦卒中患者急性期神經(jīng)功能損害的危險(xiǎn)因素,可作為缺血性腦卒中神經(jīng)功能損害危險(xiǎn)評(píng)估的有效靶點(diǎn)。
[Abstract]:Objective to study the serum non-HDLC of non-high density lipoprotein cholesterol. Methods 611 patients with acute ischemic stroke were selected. The National Institutes of Health Stroke scale (NIHSS) was used to evaluate the clinical neurological impairment of stroke patients in China. Nerve function was evaluated by European version of neurologic impairment scale (ESS) and activity of Daily living (ADL) rating scale (Barthel). Fasting blood glucose was measured at the same time. Glycosylated hemoglobin (HbA1cU), serum Gao Min C-reactive protein (hs-CRPN), homocysteine (Hcyl), total cholesterol (TCX), triglyceride (TG). High density lipoprotein cholesterol (HDLC) and low density lipoprotein cholesterol (LDL-C) were used to calculate the content of non-HDLC. To compare the scores of non-HDLC in high level group and ideal group. To investigate the relationship between high non-HDLC level and neurological impairment in patients with acute ischemic stroke. Patients with high non-HDLC level had high BMI and high non-HDLC scores (P 0.05) and low BI scores (P 0.05). Hcy, fasting blood glucose and HbA1c level were high and low (P 0.05). Correlation analysis showed that with the increase of non-HDLC level. Conclusion the increased level of Non-HDLC is a risk factor for acute neurological impairment in patients with acute ischemic stroke. It can be used as an effective target for risk assessment of neurological impairment in ischemic stroke.
【作者單位】： 天津醫(yī)科大學(xué)研究生院;天津市環(huán)湖醫(yī)院中醫(yī)科;天津市環(huán)湖醫(yī)院神經(jīng)內(nèi)科三病區(qū);
【基金】：天津市科技計(jì)劃項(xiàng)目(13ZCZDSY0 1600) 天津市衛(wèi)生局科技重點(diǎn)項(xiàng)目(13K G121)
【分類(lèi)號(hào)】：R743.3
【正文快照】： 3.天津市環(huán)湖醫(yī)院神經(jīng)內(nèi)科三病區(qū),天津市300350)中國(guó)缺血性卒中發(fā)病率遠(yuǎn)遠(yuǎn)高于西方國(guó)家,并且呈現(xiàn)高死亡率、高復(fù)發(fā)率、高致殘率特點(diǎn)。其急性期易造成諸多神經(jīng)功能損害,如意識(shí)不清、凝視、視野缺損、面癱、肢體運(yùn)動(dòng)損傷、共濟(jì)功能受損、感覺(jué)減退、語(yǔ)言功能減退等。血脂異常是缺

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